Relation of connectome topology to brain volume across 103 mammalian species DOI Creative Commons
Maria Grazia Puxeddu, Joshua Faskowitz, Caio Seguin

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(2), P. e3002489 - e3002489

Published: Feb. 5, 2024

The brain connectome is an embedded network of anatomically interconnected regions, and the study its topological organization in mammals has become paramount importance due to role scaffolding function behavior. Unlike many other observable networks, connections incur material energetic cost, their length density are volumetrically constrained by skull. Thus, open question how differences volume impact topology. We address this issue using MaMI database, a diverse set mammalian connectomes reconstructed from 201 animals, covering 103 species 12 taxonomy orders, whose size varies over more than 4 orders magnitude. Our analyses focus on relationships between modular organization. After having identified modules through multiresolution approach, we observed connectivity features relate structure these relations vary across volume. found that as increases, spatially compact dense, comprising costly connections. Furthermore, investigated spatial embedding shapes communication, finding nodes’ distance progressively impacts communication efficiency. modes variation policies, smaller bigger brains show higher efficiency routing- diffusion-based signaling, respectively. Finally, bridging modularity larger brains, imposes stronger constraints signaling. Altogether, our results systematically related topology tighter restrictions brains.

Language: Английский

Julich-Brain: A 3D probabilistic atlas of the human brain’s cytoarchitecture DOI Open Access
Katrin Amunts, Hartmut Mohlberg, Sebastian Bludau

et al.

Science, Journal Year: 2020, Volume and Issue: 369(6506), P. 988 - 992

Published: Aug. 21, 2020

Cytoarchitecture is a basic principle of microstructural brain parcellation. We introduce Julich-Brain, three-dimensional atlas containing cytoarchitectonic maps cortical areas and subcortical nuclei. The probabilistic, which enables it to account for variations between individual brains. Building such an was highly data- labor-intensive required the development nested, interdependent workflows detecting borders areas, data processing, provenance tracking, flexible execution processing chains handle large amounts at different spatial scales. Full coverage achieved by inclusion gap complement maps. dynamic will be adapted as mapping progresses; openly available support neuroimaging studies well modeling simulation; interoperable, enabling connection other atlases resources.

Language: Английский

Citations

423
Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice DOI Creative Commons
David C. Van Essen, Chad J. Donahue, Timothy S. Coalson

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(52), P. 26173 - 26180

Published: Dec. 23, 2019

Advances in neuroimaging and neuroanatomy have yielded major insights concerning fundamental principles of cortical organization evolution, thus speaking to how well different species serve as models for human brain function health disease. Here, we focus on folding, parcellation, connectivity mice, marmosets, macaques, humans. Cortical folding patterns vary dramatically across species, individual variability increases with surface area. Such issues are best analyzed using surface-based approaches that respect the topology sheet. Many aspects can be revealed 1 type information (modality) at a time, such maps myelin content. However, accurate delineation entire mosaic areas requires multimodal approach about function, architecture, connectivity, topographic organization. Comparisons 4 aforementioned reveal dramatic differences total number arrangement areas, particularly between rodents primates. Hemispheric bilateral asymmetry most pronounced humans, which evaluated high-quality parcellation hundreds individuals. Asymmetries include modest areal size but not identity. Analyses anatomical tracers highly distributed wide range connection weights monkeys mice; indirect measures functional MRI suggest similar pattern Altogether, multifaceted integrated exploring primate nonprimate provides complementary advantages perspectives.

Language: Английский

Citations

189
In vivo direct imaging of neuronal activity at high temporospatial resolution DOI
Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min

et al.

Science, Journal Year: 2022, Volume and Issue: 378(6616), P. 160 - 168

Published: Oct. 13, 2022

There has been a long-standing demand for noninvasive neuroimaging methods that can detect neuronal activity at both high temporal and spatial resolution. We present two-dimensional fast line-scan approach enables direct imaging of with millisecond precision while retaining the resolution magnetic resonance (MRI). This was demonstrated through in vivo mouse brain 9.4 tesla during electrical whisker-pad stimulation. In spike recording optogenetics confirmed correlation observed MRI signal neural activity. It also captured sequential laminar-specific propagation along thalamocortical pathway. high-resolution, will open up new avenues science by providing deeper understanding brain's functional organization, including temporospatial dynamics networks.

Language: Английский

Citations

83
Principles of cortical areas and their implications for neuroimaging DOI Creative Commons
Steven E. Petersen, Benjamin A. Seitzman, Scott M. Nelson

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(17), P. 2837 - 2853

Published: June 3, 2024

Cortical organization should constrain the study of how brain performs behavior and cognition. A fundamental concept in cortical is that arealization: cortex parceled into discrete areas. In part one this report, we review non-human animal studies have illuminated principles arealization by revealing: (1) what defines a area, (2) areas are formed, (3) interact with another, (4) "computations" or "functions" perform. two, discuss these apply to neuroimaging research. doing so, highlight several examples where commonly accepted interpretation observations requires assumptions violate arealization, including nonstationary move on short time scales, large-scale gradients as organizing features, singular functionality perfectly map psychological constructs. Our belief neurobiology strongly guide nature computational explanations.

Language: Английский

Citations

24
Optimization of TMS target engagement: current state and future perspectives DOI Creative Commons
Pantelis Lioumis, Timo Roine, Ida Granö

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 29, 2025

Neuromodulation is based on the principle that brain stimulation produces plastic changes in cerebral circuitry. Given intersubject structural and functional variability, neuromodulation has a personalized effect brain. Moreover, because of dominance interhemispheric differences same individual, characterization specific circuitries involved currently not feasible. This notion extremely important for treatments applied neuropsychiatry. Specifically, efficacy critically dependent anatomical precision target circuitry which been affected by TMS intervention. Furthermore, complete understanding how behaves under stimulation, its neurophysiological response necessary as well. goal can be achieved with TMS–EEG guided current multimodal neuroimaging techniques real time, namely MRI-based segmentation diffusion tractographic analysis.

