Heritability and cross-species comparisons of human cortical functional organization asymmetry

eLife, Journal Year: 2022, Volume and Issue: 11

Published: July 29, 2022

The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. quantified contralateral homologous difference, that asymmetry, a key feature of the brain left-right axis supporting functional processes, such as language. Here, we assessed whether asymmetry cortical organization heritable phylogenetically conserved between humans macaques. Our findings indicate asymmetric an describing trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward organization, frontoparietal rightward humans. These asymmetries were similar spatial distribution with macaques, case intra-hemispheric hierarchy. This suggests (phylo)genetic conservation. However, both networks qualitatively larger relative Overall, our suggest genetic basis for intrinsic linked higher order cognitive functions uniquely developed

Language: Английский

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Experience sampling reveals the role that covert goal states play in task-relevant behavior

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 7, 2023

Cognitive neuroscience has gained insight into covert states using experience sampling. Traditionally, this approach focused on off-task states. However, task-relevant are also maintained via processes. Our study examined whether sampling can provide insights goal-relevant that support task performance. To address question, we developed a neural state space, dimensions of brain function variation, allows correlates overt and to be in common analytic space. We use describe activity during performance, its relation identified sampling, links between individual variation established deliberate focus was linked faster target detection, underlying experience-and detection-were associated with patterns emphasizing the fronto-parietal network. In contrast, experiences-and vigilance periods-were default mode shows not only unrelated at hand, but used highlight role regions play maintenance

Language: Английский

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A dynamic gradient architecture generates brain activity states

NeuroImage, Journal Year: 2022, Volume and Issue: 261, P. 119526 - 119526

Published: July 30, 2022

The human brain exhibits a diverse yet constrained range of activity states. While these states can be faithfully represented in low-dimensional latent space, our understanding the constitutive functional anatomy is still evolving. Here we applied dimensionality reduction to task-free and task fMRI data address whether dimensions reflect intrinsic systems if so, how may interact generate different We find that each dimension represents dynamic gradient, including primary unipolar sensory-association gradient underlying global signal. gradients appear stable across individuals cognitive states, while recapitulating key connectivity properties anticorrelation, modularity, regional hubness. then use dynamical modeling show causally via state-specific coupling parameters create distinct patterns. Together, findings indicate set dynamic, spatial determine repertoire possible

Language: Английский

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Linking cerebellar functional gradients to transdiagnostic behavioral dimensions of psychopathology

NeuroImage Clinical, Journal Year: 2022, Volume and Issue: 36, P. 103176 - 103176

Published: Jan. 1, 2022

High co-morbidity and substantial overlap across psychiatric disorders encourage a transition in psychiatry research from categorical to dimensional approaches that integrate neuroscience psychopathology. Converging evidence suggests the cerebellum is involved wide range of cognitive functions mental disorders. An important question thus centers on extent which cerebellar function can be linked transdiagnostic dimensions To address this question, we used multivariate data-driven statistical technique (partial least squares) identify latent linking human connectome as assessed by functional MRI large set clinical, cognitive, trait measures 198 participants, including healthy controls (n = 92) well patients diagnosed with attention-deficit/hyperactivity disorder 35), bipolar 36), schizophrenia 35). Macroscale spatial gradients connectivity at voxel level were characterize properties, provide low-dimensional representation connectivity, i.e., sensorimotor-supramodal hierarchical organization. This analysis revealed significant correlated patterns behavioral could represented into four dimensions: general psychopathology, impulsivity mood, internalizing symptoms executive dysfunction. Each dimension was associated unique pattern all participants. Multiple control analyses 10-fold cross-validation confirmed robustness generalizability yielded dimensions. These findings highlight relevance necessity for study classification psychopathology call researcher pay more attention role not just within cerebral cortex.

Language: Английский

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Gradients of connectivity as graph Fourier bases of brain activity

Network Neuroscience, Journal Year: 2021, Volume and Issue: 5(2), P. 322 - 336

Published: Jan. 1, 2021

Abstract The application of graph theory to model the complex structure and function brain has shed new light on its organization, prompting emergence network neuroscience. Despite tremendous progress that been achieved in this field, still relatively few methods exploit topology networks analyze activity. Recent attempts direction have leveraged one hand spectral analysis (to decompose connectivity into eigenmodes or gradients) other signal processing activity “coupled to” an underlying Fourier modes). These studies used a variety imaging techniques (e.g., fMRI, electroencephalography, diffusion-weighted myelin-sensitive imaging) estimators networks. Results are promising terms interpretability functional relevance, but methodologies terminology variable. goals paper twofold. First, we summarize recent contributions related gradients processing, attempt clarification while pointing out current methodological limitations. Second, discuss perspective relevance could be fruitfully exploited by considering them as bases

Language: Английский

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