Evaluation of the spatial variability in the major resting‐state networks across human brain functional atlases DOI Creative Commons
Gaëlle E. Doucet, Won Hee Lee, Sophia Frangou

et al.

Human Brain Mapping, Journal Year: 2019, Volume and Issue: 40(15), P. 4577 - 4587

Published: July 19, 2019

The human brain is intrinsically organized into resting-state networks (RSNs). Currently, several functional atlases are used to define the spatial constituents of these RSNs. However, there significant concerns about interatlas variability. In response, we undertook a quantitative comparison five major RSNs (default mode [DMN], salience, central executive, sensorimotor, and visual networks) across currently available (n = 6) in which demonstrated that (a) similarity between was modest positively linked size sample construct them; (b) atlases, overlap among ranged 17 76% (mean 39%), resulted variability their connectivity; (c) lower order were generally spatially conserved atlases; (d) higher RSNs, DMN most (e) voxel-wise flexibility (i.e., likelihood voxel change network assignment atlases) high for subcortical regions low sensory, motor medial prefrontal cortices, precuneus. facilitate RSN reproducibility future studies, provide new freely Consensual Atlas REsting-state Networks, based on reliable atlases.

Language: Английский

Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks DOI
Lucina Q. Uddin, B.T. Thomas Yeo, R. Nathan Spreng

et al.

Brain Topography, Journal Year: 2019, Volume and Issue: 32(6), P. 926 - 942

Published: Nov. 1, 2019

Language: Английский

Citations

588
Functional boundaries in the human cerebellum revealed by a multi-domain task battery DOI
Maedbh King, Carlos R. Hernandez‐Castillo, Russell A. Poldrack

et al.

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(8), P. 1371 - 1378

Published: July 8, 2019

Language: Английский

Citations

561
Topographic organization of the human subcortex unveiled with functional connectivity gradients DOI
Ye Tian, Daniel S. Margulies, Michael Breakspear

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(11), P. 1421 - 1432

Published: Sept. 28, 2020

Language: Английский

Citations

541
A Domain-General Cognitive Core Defined in Multimodally Parcellated Human Cortex DOI Creative Commons
Moataz Assem,

Matthew F. Glasser,

David C. Van Essen

et al.

Cerebral Cortex, Journal Year: 2020, Volume and Issue: 30(8), P. 4361 - 4380

Published: Jan. 22, 2020

Numerous brain imaging studies identified a domain-general or "multiple-demand" (MD) activation pattern accompanying many tasks and may play core role in cognitive control. Though this finding is well established, the limited spatial localization provided by traditional methods precluded consensus regarding precise anatomy, functional differentiation, connectivity of MD system. To address these limitations, we used data from 449 subjects Human Connectome Project, with cortex each individual parcellated using neurobiologically grounded multimodal MRI features. The conjunction three contrasts reveals 10 widely distributed parcels per hemisphere that are most strongly activated functionally interconnected, surrounded penumbra 17 additional areas. Outside cerebral cortex, prominent caudate cerebellum. Comparison canonical resting-state networks shows regions concentrated fronto-parietal network but also engaging other networks. activations show modest relative task preferences strong co-recruitment. With anatomical organization, mosaic preferences, interconnectivity, suggest positioned to integrate assemble diverse components operations. Our delineation provides basis for refined analyses their functions.

Language: Английский

Citations

290
Universal Transform or Multiple Functionality? Understanding the Contribution of the Human Cerebellum across Task Domains DOI Creative Commons
Jörn Diedrichsen, Maedbh King, Carlos R. Hernandez‐Castillo

et al.

Neuron, Journal Year: 2019, Volume and Issue: 102(5), P. 918 - 928

Published: June 1, 2019

Language: Английский

Citations

244
A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum DOI Creative Commons
Benjamin A. Seitzman, Caterina Gratton, Scott Marek

et al.

