Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Creative Commons
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

ABSTRACT Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Language: Английский

Fundamentals of sleep regulation: Model and benchmark values for fractal and oscillatory neurodynamics DOI Creative Commons
Róbert Bódizs, Bence Schneider, Péter P. Ujma

et al.

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 234, P. 102589 - 102589

Published: March 1, 2024

Homeostatic, circadian and ultradian mechanisms play crucial roles in the regulation of sleep. Evidence suggests that ratios low-to-high frequency power electroencephalogram (EEG) spectrum indicate instantaneous level sleep pressure, influenced by factors such as individual sleep-wake history, current stage, age-related differences brain topography characteristics. These effects are well captured reflected spectral exponent, a composite measure constant ratio periodogram, which is scale-free exhibits lower interindividual variability compared to slow wave activity, potentially serving suitable standardization reference measure. Here we propose an index homeostasis based on reflecting membrane hyperpolarization and/or network bistability central nervous system humans. In addition, advance idea U-shaped overnight deceleration oscillatory fast spindle frequencies marks biological night, providing somnologists with EEG-index regulation. supporting this assertion comes from studies replacement, forced desynchrony protocols high-resolution analyses spindles. Finally, regulatory indicated recurrent, abrupt shifts dominant frequencies, ranges signifying non-rapid eye movement non-spindle oscillations – rapid phases cycles. Reconsidering indicators fundamental processes framework new Fractal Oscillatory Adjustment Model (FOAM) offers appealing opportunity bridge gap between two-process model clinical somnology.

Language: Английский

Citations

16
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Open Access
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

et al.

Published: March 13, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Language: Английский

Citations

1
The Temporal Dynamics of Aperiodic Neural Activity Track Changes in Sleep Architecture DOI Creative Commons
Mohamed S. Ameen, Joshua Jacobs, Manuel Schabus

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 26, 2024

Abstract The aperiodic (1/f-like) component of electrophysiological data - whereby power systematically decreases with increasing frequency, as quantified by the exponent has been shown to differentiate sleep stages. Earlier work, however, typically focused on measuring across a narrow frequency range. In this we sought further investigate activity during extending these analyses broader ranges and considering alternate model definitions. This included ‘knees’ in component, which reflect bends spectrum, indicating change exponent. We also evaluate temporal dynamics sleep. To do so, analyzed from two sources: intracranial EEG (iEEG) 106 epilepsy patients high-density 17 healthy individuals, measured activity, explicitly comparing different forms. doing find that fitting broadband models incorporating ‘knee’ feature effectively captures sleep-stage-dependent differences well relate stage transitions responses external stimuli. particular, knee parameter shows stage-specific variation, suggesting an interpretation varying timescales These results demonstrate examining more complex reveals novel insights interpretations for understanding neural

Language: Английский

Citations

7
The biological role of local and global fMRI BOLD signal variability in human brain organization DOI Creative Commons
Giulia Baracchini,

Yigu Zhou,

Jason da Silva Castanheira

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 23, 2023

Variability drives the organization and behavior of complex systems, including human brain. Understanding variability brain signals is thus necessary to broaden our window into function behavior. Few empirical investigations macroscale signal have yet been undertaken, given difficulty in separating biological sources variance from artefactual noise. Here, we characterize temporal most predominant signal, fMRI BOLD systematically investigate its statistical, topographical neurobiological properties. We contrast acquisition protocols, integrate across histology, microstructure, transcriptomics, neurotransmitter receptor metabolic data, static connectivity, simulated magnetoencephalography data. show that represents a spatially heterogeneous, central property multi-scale multi-modal organization, distinct Our work establishes relevance provides lens on stochasticity spatial scales.

