Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

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Cross‐species translational paradigms for assessing positive valence system as defined by the RDoC matrix

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 169(1)

Published: Oct. 28, 2024

Abstract Functions associated with processing reward‐related information are fundamental drivers of motivation, learning, and goal‐directed behavior. Such functions have been classified as the positive valence system under Research Domain Criteria (RDoC) criteria negatively impacted across a range psychiatric disorders mental illnesses. The is composed three comprehensive categories containing related but dissociable that organized into either Reward Responsiveness, Learning, or Valuation. presence overlapping behavioral dysfunction diagnostic in‐part what motivated RDoC initiative, which emphasized study illness focus on investigating relevant behavior cognitive their underlying mechanisms, rather than separating efforts (i.e., transdiagnostic). Moreover, approach well‐suited for preclinical neuroscience research, rise in genetic toolboxes neurotechnologies enables researchers to probe specific cellular targets high specificity. Thus, there an opportunity dissect whether behaviors supported by shared distinct neural mechanisms. For research effectively inform our understandings human however, paradigms should predictive, neurobiological, pharmacological predictive validity test. Touchscreen‐based testing systems provide further advantage this endeavor enabling tasks be presented animals using same media task design humans. Here, we outline primary review work has done cross‐species investigate neurobiology neurochemistry functioning. Additionally, clinical outlined RDoC, along and/or need validation analogous rodent implementing touchscreen‐based systems. image

Language: Английский

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Elevated Loss Sensitivity in the Reward Circuit in Adolescents with Video Game but not Social Media Addiction

Computers in Human Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 108554 - 108554

Published: Jan. 1, 2025

Language: Английский

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Blunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Background and Hypothesis Among individuals living with psychotic disorders, social impairment is common, debilitating, challenging to treat. While the roots of this are undoubtedly complex, converging lines evidence suggest that motivation pleasure (MAP) deficits play a central role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences. Study Design Here we leveraged parallel incentive delay functional magnetic resonance imaging paradigms test whether blunted reactivity incentives in ventral striatum—a key component distributed neural circuit mediating appetitive hedonic pleasure—is associated more severe MAP symptoms transdiagnostic adult sample enriched for psychosis. To maximize ecological validity translational relevance, capitalized naturalistic audiovisual clips an established partner expressing positive feedback. Results Although both robustly engaged striatum, only was clinician-rated deficits. This association remained significant when controlling other symptoms, binary diagnostic status, or striatal incentives. Follow-up analyses suggested predominantly reflects diminished activation during presentation reward. Conclusions These observations provide neurobiologically grounded framework conceptualizing social-anhedonia impairments characterize many disorders underscore need develop targeted intervention strategies.

Language: Английский

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Altered neural signalling during reward anticipation in children and early adolescents with high psychotic-like experiences

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 45, P. 103756 - 103756

Published: Jan. 1, 2025

Schizophrenia is associated with abnormalities in neurodevelopmental processes. Furthermore, dysfunctional neural circuits involved reward processing may be linked to the development of symptoms schizophrenia and are predictive long-term functional outcome. It however unknown whether signatures anticipation detectable children high psychotic-like experiences. Using data from ABCD study 4.1, we defined a healthy control (N = 50) experience group Prodromal Psychosis Syndrome (PPS) score > 3 distress 6 at baseline (9-10 years) 2nd year follow-up (11-12 years). While undergoing MR-imaging, all completed Monetary Incentive Delay task. preprocessed ABCD-data, explored behaviour brain activations for loss areas underlying differed between groups time-points. investigated those that showed differences were later PPS scores. Additionally, also employed computational modelling assess response vigour. times did not differ, model revealed vigour salient cues was significantly lower PLEs compared controls baseline. We found demonstrated activation during anterior insula time-point; nucleus accumbens, putamen, dorsolateral (dlPFC) ventral medial prefrontal cortex follow-up, caudate both timepoints, controls. Regression analysis deactivations left dlPFC, This reveals alterations PLEs. These dysfunctions patterns serve as potential biomarkers psychosis.

