Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(6), P. 2437 - 2458

Published: Feb. 8, 2023

Language: Английский

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Understanding light pollution: Recent advances on its health threats and regulations

Journal of Environmental Sciences, Journal Year: 2022, Volume and Issue: 127, P. 589 - 602

Published: June 18, 2022

Language: Английский

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Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2488 - 2488

Published: Sept. 7, 2023

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated the pathogenesis various brain diseases, including neurodegenerative disorders, stroke, psychiatric illnesses. This review paper provides comprehensive overview intricate relationship between disease, focusing on underlying pathological mechanisms exploring potential therapeutic opportunities. The covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, dynamics, calcium dysregulation, reactive oxygen species generation context disease. Additionally, it discusses emerging strategies targeting dysfunction, protective agents, metabolic modulators, gene therapy approaches. By critically analysing existing literature recent advancements, this aims to enhance our understanding multifaceted disease shed light novel interventions.

Language: Английский

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Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5541 - 5571

Published: Jan. 11, 2024

Language: Английский

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A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1083 - 1083

Published: May 13, 2024

Welcome to

Language: Английский

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Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases

Biomolecules, Journal Year: 2020, Volume and Issue: 10(8), P. 1158 - 1158

Published: Aug. 7, 2020

Neurodegenerative diseases are the second most common cause of death and characterized by progressive impairments in movement or mental functioning central peripheral nervous system. The prevention neurodegenerative disorders has become an emerging public health challenge for our society. Melatonin, a pineal hormone, various physiological functions brain, including regulating circadian rhythms, clearing free radicals, inhibiting biomolecular oxidation, suppressing neuroinflammation. Cumulative evidence indicates that melatonin wide range neuroprotective roles pathophysiological mechanisms signaling pathways. Moreover, levels decreased patients with diseases. In this review, we summarize current knowledge on regulation, molecular biological such as Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, vascular dementia multiple sclerosis. We also discuss clinical application disorders. This information will lead to better understanding regulation brain provide therapeutic options treatment

Language: Английский

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Study on metabolic variation in whole grains of four proso millet varieties reveals metabolites important for antioxidant properties and quality traits

Food Chemistry, Journal Year: 2021, Volume and Issue: 357, P. 129791 - 129791

Published: April 20, 2021

Language: Английский

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Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

Inflammopharmacology, Journal Year: 2022, Volume and Issue: 30(5), P. 1569 - 1596

Published: June 5, 2022

Language: Английский

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Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression

Neurochemical Research, Journal Year: 2022, Volume and Issue: 47(10), P. 2909 - 2924

Published: June 11, 2022

Language: Английский

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Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease

Translational Neurodegeneration, Journal Year: 2022, Volume and Issue: 11(1)

Published: May 9, 2022

Abstract Background Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature Alzheimer’s disease (AD). Melatonin has been shown to prevent hyperphosphorylation in cellular animal models. However, molecular mechanisms by which melatonin attenuates tau-related pathologies are not fully understood. Methods Immunofluorescence, immunoblotting analysis thioflavin-S staining were employed examine effects early late treatment on pathology hTau mice, nonmutated human overexpressed mouse knockout background. High-throughput microRNA (miRNA) sequencing, quantitative RT-PCR, luciferase reporter assay performed determine mechanism. Results We found that both efficiently decreased phosphorylation soluble insoluble at sites related AD. Moreover, significantly reduced number neurofibrillary tangles (NFTs) attenuated neuronal loss cortex hippocampus. Furthermore, using miRNA microarray analysis, we miR-504-3p expression was upregulated mice. The administration mimics dramatically targeting p39, an activator well-known kinase cyclin-dependent 5 (CDK5). Compared with alone, co-treatment p39 failed reduce hyperphosphorylation. Conclusions Our results suggest for first time alleviates through upregulation p39/CDK5 axis provide novel insights into AD strategies.

Language: Английский

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