Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 340 - 340

Published: Dec. 25, 2022

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, tissue-protective properties which may be useful treatment various diseases, particularly cancer, neurological, cardiovascular, respiratory, metabolic disorders. This article reviews current information on biological effects above-mentioned disorders relation molecular pathways controlling inflammation, oxidative stress, apoptosis.

Language: Английский

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Ferroptosis: a new hunter of hepatocellular carcinoma

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 13, 2024

Abstract Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular lipid peroxidation that plays a key role in the development of HCC. Studies have shown various clinical agents (e.g., sorafenib) ferroptosis inducer-like effects and can exert therapeutic modulating different factors pathway. This implies targeting tumor may be very promising strategy for therapy. In this paper, we summarize prerequisites defense systems occurrence targets drug-mediated action HCC, differences connections between other programmed deaths. We aim to theoretical basis, classical inducers research progress HCC cells, clued treatment regulating network. Further investigation specific mechanisms hepatocellular carcinoma interventions at stages will help us deepen our understanding carcinoma, with view providing new more precise preventive as well measures patients.

Language: Английский

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Phytochemicals: a new arsenal in drug discovery

International Journal of Medical Science and Dental Health, Journal Year: 2024, Volume and Issue: 10(01), P. 29 - 44

Published: Jan. 1, 2024

In ancient times traditional herbs were used to treat different diseases such as stomach discomfort, toothache, body pain and inflammation, diarrhea, malaria, typhoid, diabetes, so on. Medicinally important plants are recognized have chemicals or phytochemicals that could be useful for illness treatment medication manufacture. These compounds occur naturally in plant parts (leaves, stems, barks, roots) referred secondary metabolites because, like primary metabolites, they synthesized protect the rather than growth. Fortunately humans, majority of these therapeutic properties against a variety health problems. Resistance antibiotics is one world's most critical challenges, with numerous infections rapidly gaining resistance conventional antimicrobials. There currently no viable agent ability reverse antimicrobial resistance, several leading laboratories working hard find new Plant-based chemical received comparatively little attention context development. Natural piqued interest drug development scientists because their structural diversity, novelty, abundance, bioactivity. Cancer major problem. Despite interventions available, huge number patients die each year result cancer disorders. The rising research direction healthcare pharmacy an effective side-effect-free anticancer medication. Chemical entities found proven particularly promising this area. Bioactive preferred act differentially on cells while leaving normal alone. This review provides overview utility medicinal well sources, discovery process, efficacy safety phytochemicals, current applications, developments screening technologies, future directions.

Language: Английский

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Synucleins: New Data on Misfolding, Aggregation and Role in Diseases

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3241 - 3241

Published: Dec. 13, 2022

The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins consisting α-, β-, and γ-synuclein involved in neurodegenerative diseases cancer. current number publications on has exceeded 16.000. They remain the subject constant interest for over 35 years. Two reasons explain this unchanging attention: synuclein's association with several severe human lack understanding functional roles under normal physiological conditions. We analyzed recent to look at main trends developments synuclein research discuss possible future directions. Traditional areas peak which still high among last year's comparative studies structural features as well three members family. Another popular topic area is mechanism α-synuclein accumulation, aggregation, fibrillation. Exciting fast-growing epigenetics. do not present here broad comprehensive review all directions but summarize only most significant findings relevant these topics outline potential

Language: Английский

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Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 212 - 212

Published: Jan. 7, 2023

Neurodegenerative diseases are caused by the gradual loss of neurons’ function. These neurological illnesses remain incurable, and current medicines only alleviate symptoms. Given social economic burden rising frequency neurodegenerative diseases, there is an urgent need for development appropriate therapeutics. Natural compounds gaining popularity as alternatives to synthetic drugs due their neuroprotective properties higher biocompatibility. While natural compounds’ therapeutic effects disease treatment have been investigated in numerous vitro vivo studies, few moved clinical trials. This article provides first systematic review trials evaluating safety efficacy five most prevalent disorders: Alzheimer’s disease, Parkinson’s multiple sclerosis, amyotrophic lateral Huntington’s disease.

