Combining transcranial magnetic stimulation with training to improve social cognition impairment in schizophrenia: a pilot randomized controlled trial

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Schizophrenia is a severe, chronic mental disorder that profoundly impacts patients’ everyday lives. The illness’s core features include positive and negative symptoms cognitive impairments. In particular, deficits in the social cognition domain showed tighter connection to functioning than other symptoms. Social remediation interventions have been developed, providing heterogeneous results considering possibility of generalizing acquired improvements daily activities. this pilot randomized controlled trial, we investigated feasibility combining fifteen training sessions with non-invasive brain stimulation boost effectiveness two interventions. We delivered intermittent theta burst (iTBS) over left dorsolateral prefrontal cortex (DLPFC). Twenty-one patients were into four groups, varying for assigned condition (real vs. sham iTBS) type intervention (training no training). Clinical tests administered at five time points, i.e., before after treatment, three follow-ups one, three, six months treatments’ end. Preliminary data show trend improving competence managing emotion participants performing training. Conversely, differences found pre post-treatment scores recognition, theory mind, attribution intentions scores. iTBS did not induce additional effects on individuals’ performance. methodological approach’s novelty limitations present study are discussed.

Language: Английский

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Top-down and bottom-up stimulation techniques combined with action observation treatment in stroke rehabilitation: a perspective

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: July 11, 2023

Stroke is a central nervous system disease that causes structural lesions and functional impairments of the brain, resulting in varying types, degrees dysfunction. The bimodal balance-recovery model (interhemispheric competition vicariation model) has been proposed as mechanism recovery after stroke. We analyzed how combinations motor observation treatment approaches, transcranial electrical (TES) or magnetic (TMS) stimulation peripheral (PES) (PMS) techniques can be taken accessorial physical therapy methods on symptom reduction stroke patients. suggest top-down bottom-up combined with action synergistically might develop into valuable strategies neurorehabilitation explored TES TMS intervention over contralesional hemisphere lesioned PES PMS paretic limbs during followed by execution have super-additive effects to potentiate effect conventional paradigm could an innovative adjunctive approach rehabilitation treatment, especially for those patients severe deficits.

Language: Английский

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Betting on Non-Invasive Brain Stimulation to Treat Gambling Disorder: A Systematic Review and Meta-Analysis

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(4), P. 698 - 698

Published: April 21, 2023

Gambling disorder (GD) is a behavioral addiction that severely impacts individuals’ functioning, leading to high socioeconomic costs. Non-invasive brain stimulation (NiBS) has received attention for treating psychiatric and neurological conditions in recent decades, but there no recommendation its use GD. Therefore, this study aimed systematically review analyze the available literature determine effectiveness of NiBS Following PRISMA guidelines, we screened four electronic databases up July 2022 selected relevant English-written original articles. We included ten papers systematic seven meta-analysis. As only two studies employed sham-controlled design, pre–post standardized mean change (SMCC) was computed as effect size real stimulation. The results showed significant reducing craving scores (SMCC = −0.69; 95% CI [−1.2, −0.2], p 0.010). Moreover, considering GD’s frequent comorbidity with mood disorders, ran an exploratory analysis effects on depressive symptoms, which decreases post-treatment −0.71; [−1.1, −0.3], < 0.001). These provide initial evidence developing feasible therapy GD symptoms further comprehensive research needed validate these findings. limitations are critically discussed.

Language: Английский

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Neuromodulatory Treatment for Dizziness and Chronic Neurological Dysfunction in an Elderly Patient Using Radio Electric Asymmetric Conveyer (REAC) Neuro Psycho Physical Optimization (NPPO) Gamma Brain Wave Optimization (BWO-G): A Case Report

