Quantitative susceptibility mapping of brain iron in healthy aging and cognition

NeuroImage, Journal Year: 2023, Volume and Issue: 282, P. 120401 - 120401

Published: Oct. 5, 2023

Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique that can assess the properties of cerebral iron in vivo. Although brain necessary for basic neurobiological functions, excess content disrupts homeostasis, leads to oxidative stress, and ultimately contributes neurodegenerative disease. However, some degree elevated present even among healthy older adults. To better understand topographical pattern accumulation its relation cognitive aging, we conducted systematic review 47 QSM studies with focus on five distinct themes. The first two themes focused age-related increases deep gray matter nuclei versus cortex. overall level higher than cortical regions. Deep vary regard effects, which are most prominent putamen, deposition also observed frontal, temporal, parietal regions during aging. third theme behavioral relevance indicated both was related decline fluid (speed-dependent) cognition. A handful multimodal studies, reviewed fourth theme, suggest interacts measures function, white degradation, neuropathologies. final concerning modifiers pointed potential roles cardiovascular, dietary, genetic factors. relatively recent tool assessing accumulation, it has significant promise contributing new insights into neurocognitive

Language: Английский

Nigrostriatal iron accumulation in the progression of Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 11, 2025

Iron deposition in the nigrostriatal system plays a pivotal role Parkinson's disease (PD) onset and progression. This study explored time course of iron accumulation 54 PD patients at early to moderately advanced stages 20 age-matched healthy controls. Using multi-echo T2*-MRI R2* relaxometry, content was assessed substantia nigra pars compacta (SNpc) striatum. In vivo findings were contrasted with histological analyses progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism model involving six non-human primates (NHPs) two controls using Perls' Prussian blue staining. Complementarily, dopaminergic degeneration quantified by 6-[18F]-fluoro-L-dopa PET humans TH immunohistochemistry NHPs. Results showed SNpc correlating striatal denervation neuronal loss. Striatal followed V-shaped progression, decreasing initially increasing later. may serve as marker neurodegeneration PD, while decreased indicate pathological susceptibility

Language: Английский

Radiomics score derived from T1-w/T2-w ratio image can predict motor symptom progression in Parkinson’s disease

European Radiology, Journal Year: 2024, Volume and Issue: 34(12), P. 7921 - 7933

Published: July 3, 2024

Language: Английский