Language: Английский

Citations

15
Aperiodic and Hurst EEG exponents across early human brain development: A systematic review DOI Creative Commons
Ryan A. Stanyard, Dan Mason, Claire L. Ellis

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 68, P. 101402 - 101402

Published: June 7, 2024

In electroencephalographic (EEG) data, power-frequency slope exponents (1/f_β) can provide non-invasive markers of in vivo neural activity excitation-inhibition (E:I) balance. E:I balance may be altered neurodevelopmental conditions; hence, understanding how 1/f β evolves across infancy/childhood has implications for developing early assessments/interventions. This systematic review (PROSPERO-ID: CRD42023363294) explored the maturation (0-26 yrs) resting-state EEG measures (aperiodic [AE], power law [PLE] and Hurst [HE] exponents), including studies containing ≥1 ≥10 typically participants. Five databases (including Embase Scopus) were searched during March 2023. Forty-two identified (Nparticipants=3478). Risk bias was assessed using Quality Assessment with Diverse Studies tool. Narrative synthesis HE data suggests non-stationary occurs throughout development. Age-related trends complex, rapid decreases AEs infancy heterogenous changes thereafter. Regionally, AE maxima shifted developmentally, potentially reflecting spatial maturing brain connectivity. work highlights importance further characterising development to better understand shapes cognitive

Language: Английский

Citations

6
Embracing sleep-onset complexity DOI Open Access
Célia Lacaux, Mélanie Strauss, Tristán A. Bekinschtein

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 273 - 288

Published: March 21, 2024

Language: Английский

Citations

5
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Open Access
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

et al.

Published: Jan. 6, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Language: Английский

Citations

0
Gestational Duration and Postnatal Age‐Related Changes in Aperiodic and Periodic Parameters in Neonatal and Toddler Electroencephalogram (EEG) DOI Creative Commons
Silja Luotonen, Henry Railo, Henriette Acosta

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(1)

Published: Jan. 1, 2025

ABSTRACT The brain develops most rapidly during pregnancy and early neonatal months. While prior electrophysiological studies have shown that aperiodic activity undergoes changes across infancy to adulthood, the role of gestational duration in periodic remains unknown. In this study, we aimed bridge gap by examining associations between EEG power spectrum both neonates toddlers. This cross‐sectional study involved data from 73 (postnatal age 1–5 days, 40 females) 56 toddlers 2.9–3.2 years, 28 FinnBrain Birth Cohort Study. spectra were parameterized components using SpecParam tool. We tested as well postnatal parameters while including birth weight child sex covariates. For neonates, multilevel models employed, considering different acquisitions (sleep auditory paradigm + sleep), toddlers, regression used only was available. found longer associated with a steeper frequencies Effect especially strong ( β = 0.45, p 0.004), it remained nearly statistically significant 0.061). quadratic association beta center frequency (12.5–30 Hz) found. overall higher females compared males. Offset (calculated curve at 2.5 theta had negative but not Our results suggest may relatively long‐lasting effects on physiology. possible behavioral cognitive consequences these are enticing topics for future research.

Language: Английский

Citations

0
Effect of sleep deprivation on fractal and oscillatory spectral measures of the sleep EEG: a window on basic regulatory processes DOI Creative Commons
Csenge G. Horváth, Róbert Bódizs

NeuroImage, Journal Year: 2025, Volume and Issue: 314, P. 121260 - 121260

Published: May 9, 2025

Sleep is vital for sustaining life; therefore, reliable measurement of its regulatory processes significant importance in research and medicine. Here we examine the effect extended wakefulness on putative indicators fundamental sleep (spectral slope spindle frequency) proposed by Fractal Oscillatory Adjustment model regulation involving a healthy young adult sample 35-hour long deprivation protocol. Wearable headband EEG-derived results revealed that NREM electroencephalogram (EEG) spectral estimated 2-48 Hz range an accurate indicator predicted changes depth induced (steepened slopes recovery sleep) or overnight dissipation pressure (flattening during successive cycles). While baseline dynamics center frequency oscillations followed U-shaped curve, timing minimum (the presumed phase indicator) correlated with questionnaire-based chronotype metrics as predicted, different picture emerged sleep. Advanced advanced minima oscillatory frequency, reduced considerably relationship chronotype, but retained partially evolution. Overall, our study supports use EEG homeostatic marker wake-sleep regulation, addition, encourages further measure circadian rhythm, primarily focusing interaction process.

Language: Английский

Citations

0
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans DOI Creative Commons
Rashi Pant, Kabilan Pitchaimuthu, José Ossandón

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: May 16, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent, and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I 10 individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence on early visual humans. First, participants underwent MRS scanning at rest with their eyes open closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, ratio, respectively. Subsequently, EEG was recorded assess aperiodic activity (1–20 Hz) a neurophysiological measure during flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Language: Английский

Citations

0