Language: Английский

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Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Abstract Signalling at dopamine D2/D3 receptors is thought to underlie motivated behaviour, pleasure experiences and emotional expression based on animal studies, but it unclear if this the case in humans or how relates neural processing of reward stimuli. Using a randomised, double-blind, placebo-controlled, crossover neuroimaging study, we show healthy that sustained receptor antagonism for 7 days results negative symptoms (impairments hedonic experience, verbal expression) related blunted striatal response In contrast, partial agonism does not disrupt signalling, behaviour experience. Both induce motor impairments, which are response. These findings identify central role signalling mechanism underlying responses humans, with implications understanding neuropsychiatric disorders such as schizophrenia Parkinson’s disease.

Language: Английский

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Towards a Neurobiologically-driven Ontology of Mental Functions: A Data-driven Summary of the Twenty Years of Neuroimaging Meta-Analyses

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 30, 2023

ABSTRACT A persistent effort in neuroscience has been to pinpoint the neurobiological substrates that support mental processes. The Research Domain Criteria (RDoC) aims develop a new framework based on fundamental dimensions. However, results from several meta-analysis of task-based fMRI showed substantial spatial overlap between processes including emotion and anticipatory processes, irrespectively valence. Consequently, there is crucial need better characterize core using data-driven techniques, given these analytic approaches can capture across neuroimaging literature may not be identifiable through expert-driven categories. Therefore, we sought examine main co-activation networks past 20 years published meta-analyses studies. We manually extracted 19,822 coordinates 1,347 identified meta-analytic experiments. Correlation-Matrix-Based Hierarchical Clustering was conducted similarity experiments, identify networks. Activation likelihood estimation then used spatially convergent brain regions experiments each network. Across meta-analyses, found 13 which were further characterized by various psychological terms distinct association with receptor density maps intrinsic functional connectivity At activation resolution, seem more similar than different functions. discussed potential limitation linking labels investigated avenues tackle this long-lasting research question.

Language: Английский

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The Impact of Energy-Dense Food Consumption on Neural Response to Alcohol Rewards

Published: Jan. 1, 2025

Language: Английский

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Neural responses to reward valence and magnitude from pre- to early adolescence

NeuroImage, Journal Year: 2023, Volume and Issue: 275, P. 120166 - 120166

Published: May 12, 2023

Neural activation during reward processing is thought to underlie critical behavioral changes that take place the transition adolescence (e.g., learning, risk-taking). Though literature on neural basis of in booming, important gaps remain. First, more information needed regarding functional neuroanatomy early adolescence. Another gap understanding whether sensitivity different aspects incentive magnitude and valence) into We used fMRI from a large sample preadolescent children characterize responses valence vs. anticipation feedback, their change over period two years.

Language: Английский

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Appetitive conditioning with pornographic stimuli elicits stronger activation in reward regions than monetary and gaming‐related stimuli

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(8)

Published: May 26, 2024

Abstract Appetitive conditioning plays an important role in the development and maintenance of pornography‐use gaming disorders. It is assumed that primary secondary reinforcers are involved these processes. Despite common use pornography general population appetitive processes this context still not well studied. This study aims to compare using (pornographic) (monetary gaming‐related) rewards as unconditioned stimuli (UCS) population. Additionally, it investigates with gaming‐related type UCS was used previous studies. Thirty‐one subjects participated a differential procedure which four geometric symbols were paired either pornographic, monetary, or nothing become conditioned (CS + porn , CS game money CS−) functional magnetic resonance imaging study. We observed elevated arousal valence ratings skin conductance responses for each CS+ condition compared CS−. On neural level, we found activations during presentation bilateral nucleus accumbens, right medial orbitofrontal cortex, ventral anterior cingulate cortex CS−, but no significant These results indicate different emerge depending on whether presented separately together same experimental paradigm. monetary seem have lower value than pornographic rewards.

Language: Английский

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