Verbal working memory and syntactic comprehension segregate into the dorsal and ventral streams DOI Creative Commons
William Matchin,

Zeinab Khoshhal Mollasaraei,

Leonardo Bonilha

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

Abstract Syntactic processing and verbal working memory are both essential components to sentence comprehension. Nonetheless, the separability of these systems in brain remains unclear. To address this issue, we performed causal-inference analyses based on lesion connectome network mapping using MRI behavioral testing 103 individuals with chronic post-stroke aphasia. We employed a rhyme judgment task heavy load without articulatory confounds, controlling for overall ability match auditory words pictures perform metalinguistic judgment, isolating effect load. assessed noncanonical comprehension, syntactic by incorporating residual performance as covariate Voxel-based structural connectome-based symptom total volume were performed, permutation correct multiple comparisons (4,000 permutations). observed that effects localized dorsal stream damage: posterior temporal-parietal lesions frontal-parietal white matter disconnections. These differentiated from comprehension deficits, which primarily associated ventral temporal lobe disconnections, particularly when measure covariate. Our results support conclusion distinct networks, largely loading onto streams, respectively.

Language: Английский

Unveiling altered connectivity between cognitive networks and cerebellum in schizophrenia DOI

Margherita Biondi,

Marco Marino, Dante Mantini

et al.

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 271, P. 47 - 58

Published: July 15, 2024

Language: Английский

Citations

3
The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis DOI Creative Commons
Sabrina Beber,

Giorgia Bontempi,

Gabriele Miceli

et al.

Neuropsychology Review, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Abstract Lesion-symptom studies in persons with aphasia showed that left temporoparietal damage, but surprisingly not prefrontal correlates impaired ability to process thematic roles the comprehension of semantically reversible sentences ( The child is hugged by mother ). This result has led challenge time-honored view regions are critical for sentence comprehension. However, most focused on role assignment and failed consider morphosyntactic processes also processing. We reviewed meta-analyzed lesion-symptom neurofunctional processing production aphasia. Following PRISMA checklist, we selected 43 papers review 27 meta-analysis, identifying a set potential bias risks. Both meta-analysis confirmed correlation between clearly involvement Exploratory meta-analyses suggested both correlate regions, structures more than displays opposite trend. discuss current limitations literature propose recommendations clarifying unresolved issues.

Language: Английский

Citations

3
Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression DOI

Sangni Liu,

Dandan Fan,

Cancan He

et al.

European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
An innovation scalp acupuncture prescription for post-stroke aphasia：A Neuroimaging-Based validation study DOI Creative Commons

Minjie Xu,

Binlong Zhang,

Yuhang Chen

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111334 - 111334

Published: April 1, 2025

The coexistence of speech disorders in stroke patients can negatively impact their quality life and rehabilitation outcomes. Scalp acupuncture (SA) has shown potential as a non-pharmacological treatment for post-stroke aphasia (PSA). As the location SA PSA is controversial, this study aims to utilize neuroimaging techniques identifying validation promising target. was divided into two phases. In phase Ⅰ, three pipelines, including lesion mapping, meta-analysis, resting-state functional connectivity, were integrated targets. Ⅱ, Centro-square needling manipulations then applied evaluate prescription with PSA. left middle temporal gyrus (MTG) chosen one targets it had highest occurrence among outcomes pipelines. It been discovered that technique MTG immediately enhance reduced connectivity (FC) between frontal caused by diseases. Moreover, enhances FC superior gyrus, which may constitute therapeutic mechanism underlying its efficacy improving verb understanding scores on Chinese Rehabilitation Research Center Standard Aphasia Examination scale. summary, protocol integrating traditional medicine help refine locations

Language: Английский

Citations

0
Common and distinct patterns underlying different linguistic tasks: multivariate disconnectome symptom mapping in poststroke patients DOI
Yaya Jiang, Gaolang Gong

Cerebral Cortex, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Numerous studies have been devoted to neural mechanisms of a variety linguistic tasks (e.g. speech comprehension and production). To date, however, whether how the patterns underlying different are similar or differ remains elusive. In this study, we compared 3 mainly concerning production. address this, multivariate regression approaches with lesion/disconnection symptom mapping were applied data from 216 stroke patients damage left hemisphere. The results showed that could predict both poststroke scores production tasks; these exhibited shared regions on temporal pole hemisphere as well unique contributing prediction for each domain. Lower in associated lesions/abnormalities superior gyrus middle gyrus, while lower inferior parietal lobe frontal lobe. These suggested an important role ventral dorsal stream pathways (i.e. supporting dual model) highlighted applicability novel disconnectome-based cognitive neuroscience research.

Language: Английский

Citations

2
Four dimensions of naturalistic language production in aphasia after stroke DOI Creative Commons
Marianne Casilio, Anna Kasdan, Katherine M. Bryan

et al.