Language: Английский

Citations

2
A 2020 view of tension-based cortical morphogenesis DOI Creative Commons
David C. Van Essen

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(52), P. 32868 - 32879

Published: Dec. 15, 2020

Mechanical tension along the length of axons, dendrites, and glial processes has been proposed as a major contributor to morphogenesis throughout nervous system [D. C. Van Essen, Nature 385, 313-318 (1997)]. Tension-based (TBM) is conceptually simple general hypothesis based on physical forces that help shape all living things. Moreover, if each axon dendrite strive shorten while preserving connectivity, aggregate wiring would remain low. TBM can explain key aspects how cerebral cerebellar cortices thin, expand in surface area, acquire their distinctive folds. This article reviews progress since 1997 relevant other candidate morphogenetic mechanisms. At cellular level, studies diverse cell types vitro vivo demonstrate plays role many developmental events. tissue I propose differential expansion sandwich plus (DES+) revision original model for cortical folding. It invokes tangential "sulcal zipping" outer margin well white matter core, together competing against radially biased gray matter. Evidence DES+ discussed, experiments are address tenets model. For cortex, multilayer (CMS) account features, including its unique, accordion-like folding adult, specific tenets.

Language: Английский

Citations

107
Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation DOI Creative Commons
Juyoen Hur,

Jason F. Smith,

Kathryn A. DeYoung

et al.

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(41), P. 7949 - 7964

Published: Sept. 21, 2020

When extreme, anxiety—a state of distress and arousal prototypically evoked by uncertain danger—can be debilitating. Uncertain anticipation is a shared feature situations that elicit signs symptoms anxiety across psychiatric disorders, species, assays. Despite the profound significance for human health wellbeing, neurobiology uncertain-threat remains unsettled. Leveraging paradigm adapted from animal research optimized fMRI signal decomposition, we examined neural circuits engaged during temporally certain threat in 99 men women. Results revealed systems recruited are anatomically colocalized frontocortical regions, extended amygdala, periaqueductal gray. Comparison conditions demonstrated this circuitry can fractionated, with regions showing relatively stronger engagement threat, amygdala reverse pattern. Although there widespread agreement bed nucleus stria terminalis dorsal amygdala—the two major subdivisions amygdala—play critical role orchestrating adaptive responses to potential danger, their precise contributions have remained contentious. Follow-up analyses these show statistically indistinguishable anticipation. These observations provide framework conceptualizing fear, understanding functional neuroanatomy humans, accelerating development more effective intervention strategies pathological anxiety. SIGNIFICANCE STATEMENT Anxiety—an emotion associated harm—has public health, yet underlying unclear. novel neuroimaging large sample, identify core circuit responsive both anticipation, fractionated into bias one kind or other. The occupies center stage neuropsychiatric models anxiety, but its architecture has Here demonstrate threat. Collectively, indicate need revise how think about fear.

Language: Английский

Citations

99
Divergence of rodent and primate medial frontal cortex functional connectivity DOI Open Access
David J. Schaeffer, Yuki Hori, Kyle M. Gilbert

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(35), P. 21681 - 21689

Published: Aug. 17, 2020

Significance The question of the whether rodent and primate medial frontal cortex (MFC) share similar functional organization, is functionally analogous to lateral prefrontal (LPFC) a contentious issue. Here, we probe this long-standing by comparing whole-brain connectivity MFC in rodents, nonhuman primates (marmosets), humans. results demonstrated remarkably intrinsic organization across three species, but clear differences between connectivity. Furthermore, contrast common proposal that rat with LFC, our demonstrate LFC interareal

Language: Английский

Citations

96
Principles of Corticocortical Communication: Proposed Schemes and Design Considerations DOI
Adam Kohn,

Anna I. Jasper,

João D. Semedo

et al.

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(9), P. 725 - 737

Published: Aug. 5, 2020

Language: Английский

Citations

91
Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing DOI Creative Commons
Joonas A. Autio,

Matthew F. Glasser,

Takayuki Ose

et al.

NeuroImage, Journal Year: 2020, Volume and Issue: 215, P. 116800 - 116800

Published: April 8, 2020

Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization primates including humans. However, tools and methods for noninvasive image acquisition (e.g. MRI RF coils pulse sequence protocols) data preprocessing have lagged behind those developed To resolve structural functional characteristics smaller macaque brain, high spatial, temporal, angular resolutions combined with signal-to-noise ratio required ensure good quality. address these challenges, we 24-channel receive coil 3-T parallel imaging capabilities. This enables adaptation Human Connectome Project (HCP) protocols in-vivo brain. In addition, adapted HCP spatial minimal structural, (fMRI), diffusion (dMRI). The provides necessary efficiency in acquisition, allowing four- five-fold accelerations dMRI fMRI. Automated FreeSurfer segmentation cortex, reconstruction surface, removal artefacts nuisance signals fMRI, distortion correction all performed well, overall quality basic neurobiological measures was comparable HCP. Analyses connectivity fMRI revealed sensitivity as compared from publicly shared datasets. Tractography-based estimates correlated tracer similarly that achieved using ex-vivo dMRI. resulting HCP-style vivo show considerable promise analyzing architecture advanced previously only been available studies human

Language: Английский

Citations

90