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

An 88-year-old woman presented with a longstanding history of dizziness, tremors, and progressive mental physical decline, significantly impairing her mobility autonomy. Recently discharged from an ICU, the patient required extensive support for daily activities. Diagnostic evaluations, including EEG analysis, revealed irregular frequency peaks altered cortical activity, particularly in frontal prefrontal regions. The underwent cycle 18 sessions radio electric asymmetric conveyer (REAC) Neuro Psycho Physical Optimization (NPPO) gamma brain wave optimization (BWO-G), neuromodulatory treatment aimed at restoring neurophysiological balance. Post-treatment, demonstrated marked clinical improvements, enhanced gait stability, reduced improved cognitive function. Electroencephalography (EEG) standardized low-resolution electromagnetic tomography (sLORETA) analysis confirmed these showing normalized activity patterns Brodmann areas 6, 24, 31, 4, 32. This case highlights potential REAC NPPO BWO-G addressing chronic neurological dysfunction improving quality life elderly patients. Furthermore, broader applicability this suggests benefits managing similar conditions aging populations, such as Parkinson's disease, age-related post-stroke rehabilitation, where bioelectrical dysregulation plays central role.

Language: Английский

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Reduction of rejection‐related emotions by transcranial direct current stimulation over right ventrolateral prefrontal cortex in borderline personality disorder: A double‐blind randomized pilot study

Psychiatry and Clinical Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Borderline personality disorder (BPD) patients show negative emotional reactions to both excluding and including social scenarios, with levels normalizing only during extreme inclusion. Prior research among healthy individuals highlights the right ventrolateral prefrontal cortex (rVLPFC) role in regulating responses exclusion, since transcranial direct current stimulation (tDCS) of rVLPFC decreases rejection-related emotions following exclusion. This pilot study investigated whether, BPD patients, tDCS over reduces not after exclusion but also fair Forty randomly received either real or sham on before participating Cyberball paradigm, which involved phases inclusion, over-inclusion. Participants self-reported their level each phase. Transcranial reduced Specifically, those Real group exhibited comparable over-including unlike Sham who experienced heightened inclusion compared patients' tendency feel rejected fairly scenarios. These findings confirm involvement regulation highlight a therapeutic potential for moderating BPD's typical supports application treatment, providing new insights into neuromodulatory interventions that can aid better regulate varying

Language: Английский

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Transcutaneous and transcranial electrical stimulation for enhancing military performance: an update and systematic review

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 3, 2025

Introduction Electrical stimulation (ES), including transcranial electrical (tES) and transcutaneous vagus nerve (tVNS), has shown potential for cognitive enhancement in military contexts. Various types of ES, such as direct current (tDCS) alternating (tACS), modulate neuronal membrane potentials cortical excitability, potentially improving functions relevant to training operations. Methods This systematic review updates previous findings by examining studies published between 2019 2024 that investigated effects on performance personnel tasks. We focused whether the addressed key questions about generalizability lab tasks, frequency intensity adverse effects, impact repeated ES administration, ethical regulatory considerations its use vulnerable populations. Results Eleven met inclusion criteria; most demonstrated overall low some concerns, however, two these had high risk bias. While tES tVNS showed promise enhancing multitasking visual search performance, results were mixed, with no reliable vigilance Discussion The reviewed highlight need a better understanding mechanisms, optimal parameters, individual differences response ES. They also importance conducting high-powered research settings evaluate efficacy, safety, implications Future should address lab-based real-world monitor explore long-term impacts administration. Furthermore, are crucial responsible application contexts, series outstanding is posed guide continuing this domain.

Language: Английский

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Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic-Ventrolateral Preoptic Projections

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(1), P. 105 - 105

Published: Jan. 22, 2024

Transcranial direct current stimulation (tDCS) is acknowledged for its non-invasive modulation of neuronal activity in psychiatric disorders. However, application insomnia research yields varied outcomes depending on different tDCS types and patient conditions. Our primary objective to elucidate efficiency uncover the underlying mechanisms treatment. We hypothesized that anodal prefrontal cortex activates glutamatergic projections from infralimbic (IL) ventrolateral preoptic area (VLPO) promote sleep. After administering 0.06 mA electrical currents 8 min, our results indicate significant non-rapid eye movement (NREM) enhancement naïve mice within initial 3 h post-stimulation, persisting up 16–24 h. In group, enhanced NREM sleep bout numbers during acute stress response improved REM duration subsequent insomnia. Sleep quality, assessed through delta powers, remains unaffected. Interference IL-VLPO pathway, utilizing designer receptors exclusively activated by drugs (DREADDs) with cre-DIO system, partially blocked tDCS’s improvement stress-induced This study elucidated activation pathway mediates effect These findings support understanding effects disturbances, providing valuable insights future clinical applications therapy.

