Rational inattention and tonic dopamine DOI Creative Commons
John G. Mikhael, Lucy Lai, Samuel J. Gershman

et al.

PLoS Computational Biology, Journal Year: 2021, Volume and Issue: 17(3), P. e1008659 - e1008659

Published: March 24, 2021

Slow-timescale (tonic) changes in dopamine (DA) contribute to a wide variety of processes reinforcement learning, interval timing, and other domains. Furthermore, tonic DA exert distinct effects depending on when they occur (e.g., during learning vs. performance) what task the subject is performing operant classical conditioning). Two influential theories DA—the average reward theory Bayesian which controls precision—have each been successful at explaining subset empirical findings. But how same signal performs two seemingly functions without creating crosstalk not well understood. Here we reconcile under unifying framework ‘rational inattention,’ (1) conceptually links precision, (2) outlines manipulations affect this relationship, so doing, (3) captures new phenomena. In brief, rational inattention asserts that agents can increase their precision (and thus improve by paying cognitive cost. Crucially, whether cost worth depends availability, reported DA. The monotonic relationship between means contains information necessary retrieve precision. When needed after performed, as presumed inference, acute will bias behavior predictable ways. We show reconciles remarkably large collection experimental predicts from positive negative feedback should be enhanced high low states, respectively, tip exploration-exploitation balance toward exploitation. speed internal clock decrease extent interference temporal stimuli reproduction (the central tendency effect). Finally, makes predictions these critically dependent controllability rewards, post-reward delays intertemporal choice tasks underestimated, clock—thus capturing findings are unexplained either alone. Our results suggest common computational repertoire may underlie heterogeneous roles

Language: Английский

Current Understanding of Hydrogel for Drug Release and Tissue Engineering DOI Creative Commons
Lanjie Lei, Yujing Bai,

Xinyun Qin

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(5), P. 301 - 301

Published: May 15, 2022

Due to their good absorption, satisfactory biocompatibility, and high safety, hydrogels have been widely used in the field of biomedicine, including for drug delivery tissue regeneration. In this review, we introduce characteristics crosslinking methods natural synthetic hydrogels. Then, highlight design principle intelligent (i.e., responsive hydrogels) release. Moreover, application release engineering, limitations research directions hydrogel engineering are also considered. We hope that review can provide a reference follow-up studies related fields.

Language: Английский

Citations

98
What do reinforcement learning models measure? Interpreting model parameters in cognition and neuroscience DOI Creative Commons
Maria K. Eckstein, Linda Wilbrecht, Anne Collins

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2021, Volume and Issue: 41, P. 128 - 137

Published: July 3, 2021

Language: Английский

Citations

86
Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders DOI Creative Commons
Miranda Mele, Rui O. Costa, Carlos B. Duarte

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: March 7, 2019

GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission central nervous system (CNS). Regulation of GABAAR trafficking and control their surface expression play important roles modulation strength synaptic inhibition. Different pieces evidence show that alterations distribution dysregulation turnover impair activity synapses. A diminished efficacy affects excitatory/inhibitory balance is a common feature various disorders CNS characterized by an increased excitability neuronal networks. The pool mainly controlled through regulation internalization, recycling lateral diffusion receptors. Under physiological condition these mechanisms finely coordinated to define GABAergic In this review article, we focus on alteration with impact function synapses CNS. particular discuss how similar molecular affecting consequently may be associated wide diversity pathologies CNS, from psychiatric acute leading death. better understanding cellular contribute impairment disorders, distribution, lead identification new pharmacological targets development novel therapeutic strategies.

Language: Английский

Citations

85
Neuroprotective Effects of Resveratrol in In vivo and In vitro Experimental Models of Parkinson’s Disease: a Systematic Review DOI
Michele Goulart dos Santos, Lúcia Emanueli Schimith, Corinne André‐Miral

et al.

Neurotoxicity Research, Journal Year: 2022, Volume and Issue: 40(1), P. 319 - 345

Published: Jan. 11, 2022

Language: Английский

Citations

49
Adipose tissue, systematic inflammation, and neurodegenerative diseases DOI Creative Commons
Ludovico Migliolo,

AnaPaula de A. Boleti,

Pedro Henrique de Oliveira Cardoso

et al.

