Prefrontal activation during a working memory task differs between patients with unipolar and bipolar depression: A preliminary exploratory study

Journal of Affective Disorders, Journal Year: 2017, Volume and Issue: 225, P. 64 - 70

Published: July 19, 2017

Language: Английский

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Effects of HD‐tDCS on Resting‐State Functional Connectivity in the Prefrontal Cortex: An fNIRS Study

Complexity, Journal Year: 2018, Volume and Issue: 2018(1)

Published: Jan. 1, 2018

Functional connectivity is linked to several degenerative brain diseases prevalent in our aging society. Electrical stimulation used for the clinical treatment and rehabilitation of patients with many cognitive disorders. In this study, effects high‐definition transcranial direct current (HD‐tDCS) on resting‐state networks human prefrontal cortex were investigated by using functional near‐infrared spectroscopy (fNIRS). The intrahemispheric as well interhemispheric changes induced 1 mA HD‐tDCS examined 15 healthy subjects. Pearson correlation coefficient‐based matrices generated from filtered time series oxyhemoglobin (ΔHbO) signals converted into binary matrices. Common graph theory metrics computed evaluate network changes. Systematic interhemispheric, intrahemispheric, intraregional analyses demonstrated that positively affected cortex. poststimulation was increased throughout region, while focal an rate stimulated hemisphere. clearly distinguished prestimulation a range thresholds. results study suggest can be increase explored clinically neurorehabilitation diseases.

Language: Английский

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Promising Neuroimaging Biomarkers in Depression

Psychiatry Investigation, Journal Year: 2019, Volume and Issue: 16(9), P. 662 - 670

Published: Sept. 23, 2019

The neuroimaging has been applied in the study of pathophysiology major depressive disorder (MDD). In this review article, several kinds methodologies would be discussed to summarize promising biomarkers MDD. For magnetic resonance imaging (MRI) and magnetoencephalography field, literature showed potentially roles frontal lobes, such as anterior cingulate cortex (ACC), dorsolateral prefrontal (DLPFC) orbitofrontal (OFC). addition, limbic regions, hippocampus amygdala, might for structures functions ACC, DLPFC, OFC, amygdala confirmed prediction antidepressant treatment responses cognitive control emotion regulation these regions crucial establishment biomarkers. near-infrared spectroscopy studies demonstrated that blood flow lobe, DLPFC field spectroscopy. electroencephalography also supported role OFC biomarker exploration, especially sleep electroencephalogram detect positron emission tomography (PET) single-photon computed (SPECT) MDD amygdala. However, additional findings brainstem midbrain were found PET SPECT. seemed focused fronto-limbic regions.

Language: Английский

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Classifying Major Depressive Disorder Using fNIRS During Motor Rehabilitation

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2020, Volume and Issue: 28(4), P. 961 - 969

Published: Feb. 7, 2020

Major depressive disorder (MDD) has shown to negatively impact physical recovery in a variety of medical events (e.g., stroke and spinal cord injuries). Yet depression assessments, which are typically subjective nature, seldom considered develop or guide rehabilitation strategies. The present study developed predictive assessment technique using functional near-infrared spectroscopy (fNIRS) that can be rapidly integrated performed concurrently with existing tasks. Thirty-one volunteers, including 14 adults clinically diagnosed MDD 17 healthy adults, participated the study. Brain oxy-hemodynamic (HbO) responses were recorded 16-channel wearable continuous-wave fNIRS device while volunteers Grasp Release Test four 16-minute blocks. Ten features, extracted from HbO signals, each channel served as inputs XGBoost Random Forest algorithms for block combination successive Top 5 common features resulted classification accuracy 92.6%, sensitivity 84.8%, specificity 91.7% classifier. This identified mean HbO, full width half maximum kurtosis, specific neuromarkers, predicting across depression-related regions interests (i.e., dorsolateral ventrolateral prefrontal cortex). Our results suggest head probe monitoring brain regions, limiting extraction few enable quick setup rapid patients. overarching goal is embed neurotechnology during post-stroke post-spinal-cord-injury sessions monitor patients' symptomology so actively decisions about motor therapies.