Language: Английский

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Intermittent Theta Burst Stimulation Combined with Cognitive Training to Improve Negative Symptoms and Cognitive Impairment in Schizophrenia: A Pilot Study

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 683 - 683

Published: July 8, 2024

Schizophrenia is a chronic psychiatric disorder severely affecting patients’ functioning and quality of life. Unlike positive symptoms, cognitive impairment negative symptoms cannot be treated pharmacologically represent consistent predictors the illness’s prognosis. Cognitive remediation (CR) interventions have been applied to target these symptoms. Brain stimulation also provides promising yet preliminary results in reducing whereas its effect on remains heterogeneous. Here, we combined intermittent theta burst (iTBS) with CR improve schizophrenia spectrum patients. One hundred eligible patients were invited, twenty-one participated. We randomized them into four groups, manipulating condition (real vs. sham) (no training training). delivered fifteen iTBS sessions over left dorsolateral prefrontal cortex for three weeks, followed (or not) by 50 min training. Consensus-based clinical assessment was administered at baseline after treatment, plus follow-ups occurring one, three, six months intervention. Mixed-model analyses run symptom scores. The findings highlighted marginal modulation improved isolated functions. herein discuss limitations strengths methodological approach.

Language: Английский

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Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic Cortex-Ventrolateral Preoptic Area Projections

Published: Jan. 15, 2024

Transcranial direct current stimulation (tDCS) is acknowledged for its non-invasive modulation of neuronal activity in psychiatric disorders. However, application insomnia research yields varied outcomes depending on different tDCS types and patient conditions. Our primary objective to elucidate efficiency uncover the underlying mechanisms treatment. We hypothesized that anodal prefrontal cortex activates glutaminergic projections from infralimbic (IL) ventrolateral preoptic area (VLPO) promote sleep. After administering 0.06 mA electrical currents 8 minutes, our results indicate significant non-rapid eye movement (NREM) enhancement naïve mice within initial 3 hours post-stimulation, persisting up 16-24 hours. In group, enhanced NREM sleep bout numbers during acute stress response improved REM duration subsequent insomnia. Sleep quality, assessed through delta powers, remains unaffected. Interference IL-VLPO pathway, utilizing designer receptors exclusively activated by drugs (DREADDs) with cre-DIO system, partially blocked tDCS&#039;s improvement stress-induced This study elucidated activation pathway mediates effect These findings support understanding effects disturbances, providing valuable insights future clinical applications therapy.

Language: Английский

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Beyond the Surface: Deep TMS Efficacy in Reducing Craving in Addictive Disorders. A Systematic Review and Meta-analysis

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

ABSTRACT Background Substance use disorders (SUDs) and Gambling Disorder (GD) are addictive with a chronic course. Given the limited efficacy of conventional treatments, there is increasing interest in alternative strategies targeting altered neural circuits associated disease. In this context, deep Transcranial Magnetic Stimulation (dTMS) has emerged as novel neuromodulation technique capable reaching brain regions. However, no definite recommendation for its addiction treatment exists. This study systematically reviewed quantitatively analyzed dTMS effects SUDs GD populations. Methods Following PRISMA guidelines, we screened four electronic databases up to February 2024 selected relevant English-written original research articles. 17 papers were included systematic review. As only minority studies employed sham-controlled design, ran meta-analysis on subset 12 studies, computing pre-post real stimulation standardized mean change (SMCC) effect size, using self-reported craving scores dependent variable. Results The results showed significant large active reducing (SMCC = - 1.26, 95% CI [-1.67, 0.86], p <.001). High heterogeneity at both quantitative qualitative levels across was found, focusing different types one gambling behaviors. Conclusions provide initial evidence feasibility care. further comprehensive needed unveil several methodological challenges. limitations available literature future directions critically discussed.

Language: Английский

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