Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Language: Английский
NeuroImage, Journal Year: 2024, Volume and Issue: 289, P. 120547 - 120547
Published: Feb. 18, 2024
Parkinson's disease (PD) is a common neurodegenerative disease, and apart from few rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has been captured by the involvement of iron biochemistry disruption homeostasis, particularly within brain regions specifically affected in PD. The advent Quantitative Susceptibility Mapping (QSM) enabled non-invasive quantification vivo MRI, which contributed to understanding iron-associated potential for development iron-based biomarkers This review elucidates biochemical underpinnings accumulation, details advancements iron-sensitive MRI technologies, discusses role QSM as biomarker deposition Despite considerable progress, several challenges impede clinical application after decade studies. initiation multi-site research warranted developing robust, interpretable, disease-specific monitoring PD progression.
Language: Английский
Citations
21
Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123732 - 123732
Published: March 8, 2024
The gut-brain axis is a crucial interface between the central nervous system and gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in microbiota, which may affect communication, impacting aspects of brain function behavior. This systematic review literature aims evaluate whether deleterious effects on due metal could be mediated by changes microbiota profile. Animal studies involving metals comparison with control group evaluated neuropsychological outcomes and/or molecular along analysis composition were reviewed. authors independently assessed for inclusion, extracted data risk bias using protocol Systematic Review Center Laboratory Experimentation (SYRCLE) preclinical studies. A search 3 databases yielded 16 eligible focused lead (n = 10), cadmium 1), mercury 3), manganese combined Pb Mn 1). animal species rats 7), mice 4), zebrafish carp 1) fruit fly Heavy found adversely cognitive function, behavior, neuronal morphology. Moreover, was associated abundance specific bacterial phyla, Firmicutes Proteobacteria, play roles health. In some studies, these alterations correlated learning memory impairments mood disorders. interplay suggests induce direct indirect through contributing neurotoxicity development However, small number papers under makes it difficult draw definitive conclusions. Further research warranted unravel underlying mechanisms translational implications human
Language: Английский
Citations
16
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Feb. 26, 2024
Introduction Alzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. This meta-analysis evaluated the use quantitative susceptibility mapping (QSM) to detect accumulation in deep gray matter (DGM) basal ganglia AD, contributing a better understanding AD progression, potentially leading new diagnostic therapeutic approaches. Methods Using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, Web Sciences, Google Scholar databases up October 2023 studies employing QSM research. Eligibility criteria were based on PECO framework, included assessing alterations magnetic indicative DGM patients with AD. After initial screening quality assessment using Newcastle-Ottawa Scale, was conducted compare levels between healthy controls (HCs) random-effects model. Results The nine comprising 267 272 HCs. There significantly higher values, indicating greater deposition, putamen (standardized mean difference (SMD) = 1.23; 95% CI: 0.62 1.84; p 0.00), globus pallidus (SMD 0.79; 0.07 1.52; 0.03), caudate nucleus 0.72; 0.39 1.06; 0.00) compared However, no significant differences found thalamus 1.00; −0.42 2.43; 0.17). sensitivity analysis indicated that single study impacted overall results. Age identified major contributor heterogeneity across all nuclei subgroup analysis. Older age (>69 years) lower male percentage (≤30%) associated increase Conclusion suggests excessive deposition is linked especially putamen. underscores complex nature pathology iron, influenced age, sex, regional differences, necessitating further research comprehensive understanding.
Language: Английский
Citations
12
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e27950 - e27950
Published: March 26, 2024
Magnetic resonance imaging (MRI) techniques, such as quantitative susceptibility mapping (QSM) and susceptibility-weighted (SWI), can detect iron deposition in the brain. Iron accumulation putamen (PUT) contribute to pathogenesis of Parkinson's disease (PD) atypical Parkinsonian disorders. This systematic review aimed synthesize evidence on PUT assessed by MRI techniques PD Parkinsonism syndromes. The PubMed Scopus databases were searched for relevant studies. Thirty-four studies from January 2007 October 2023 that used QSM, SWI, or other methods measure putaminal PD, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), healthy controls (HCs) included. Most have found increased levels patients versus HCs based higher susceptibility. Putaminal correlates with worse motor scores cognitive decline PD. Evidence regarding differences between is emerging, several showing greater PSP MSA than patients. Alterations help distinguish these disorders Increased appear be associated severity progression. Thus, magnetic abnormal Parkinsonism. Moreover, quantifying may serve an biomarker monitor changes aid differential diagnosis
Language: Английский
Citations
12
Brain, Journal Year: 2024, Volume and Issue: 147(11), P. 3665 - 3680
Published: July 22, 2024
Abstract The interaction between ageing and multiple sclerosis is complex carries significant implications for patient care. Managing effectively requires an understanding of how impact brain structure function. Ageing inherently induces changes, including reduced plasticity, diminished grey matter volume, ischaemic lesion accumulation. When combined with pathology, these age-related alterations may worsen clinical disability. also influence the response patients to therapies and/or their side effects, highlighting importance adjusted treatment considerations. MRI highly sensitive age- sclerosis-related processes. Accordingly, can provide insights into relationship sclerosis, enabling a better pathophysiological interplay informing selection. This review summarizes current knowledge on immunopathological aspects in CNS context sclerosis. Starting from immunosenescence, ageing-related pathological mechanisms specific features like enlarged Virchow-Robin spaces, this then explores aspects, late-onset age diagnostic criteria, comorbidity effects imaging features. role neurodegeneration, iron dynamics myelin changes influenced by contribute defining patients, are discussed.