Neural Regeneration Research, Journal Year: 2022, Volume and Issue: 18(1), P. 38 - 38

Published: July 9, 2022

Obesity is associated with several diseases, including mental health. Adipose tissue distributed around the internal organs, acting in regulation of metabolism by storing and releasing fatty acids adipokine tissues. Excessive nutritional intake results hypertrophy proliferation adipocytes, leading to local hypoxia adipose changes these releases. This leads recruitment immune cells release pro-inflammatory cytokines. The presence high levels free inflammatory molecules interfere intracellular insulin signaling, which can generate a neuroinflammatory process. In this review, we provide an up-to-date discussion how excessive obesity lead possible cognitive dysfunction. We also address idea that obesity-associated systemic inflammation neuroinflammation brain, particularly hypothalamus hippocampus, partially responsible for negative outcomes. addition, discuss some clinical models animal studies clarify mechanism action anti-obesity drugs central nervous system.

Language: Английский

Citations

46
Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson’s disease DOI Creative Commons
Yumin Wang, Shuang Wu, Qiang Li

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 12, 2022

Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from green tea extract, possesses versatile bioactivities that can combat many diseases. During the last decade, EGCG was shown to be effective in experimental models of Parkinson's disease (PD). Several studies have suggested it has pleiotropic neuroprotective effects, which enhanced appeal as a therapeutic strategy PD. In this review, we compiled recent updates and knowledge molecular mechanisms underlying effects We focused on apoptosis, oxidative stress, inflammation, ferroptosis, modulation dopamine production, aggregation α-synuclein. The review highlights pharmacological features its implications Taken together, accumulated data indicate is promising compound for treatment

Language: Английский

Citations

46
Plasmonic Coupling on an Optical Microfiber Surface: Enabling Single‐Molecule and Noninvasive Dopamine Detection DOI
Yunyun Huang, Pengwei Chen,

Luyan Zhou

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: June 21, 2023

Optical fibers can be effective biosensors when employed in early-stage diagnostic point-of-care devices as they avoid interference from molecules with similar redox potentials. Nevertheless, their sensitivity needs to improved for real-world applications, especially small-molecule detection. This work demonstrates an optical microfiber biosensor dopamine (DA) detection based on the DA-binding-induced aptamer conformational transitions that occur at plasmonic coupling sites a double-amplified nanointerface. The sensor exhibits ultrahigh detecting DA single-molecule level; additionally, this provides approach overcoming device limits, further extending fiber small molecule range (e.g., and metal ions). selective energy enhancement signal amplification binding effectively nonspecific of whole surface which may lead false-positive results. detect signals body-fluids. It released extracellular levels monitor oxidation process. An appropriate replacement allows used other target ions level. technology offers alternative opportunities developing noninvasive flexible techniques theoretical research.

Language: Английский

Citations

30
Recent Prospects of Carbonaceous Nanomaterials-Based Laccase Biosensor for Electrochemical Detection of Phenolic Compounds DOI Creative Commons
Sakshi Verma,

Deeksha Thakur,

Chandra Mouli Pandey

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 305 - 305

Published: Feb. 22, 2023

Phenolic compounds (PhCs) are ubiquitously distributed phytochemicals found in many plants, body fluids, food items, medicines, pesticides, dyes, etc. Many PhCs priority pollutants that highly toxic, teratogenic, and carcinogenic. Some of these present fluids affect metabolism, while others possess numerous bioactive properties such as retaining antioxidant antimicrobial activity plants products. Therefore, there is an urgency for developing effective, rapid, sensitive, reliable tool the analysis to address their environmental health concern. In this context, carbonaceous nanomaterials have emerged a promising material fabrication electrochemical biosensors they provide remarkable characteristics lightweight, high surface: volume, excellent conductivity, extraordinary tensile strength, biocompatibility. This review outlines current status applications (CNTs, graphene, etc.) based enzymatic detection PhCs. Efforts also been made discuss mechanism action laccase enzyme The limitations, advanced emerging carbon-based material, state artificial intelligence detection, future scopes summarized.

Language: Английский

Citations

26
Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction DOI Creative Commons
Masaru Tanaka, László Vécsei

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(12), P. 1367 - 1387

Published: Aug. 7, 2024

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like

Language: Английский

Citations

11
Cells, pathways, and models in dyskinesia research DOI Creative Commons
M. Angela Cenci, Arvind Kumar

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 84, P. 102833 - 102833

Published: Jan. 6, 2024

L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic movement disorder resulting from altered information processing in cortico-basal ganglia network. We here review recent advances clarifying interplay between striatal output pathways this disorder. also studies revealing structural and synaptic changes to microcircuitry cortico-striatal activity dynamics LID. furthermore highlight progress made understanding involvement cerebellar brain stem nuclei. These developments illustrate that research continues provide key insights into cellular circuit-level plasticity within network its interconnected regions.

Language: Английский

Citations

9