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Abstract There is a rich tradition of research on the neuroanatomical correlates spoken language production in aphasia using constrained tasks (e.g., picture naming), which offer controlled insights into distinct processes that govern speech and (i.e., lexical-semantic access, morphosyntactic construction, phonological encoding, motor programming/execution). Yet these do not necessarily reflect everyday use. In contrast, naturalistic (also referred to as connected or discourse) more closely approximates typical processing demands, requiring dynamic integration all aspects language. The brain bases remain relatively unknown, however, part because difficulty deriving features are salient, quantifiable, interpretable relative both speech-language extant literature. present cross-sectional observational study seeks address challenges by leveraging validated comprehensive auditory-perceptual measurement system yields four explanatory dimensions performance—Paraphasia (misselection words sounds), Logopenia (paucity words), Agrammatism (grammatical omissions), Motor (impaired We used this characterize large representative sample individuals with acute post-stroke (n = 118). Scores each were correlated lesion metrics, multivariate associations among regions then explored. Our findings revealed yet overlapping throughout left-hemisphere network. Paraphasia associated primarily posterior regions, spanning dorsal ventral streams, critical for access encoding. anterior stream involved construction planning/execution respectively. Collectively, we view results constituting brain-behavior model aphasia, aligning historical contemporary accounts neurobiology production.

Language: Английский

Citations

2
Symptomatology after damage to the angular gyrus through the lenses of modern lesion-symptom mapping DOI Creative Commons
Mohamed L. Seghier

Cortex, Journal Year: 2024, Volume and Issue: 179, P. 77 - 90

Published: Aug. 3, 2024

Language: Английский

Citations

2
Mapping sentence comprehension and syntactic complexity: evidence from 131 stroke survivors DOI Creative Commons
Nicoletta Biondo, Maria V. Ivanova,

Alexis L. Pracar

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(6)

Published: Jan. 1, 2024

Abstract Understanding and interpreting how words are organized in a sentence to convey distinct meanings is cornerstone of human communication. The neural underpinnings this ability, known as syntactic comprehension, far from agreed upon current neurocognitive models language comprehension. Traditionally, left frontal regions (e.g. posterior inferior gyrus) were considered critical, while more recently, temporal (most prominently, middle have been identified indispensable Syntactic processing has investigated by using different types non-canonical sentences i.e. those that do not follow prototypical word order syntactically complex. However, can be complex for linguistic reasons, thus, their comprehension might rely on underpinnings. In cross-sectional study, we explored the correlates investigating roles hemisphere brain white matter pathways with levels complexity. Participants assessed at single point time structural MRI behavioural tests. Employing lesion–symptom mapping indirect disconnection cohort 131 stroke survivors, our analysis revealed following underlying crucial general comprehension: mid-posterior superior gyrus, gyrus sulcus longitudinal fasciculus, fronto-occipital uncinate fasciculus tracts crossing most part corpus callosum. We further found significant involvement connecting lobes types. Spared connections between critical requiring long-distance retrieval (spared both subject object extraction spared arcuate extraction) but passive canonical declarative sentences. Our results challenge traditional emphasize primary role regions, such Broca’s area, basic structure findings suggest gradient complexity, rather than clear-cut dichotomy structures. contribute nuanced understanding architecture highlight potential directions future research.

Language: Английский

Citations

2
Lexico-semantics obscures lexical syntax DOI Creative Commons
William Matchin

Frontiers in Language Sciences, Journal Year: 2023, Volume and Issue: 2

Published: Aug. 9, 2023

OPINION article Front. Lang. Sci., 09 August 2023Sec. Neurobiology of Language Volume 2 - 2023 | https://doi.org/10.3389/flang.2023.1217837

Language: Английский

Citations

6
Cleaning up the Brickyard: How Theory and Methodology Shape Experiments in Cognitive Neuroscience of Language DOI Creative Commons
Constantijn L van der Burght, Angela D. Friederici, Matteo Maran

et al.

Journal of Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 35(12), P. 2067 - 2088

Published: Jan. 1, 2023

Abstract The capacity for language is a defining property of our species, yet despite decades research, evidence on its neural basis still mixed and generalized consensus difficult to achieve. We suggest that this partly caused by researchers “language” in different ways, with focus wide range phenomena, properties, levels investigation. Accordingly, there very little agreement among cognitive neuroscientists the operationalization fundamental concepts be investigated neuroscientific experiments. Here, we review chains derivation neuroscience language, focusing how hypothesis under consideration defined combination theoretical methodological assumptions. first attempt disentangle complex relationship between linguistics, psychology, field. Next, conclusions can drawn from any experiment are inherently constrained auxiliary assumptions, both methodological, which validity rests. These issues discussed context classical experimental manipulations as well study designs employ novel approaches such naturalistic stimuli computational modeling. conclude proposing highly interdisciplinary field requires form explicit statements concerning definitions, choices, other constraining factors involved their work.

Language: Английский

Citations

4