Language: Английский

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Phytomedicine for neurodegenerative diseases: The road ahead

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 2993 - 3019

Published: April 10, 2024

Abstract Neurodegenerative disorders (NDs) are among the most common causes of death across globe. NDs characterized by progressive damage to CNS neurons, leading defects in specific brain functions such as memory, cognition, and movement. The Parkinson's, Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS). Despite extensive research, no therapeutics or medications against have been proven be effective. current treatment involving symptom‐based targeting disease pathogenesis has certain limitations, drug resistance, adverse side effects, poor blood–brain barrier permeability, bioavailability drugs. Some studies shown that plant‐derived natural compounds hold tremendous promise for treating preventing NDs. Therefore, primary objective this review article is critically analyze properties potency some studied phytomedicines, quercetin, curcumin, epigallocatechin gallate (EGCG), apigenin, cannabinoids, highlight their advantages limitations developing next‐generation alternative treatments Further research on pre‐clinical clinical plant‐based drugs from bench bedside warranted.

Language: Английский

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Inflammasomes in Alzheimer’s Progression: Nrf2 as a Preventive Target

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 121 - 121

Published: Jan. 21, 2025

Current knowledge about Alzheimer’s disease highlights the accumulation of β-amyloid plaques (Aβ1–42) and neurofibrillary tangles composed hyperphosphorylated Tau, which lead to loss neuronal connections. Microglial activation release inflammatory mediators play a significant role in progression pathology. Recent advances have identified involvement inflammasomes, particularly NOD-like receptor NLR family pyrin domain containing 3 (NLRP3), whose promotes proinflammatory cytokines triggers pyroptosis, exacerbating neuroinflammation. Aggregates Aβ1–42 Tau been shown activate these while apoptosis-associated speck-like protein (ASC) components form aggregates that further accelerate Aβ aggregation. Defects autophagic clearance inflammasomes also implicated disease, contributing sustained inflammation. This review explores strategies counteract inflammation Alzheimer’s, emphasizing degradation ASC specks inhibition NLRP3 inflammasome activation. Notably, nuclear factor erythroid 2-related 2 (Nrf2) transcription emerges as promising therapeutic target due its dual mitigating oxidative stress directly inhibiting formation. By reducing inflammasome-driven inflammation, Nrf2 offers potential for addressing neuroinflammatory aspects disease.

Language: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

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Gut–Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson’s Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2041 - 2041

Published: June 27, 2024

With the recognition of importance gut-brain axis in Parkinson's disease (PD) etiology, there is increased interest developing therapeutic strategies that target α-synuclein, hallmark abhorrent protein PD pathogenesis, which may originate gut. Research has demonstrated inhibiting aggregation, oligomerization, and fibrillation α-synuclein are key for modification. Polyphenols, rich fruits vegetables, drawing attention their potential role this context. In paper, we reviewed how polyphenols influence composition functional capabilities gut microbiota resulting microbial metabolites potentially enhance modulation aggregation. Understanding interaction between identifying specific microbes efficacy crucial precision nutrition based on microbiome.

Language: Английский

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Phytochemicals against Osteoarthritis by Inhibiting Apoptosis

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1487 - 1487

Published: March 27, 2024

Osteoarthritis (OA) is a chronic joint disease that causes pathological changes in articular cartilage, synovial membrane, or subchondral bone. Conventional treatments for OA include surgical and non-surgical methods. Surgical treatment suitable patients the terminal stage of OA. It often last choice because associated risks high cost. Medication mainly includes non-steroidal anti-inflammatory drugs, analgesics, hyaluronic acid, cortico-steroid drugs. However, these drugs have severe side effects cannot meet needs patients. Therefore, safe clinically appropriate long-term are urgently needed. Apoptosis programmed cell death, which kind physiologic suicide determined by heredity conserved evolution. Inhibition apoptosis-related pathways has been found to prevent treat variety diseases. Excessive apoptosis can destroy cartilage homeostasis aggravate process inhibition factors signaling become an effective means Phytochemicals active ingredients from plants, it phytochemicals play important role prevention inhibiting apoptosis. We summarize preclinical clinical studies The results show targeting pathways. On basis improving some with low bioavailability, poor water solubility, toxicity nanotechnology-based drug delivery systems, at same time undergoing strict pharmacological tests, be used as potential therapeutic may applied settings.

Language: Английский

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