NeuroImage, Journal Year: 2019, Volume and Issue: 206, P. 116290 - 116290

Published: Oct. 18, 2019

An important aspect of network-based analysis is robust node definition. This issue critical for functional brain network analyses, as poor choice can lead to spurious findings and misleading inferences about organization. Two sets nodes from our group are well represented in the literature: (1) 264 volumetric regions interest (ROIs) reported Power et al., 2011, (2) 333 cortical surface parcels Gordon 2016. However, subcortical cerebellar structures either incompletely captured or missing these ROI sets. Therefore, properties organization involving subcortex cerebellum may be underappreciated thus far. Here, we apply a winner-take-all partitioning method resting-state fMRI data generate novel functionally-constrained ROIs thalamus, basal ganglia, amygdala, hippocampus, cerebellum. We validate three datasets using several criteria, including agreement with existing literature anatomical atlases. Further, demonstrate that combining established recapitulates extends previously described new set made publicly available general use, full list MNI coordinates labels.

Language: Английский

Citations

207
Task activations produce spurious but systematic inflation of task functional connectivity estimates DOI
Michael W. Cole, Takuya Ito, Douglas H. Schultz

et al.

NeuroImage, Journal Year: 2018, Volume and Issue: 189, P. 1 - 18

Published: Dec. 28, 2018

Language: Английский

Citations

206
Situating the left-lateralized language network in the broader organization of multiple specialized large-scale distributed networks DOI Creative Commons
Rodrigo M. Braga, Lauren M. DiNicola, Hannah Becker

et al.

Journal of Neurophysiology, Journal Year: 2020, Volume and Issue: 124(5), P. 1415 - 1448

Published: Sept. 23, 2020

This research shows that a language network can be identified within individuals using functional connectivity. Organizational details reveal the shares common spatial motif with other association networks, including default and frontoparietal control networks. The is activated by task demands, whereas closely juxtaposed networks are not, suggesting similarly organized but differentially specialized distributed populate cortex.

Language: Английский

Citations

191
Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice DOI Creative Commons
David C. Van Essen, Chad J. Donahue, Timothy S. Coalson

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(52), P. 26173 - 26180

Published: Dec. 23, 2019

Advances in neuroimaging and neuroanatomy have yielded major insights concerning fundamental principles of cortical organization evolution, thus speaking to how well different species serve as models for human brain function health disease. Here, we focus on folding, parcellation, connectivity mice, marmosets, macaques, humans. Cortical folding patterns vary dramatically across species, individual variability increases with surface area. Such issues are best analyzed using surface-based approaches that respect the topology sheet. Many aspects can be revealed 1 type information (modality) at a time, such maps myelin content. However, accurate delineation entire mosaic areas requires multimodal approach about function, architecture, connectivity, topographic organization. Comparisons 4 aforementioned reveal dramatic differences total number arrangement areas, particularly between rodents primates. Hemispheric bilateral asymmetry most pronounced humans, which evaluated high-quality parcellation hundreds individuals. Asymmetries include modest areal size but not identity. Analyses anatomical tracers highly distributed wide range connection weights monkeys mice; indirect measures functional MRI suggest similar pattern Altogether, multifaceted integrated exploring primate nonprimate provides complementary advantages perspectives.

Language: Английский

Citations

189
Default-mode network streams for coupling to language and control systems DOI Open Access
Evan M. Gordon, Timothy O. Laumann, Scott Marek

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(29), P. 17308 - 17319

Published: July 6, 2020

Significance The human brain is organized into large networks. One important network the Default network, which enables cognitive functions such as social thinking, memory, and reward. In group-averaged data, this emerges a unitary whole, despite its involvement in multiple functions. Here, we tested whether networks found individual humans, rather than group-average networks, contain substructure. individuals, consistently nine subnetworks within network. These matched activity patterns during tasks. Some resembled circuits involved specific Others linked to other summary, study describes set of humans.

Language: Английский

Citations

148