Language: Английский
Citations
10
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: March 4, 2025
It is now understood that iron crosses the blood-brain barrier via a complex metabolic regulatory network and participates in diverse critical biological processes within central nervous system, including oxygen transport, energy metabolism, synthesis catabolism of myelin neurotransmitters. During brain development, distributed throughout brain, playing pivotal role key such as neuronal myelination, neurotransmitter synthesis. In physiological aging, can selectively accumulate specific regions, impacting cognitive function leading to intracellular redox imbalance, mitochondrial dysfunction, lipid peroxidation, thereby accelerating aging associated pathologies. Furthermore, accumulation may be primary contributor neurodegenerative diseases Alzheimer's Parkinson's diseases. Comprehending diseases, utilizing iron-sensitive Magnetic Resonance Imaging (MRI) technology for timely detection or prediction abnormal neurological states, implementing appropriate interventions instrumental preserving normal system function.
Language: Английский
Citations
1
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12
Published: July 3, 2024
: Previous studies have suggested a link between dysregulation of cortical iron levels and neuronal loss in amyotrophic lateral sclerosis (ALS) patients. However, few reported differences quantitative susceptibility mapping (QSM) values subcortical nuclei patients with ALS healthy controls (HCs).
Language: Английский
Citations
7
Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 689 - 689
Published: April 16, 2024
Elevated levels of iron occur in both cortical and subcortical regions the CNS patients with Alzheimer’s disease. This accumulation is present early disease process as well more advanced stages. The factors potentially accounting for this increase are numerous, including: (1) Cells their uptake reduce export iron, becomes sequestered (trapped within lysosome, bound to amyloid β or tau, etc.); (2) metabolic disturbances, such insulin resistance mitochondrial dysfunction, disrupt cellular homeostasis; (3) inflammation, glutamate excitotoxicity, other pathological disturbances (loss neuronal interconnections, soluble β, etc.) trigger cells acquire iron; (4) following neurodegeneration, trapped microglia. Some these mechanisms also neurological disorders can begin course, indicating that a relatively common event conditions. In response pathogenic processes, directed efforts contribute buildup reflect importance correcting functional deficiency support essential biochemical processes. words, prioritize an insufficiency available while tolerating deposited iron. An analysis disease, relevant conditions, put forward.
Language: Английский
Citations
5
Aging Medicine, Journal Year: 2024, Volume and Issue: 7(5), P. 649 - 667
Published: Oct. 1, 2024
Abstract Alzheimer's disease (AD) is a neurodegenerative that characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral body iron dysregulation accumulation interact with AD pathology, particularly in the precuneus, crucial functional hub cognitive functions. Quantitative susceptibility mapping (QSM), novel post‐processing approach, provides insights into tissue levels oxygen metabolism reveals abnormal early AD. Increased deposition precuneus can lead to oxidative stress, neuroinflammation, accelerated neurodegeneration. Metabolic disorders (diabetes, non‐alcoholic fatty liver (NAFLD), obesity), genetic factors, small vessel pathology contribute precuneus. Therefore, line growing of literature region patients AD, QSM as neuroimaging method could serve non‐invasive biomarker track progression, complement other imaging modalities, aid diagnosis monitoring.
Language: Английский
Citations
5
Brain Imaging and Behavior, Journal Year: 2024, Volume and Issue: 18(5), P. 1239 - 1255
Published: May 17, 2024
Language: Английский
Citations
4