Chemogenetic inhibition of pain-related neurons in the posterior insula cortex reduces mechanical hyperalgesia and anxiety-like behavior during acute pain DOI Creative Commons
Ilia Potapenko, Tatsuya Ishikawa, Hiroaki Okuda

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150625 - 150625

Published: Aug. 29, 2024

Pain is a complex phenomenon that involves sensory, emotional, and cognitive components. The posterior insula cortex (pIC) has been shown to integrate multisensory experience with emotional states. However, the involvement of pIC in regulation affective behavior pain remains unclear. Here, we investigate role pain-related neurons anxiety-like during acute pain. We combined chemogenetic approach targeted recombination active populations (TRAP) mice. Global inhibition attenuates chemically-induced mechanical hypersensitivity without affecting behavior. In contrast, reduces both present study provides important insights into sensory

Language: Английский

Chronic Pain and Comorbid Emotional Disorders: Neural Circuitry and Neuroimmunity Pathways DOI Open Access
M.H. Li,

Kepeng She,

Pengfei Zhu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 436 - 436

Published: Jan. 7, 2025

Chronic pain is a multidimensional experience that not only involves persistent nociception but also frequently accompanied by significant emotional disorders, such as anxiety and depression, which complicate its management amplify impact. This review provides an in-depth exploration of the neurobiological mechanisms underlying comorbidity chronic disturbances. Key areas focus include dysregulation major neurotransmitter systems (serotonin, gamma-aminobutyric acid, glutamate) resulting functional remodeling critical neural circuits implicated in processing, regulation, reward. Given contribution neuroimmune to chronicity mood we further conducted investigation into role factors, including resident immune cells, infiltrating release inflammatory mediators. discusses current therapeutic strategies, encompassing pharmacological interventions, neuromodulation, integrative approaches, emphasizes necessity targeted treatments address both components. Finally, it identifies gaps understanding outlines future research directions aimed at elucidating complex interplay between thereby laying foundation for more effective holistic treatment paradigms.

Language: Английский

Citations

3
Anterior Cingulate Cortex–Anterior Insular Cortex Circuit Mediates Hyperalgesia in Adolescent Mice Experiencing Early Life Stress DOI
Meng Li, Kefang Liu, Mingyu Xu

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: 16(5), P. 920 - 931

Published: Feb. 17, 2025

Understanding neurobiological mechanisms underlying changes in behavior and neural activity caused by early life stress (ELS) is essential for improving these adverse outcomes individuals. ELS incited exposure to maternal separation (MS) can be defined as a form of social pain, but little known about the mechanism adolescents with ELS-induced pain sensitization. Employing an MS-induced paradigm mice, we reported here that both male female MS mice aged 1-2 months exhibited mechanical thermal hyperalgesia using paw-withdrawal hot/cold plate tests. The increased high gamma (γhigh) oscillations accompanied activation parvalbumin-positive interneurons (PVINs) anterior insular cortex (AIC), not cingulate (ACC), were shown mice. Moreover, ACC-driven AIC connectivity was enhanced characterized amplified phase coherence delta (δ) theta (θ) bands escalation coupling ACC θ γ amplitude. Chemogenetic inactivation PVINs relieved altered ACC-AIC observed increase δ-θ synchronization PVIN circuit indicates this pathway therapeutic target hyperalgesia.

Language: Английский

Citations

0
Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study DOI Creative Commons

Fengfang Li,

Di Zhang,

Jun Ren

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: June 19, 2024

Abstract Objective The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It composed functionally different subdivisions and each which plays role in PTH neuropathology. Methods Ninety-four mTBI patients were included this study. Based on perfusion imaging data obtained from arterial spin labelling (ASL) magnetic resonance (MRI), study evaluated insular subregion perfusion-based functional connectivity (FC) its correlation with clinical characteristic parameters after non-headache patients. Results subregions + (mTBI PTH) mTBI-PTH without group had positive connections other nuclei adjacent discrete cortical regions. Compared group, significantly increased resting-state FC between anterior (AI) middle cingulate cortex (MCC)/Rolandic operculum (ROL), posterior (PI) supplementary motor area (SMA), decreased PI thalamus found group. Changes left insula/dorsal thalamus/MCC significant correlated characteristics. Conclusions Our findings provide new ASL-based evidence for changes association features, revealing possibility potential neuroplasticity PTH. These may contribute early diagnosis disease follow-up progression.

Language: Английский

Citations

3
Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI DOI Creative Commons
Xiaoqing Zhou, Yuanyuan Jiang, L Gómez-Cid

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Despite extensive functional mapping studies using rodent magnetic resonance imaging (fMRI), interpreting the fMRI signals in relation to their neuronal origins remains challenging due hemodynamic nature of response. Ultra high-resolution fMRI, beyond merely enhancing spatial specificity, has revealed vessel-specific responses, highlighting distinct contributions intracortical arterioles and venules signals. This 'single-vessel' approach shifts paradigm enabling its integration with other neuroimaging modalities investigate neuro-glio-vascular (NGV) signaling underlying a variety brain dynamics. Here, we review emerging trend combining multimodal opto/chemogenetic neuromodulation genetically encoded biosensors for cellular circuit-specific recording, offering unprecedented opportunities cross-scale dynamic models.

Language: Английский

Citations

0
Biochemical strategies for opioid-sparing pain management in the operating room DOI
Fatemeh Hosseinzadeh, Alireza Nourazarian

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101927 - 101927

Published: Jan. 25, 2025

Language: Английский

Citations

0
Chemogenetic inhibition of pain-related neurons in the posterior insula cortex reduces mechanical hyperalgesia and anxiety-like behavior during acute pain DOI Creative Commons
Ilia Potapenko, Tatsuya Ishikawa, Hiroaki Okuda

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150625 - 150625

Published: Aug. 29, 2024

Pain is a complex phenomenon that involves sensory, emotional, and cognitive components. The posterior insula cortex (pIC) has been shown to integrate multisensory experience with emotional states. However, the involvement of pIC in regulation affective behavior pain remains unclear. Here, we investigate role pain-related neurons anxiety-like during acute pain. We combined chemogenetic approach targeted recombination active populations (TRAP) mice. Global inhibition attenuates chemically-induced mechanical hypersensitivity without affecting behavior. In contrast, reduces both present study provides important insights into sensory

Language: Английский

Citations

0