Language: Английский

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fNIRS Evidence for Distinguishing Patients With Major Depression and Healthy Controls

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2021, Volume and Issue: 29, P. 2211 - 2221

Published: Jan. 1, 2021

In recent years, major depressive disorder (MDD) has been shown to negatively impact physical recovery in a variety of patients. Functional near-infrared spectroscopy (fNIRS) is tool that can potentially supplement clinical interviews and mental state examinations establish psychiatric diagnosis monitor treatment progress. Thirty-two subjects, including 16 patients clinically diagnosed with MDD healthy controls (HCs), participated the study. Brain oxyhemoglobin (HbO) deoxyhemoglobin (HbR) responses were recorded using 22-channel continuous-wave fNIRS device while subjects performed emotional sound test. This study evaluated difference between HCs methods. comparison Pearson correlation coefficients HbO/HbR each channel four scores, had significantly different Athens Insomnia Scale (AIS) scores. By quantitative evaluation functional association, we found aberrant connectivity compared HCs. Furthermore, concluded HCs, there marked abnormalities blood oxygen bilateral ventrolateral prefrontal cortex (VLPFC) dorsolateral (DLPFC). Four statistical-based features extracted from HbO signals vector-based both HbR served as inputs simple neural networks (multilayer network (MNN), feedforward (FNN), cascade forward (CFNN) recurrent (RNN)). Through an analysis combinations features, combination 4 common (mean, STD, area under receiver operating characteristic curve (AUC) slope) yielded highest classification accuracy 89.74% for fear emotion. The novel feature (CBV, COE, |L | K) resulted 99.94% top 10 selected by ReliefF selection algorithm, resulting accuracies 83.52% 91.99%, respectively. identified AUC angle K specific neuromarkers predicting across depression-related regions (PFC). These findings suggest measurement PFC may serve supplementary test routine practice further support MDD.

Language: Английский

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Cross-subject classification of depression by using multiparadigm EEG feature fusion

Computer Methods and Programs in Biomedicine, Journal Year: 2023, Volume and Issue: 233, P. 107360 - 107360

Published: Jan. 18, 2023

Language: Английский

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Use of the Modified Emotional Stroop Task to Detect Suicidality in College Population

Suicide and Life-Threatening Behavior, Journal Year: 2015, Volume and Issue: 46(1), P. 55 - 66

Published: June 29, 2015

This cross-sectional study investigated the usefulness of emotional Stroop task (EST) as a behavioral marker for suicidal behaviors in college population. Eight hundred twenty students were asked to perform on EST and respond suicide-related self-report measures. The results indicated that past suicide attempters slower responding word "suicide" compared nonattempters, female showed more delayed response when their most recent attempt was made 12 months. We did not find evidence could outperform traditional

Language: Английский

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Dorsolateral prefrontal hemodynamic responses during a verbal fluency task in hypomanic bipolar disorder

Bipolar Disorders, Journal Year: 2014, Volume and Issue: 17(2), P. 172 - 183

Published: Sept. 4, 2014

Objectives Neuroimaging studies have suggested prefrontal dysfunction in response to cognitive activation bipolar disorder ( BD ). However, its characteristics manic states not been well understood. Thus, we compared hemodynamic responses during a task between hypomanic and depressive . We then longitudinally subsequent euthymic states. Methods The function of 27 patients with (11 16 depressed) 12 age‐ gender‐matched healthy controls HC s) was evaluated using near‐infrared spectroscopy NIRS ) verbal fluency VFT Hypomanic symptoms were assessed the Young Mania Rating Scale. Among 11 patients, eight participated second measurement after their resolved. Results performance did differ among hypomanic, depressed, groups. Both groups exhibited significantly lower than s broader bilateral cortex. Hemodynamic changes left dorsolateral cortex DLPFC larger those depressed patients. In addition, symptom severity positively correlated frontopolar Follow‐up revealed that decreased Conclusions Combining cross‐sectional longitudinal assessments, present results suggest associated could be useful tool for objectively evaluating state‐dependent hemodynamics

Language: Английский

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Association between longitudinal changes in prefrontal hemodynamic responses and social adaptation in patients with bipolar disorder and major depressive disorder

Journal of Affective Disorders, Journal Year: 2015, Volume and Issue: 176, P. 78 - 86

Published: Jan. 22, 2015

Language: Английский

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Characterizing emotional Stroop interference in posttraumatic stress disorder, major depression and anxiety disorders: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2019, Volume and Issue: 14(4), P. e0214998 - e0214998

Published: April 9, 2019

Background Posttraumatic stress disorder is a debilitating psychiatric characterized by symptoms of intrusive re-experiencing trauma, avoidance and hyper-arousal. Diagnosis treatment PTSD further complicated concurrently occurring disorders, the most frequent being major depressive anxiety disorders. Previous research highlights that attentional processing in posttraumatic associated with substantial interference emotional stimuli, phenomenon also observed these However, diagnosis-relevance this remains elusive. Here, we investigated Stroop for diagnosis-related generally negative positive stimuli disorder, Methods We performed systematic database search PubMed (Medline), Cochrane Library PsycINFO on performance individuals diagnosis or disorders separately. Mean effect sizes, standard errors confidence intervals were estimated each clinical group healthy control comparison using random models. Results As compared to group, displayed greater but not stimuli. The groups showed age sex had no significant impact interference. Conclusions These findings highlight importance diagnosis-relevant information all three populations, Further, indicate impaired bias mood-congruent general Finally, it be studied whether influence are perceived as related.

Language: Английский

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