Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation

Information Fusion, Journal Year: 2020, Volume and Issue: 64, P. 149 - 187

Published: July 17, 2020

Language: Английский

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How Inflammation Affects the Brain in Depression: A Review of Functional and Structural MRI Studies

Journal of Clinical Neurology, Journal Year: 2021, Volume and Issue: 17(4), P. 503 - 503

Published: Jan. 1, 2021

This narrative review discusses how peripheral and central inflammation processes affect brain function structure in depression, reports on recent inflammatory marker-based functional structural magnetic resonance imaging (MRI) studies from the perspective of neural-circuit dysfunction depression. Chronic stress stimulates activity microglial cells, which increases production pro-inflammatory cytokines brain. In addition, activation promotes a shift synthesis serotonin to neurotoxic metabolites kynurenine pathway, induces glutamate-mediated excitotoxicity neurons. Furthermore, region specificity is hypothesized contribute vulnerability specific regions depression-related neural circuits inflammation-mediated injury. MRI are increasingly investigating blood levels markers such as C-reactive protein, interleukin (IL)-1β, IL-6, tumor necrosis factor-α associated with neuroimaging Functional have found that aberrant patterns altered connectivity involved emotion regulation, reward processing, cognitive control Structural suggested related reduced cortical gray matter subcortical volumes, thinning, decreased integrity white tracts within circuits. These findings may improve our understanding relationships between neuroinflammatory at molecular level macroscale vivo neuralcircuit

Language: Английский

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Inflammatory Process and Immune System in Major Depressive Disorder

The International Journal of Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 25(1), P. 46 - 53

Published: Oct. 29, 2021

Abstract Major depressive disorder (MDD) is one of the most common psychiatric illnesses in general population. In mental disorders, activation inflammatory pathways brain a major producer excitotoxicity and an inducer oxidative stress. The occurrence these 2 events partly responsible for neuronal damage inherent patients with disorders. case MDD, release hormone increase pro-inflammatory cytokines plasma indicators stress have been identified as consequences this event. important affectations MDD are changes their cognitive executive functions due to inflammation. Hence, biomarkers can serve diagnostic severity classification tools treatment. work, we described communication pathway between immune neuroendocrine systems suggested possible therapeutic options disease.

Language: Английский

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Neural substrates for late-life depression: A selective review of structural neuroimaging studies

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2020, Volume and Issue: 104, P. 110010 - 110010

Published: June 13, 2020

Language: Английский

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fNIRS Evidence for Distinguishing Patients With Major Depression and Healthy Controls

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2021, Volume and Issue: 29, P. 2211 - 2221

Published: Jan. 1, 2021

In recent years, major depressive disorder (MDD) has been shown to negatively impact physical recovery in a variety of patients. Functional near-infrared spectroscopy (fNIRS) is tool that can potentially supplement clinical interviews and mental state examinations establish psychiatric diagnosis monitor treatment progress. Thirty-two subjects, including 16 patients clinically diagnosed with MDD healthy controls (HCs), participated the study. Brain oxyhemoglobin (HbO) deoxyhemoglobin (HbR) responses were recorded using 22-channel continuous-wave fNIRS device while subjects performed emotional sound test. This study evaluated difference between HCs methods. comparison Pearson correlation coefficients HbO/HbR each channel four scores, had significantly different Athens Insomnia Scale (AIS) scores. By quantitative evaluation functional association, we found aberrant connectivity compared HCs. Furthermore, concluded HCs, there marked abnormalities blood oxygen bilateral ventrolateral prefrontal cortex (VLPFC) dorsolateral (DLPFC). Four statistical-based features extracted from HbO signals vector-based both HbR served as inputs simple neural networks (multilayer network (MNN), feedforward (FNN), cascade forward (CFNN) recurrent (RNN)). Through an analysis combinations features, combination 4 common (mean, STD, area under receiver operating characteristic curve (AUC) slope) yielded highest classification accuracy 89.74% for fear emotion. The novel feature (CBV, COE, |L | K) resulted 99.94% top 10 selected by ReliefF selection algorithm, resulting accuracies 83.52% 91.99%, respectively. identified AUC angle K specific neuromarkers predicting across depression-related regions (PFC). These findings suggest measurement PFC may serve supplementary test routine practice further support MDD.

Language: Английский

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Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(1), P. 500 - 542

Published: May 5, 2021

Abstract Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population‐based samples have identified normative differences between males females, many which are exacerbated psychiatric neurological conditions. Still, sex MRI outcomes understudied, particularly clinical with known disease risk, prevalence, expression symptoms. Here we review the existing literature on adult 14 distinct disorders. We discuss commonalities sources variance study designs, analysis procedures, subtype effects, impact these factors interpretation. Lastly, identify key problems neuroimaging offer potential recommendations address current barriers optimize rigor reproducibility. In particular, emphasize importance large‐scale initiatives such as Enhancing NeuroImaging Genetics through Meta‐Analyses consortium, UK Biobank, Human Connectome Project, others provide unprecedented power evaluate sex‐specific phenotypes major diseases.

Language: Английский

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Fronto-limbic neuroimaging biomarkers for diagnosis and prediction of treatment responses in major depressive disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2020, Volume and Issue: 107, P. 110234 - 110234

Published: Dec. 25, 2020

Language: Английский

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Reviving: restoring depression-like behaviour through glial cell–derived neurotrophic factor treatment in the medial prefrontal cortex

Journal of Psychiatry and Neuroscience, Journal Year: 2024, Volume and Issue: 49(1), P. E23 - E34

Published: Feb. 1, 2024

Background:

Depression is a prevalent nonmotor symptom in Parkinson disease and can greatly reduce the quality of life for patients; dopamine receptors found glutamatergic pyramidal cells medial prefrontal cortex (mPFC) play role regulating local field activity, which turn affects behavioural mood disorders. Given research showing that glial cell–derived neurotrophic factor (GDNF) may have an antidepressant effect, we sought to evaluate impact exogenous GDNF on depression-like behaviour mouse models disease.

Methods:

We used established subacute model mice involving intraperitoneal injection 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), followed by brain stereotaxic into mPFC region. Subsequently, assessed using sucrose preference test, forced swimming test tail suspension while also evaluating protein expression mPFC.

Results:

included 60 mice, divided 3 groups, including control group (saline injection), MPTP plus saline group. led increase receptor D1 (DRD1) levels. observed activating kinase A pathway through DRD1 produced prolonged response. Under stimulation, D2 (DRD2) remained constant, suggesting DRD2 signal was ineffective alleviating symptoms. Moreover, our investigation involved Golgi staining Western blot techniques, enhanced synaptic plasticity, increased dendritic branches, spines retrograde protection after treatment models.

Limitations:

subtle motor phenotype became evident only toward conclusion testing period. The study exclusively male no separate receiving experimental design.

Conclusion:

Our findings support positive effect mediated signalling mPFC, could facilitate depression remission

Language: Английский

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The effectiveness of vortioxetine on neurobiochemical metabolites and cognitive of major depressive disorders patients: A 8-week follow-up study

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 799 - 807

Published: Feb. 3, 2024

Language: Английский

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The regional homogeneity of cingulate-precuneus regions: The putative biomarker for depression and anxiety

Journal of Affective Disorders, Journal Year: 2018, Volume and Issue: 229, P. 171 - 176

Published: Jan. 3, 2018

Language: Английский

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