Assembly of functionally integrated human forebrain spheroids

Nature, Journal Year: 2017, Volume and Issue: 545(7652), P. 54 - 59

Published: April 25, 2017

Language: Английский

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Interneuron cell types are fit to function

Nature, Journal Year: 2014, Volume and Issue: 505(7483), P. 318 - 326

Published: Jan. 1, 2014

Language: Английский

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The GABAergic deficit hypothesis of major depressive disorder

Molecular Psychiatry, Journal Year: 2010, Volume and Issue: 16(4), P. 383 - 406

Published: Nov. 16, 2010

Language: Английский

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Hippocampal GABAergic Inhibitory Interneurons

Physiological Reviews, Journal Year: 2017, Volume and Issue: 97(4), P. 1619 - 1747

Published: Sept. 28, 2017

In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects cellular function. Here we provide an overview current state field interneuron research, focusing largely on hippocampus. We discuss recent advances related various cell types, including development maturation, expression subtype-specific voltage- ligand-gated channels, roles in network oscillations. also technological approaches that have permitted high-resolution, examination numerous neural disorders emerging therapeutic strategies ameliorate such pathophysiological conditions. The ultimate goal this review is not a touchstone for field, but help pave way future research by highlighting where gaps our knowledge exist how complete appreciation will aid strategies.

Language: Английский

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Development and Functional Diversification of Cortical Interneurons

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 294 - 313

Published: Oct. 1, 2018

Language: Английский

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Gain control by layer six in cortical circuits of vision

Nature, Journal Year: 2012, Volume and Issue: 483(7387), P. 47 - 52

Published: Feb. 21, 2012

Language: Английский

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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Pharmacological Reviews, Journal Year: 2021, Volume and Issue: 73(4), P. 1469 - 1658

Published: Oct. 1, 2021

Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels critical to brain function and centrally implicated numerous psychiatric neurologic disorders. There different classes iGluRs with a variety receptor subtypes each class that play distinct roles neuronal functions. The diversity iGluR subtypes, their unique functional properties roles, has motivated large number studies. Our understanding advanced considerably since first subunit gene was cloned 1989, research focus expanded encompass facets biology have been recently discovered exploit experimental paradigms made possible technological advances. Here, we review insights from more than 3 decades studies an emphasis on progress occurred past decade. We cover structure, function, pharmacology, neurophysiology, therapeutic implications for all assembled subunits encoded 18 genes. SIGNIFICANCE STATEMENT: Glutamate important virtually aspects either involved mediating some clinical features neurological disease or represent target treatment. Therefore, pharmacology this will advance our many at molecular, cellular, system levels provide new opportunities treat patients.

Language: Английский

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GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

Neuron, Journal Year: 2011, Volume and Issue: 70(3), P. 385 - 409

Published: May 1, 2011

Language: Английский

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GABAergic Interneurons Shape the Functional Maturation of the Cortex

Neuron, Journal Year: 2013, Volume and Issue: 77(3), P. 388 - 405

Published: Feb. 1, 2013

Language: Английский

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Role of Ion Channels and Transporters in Cell Migration

Physiological Reviews, Journal Year: 2012, Volume and Issue: 92(4), P. 1865 - 1913

Published: Oct. 1, 2012

Cell motility is central to tissue homeostasis in health and disease, there hardly any cell the body that not motile at a given point its life cycle. Important physiological processes intimately related ability of respective cells migrate include embryogenesis, immune defense, angiogenesis, wound healing. On other side, migration associated with life-threatening pathologies such as tumor metastases atherosclerosis. Research from last ∼15 years revealed ion channels transporters are indispensable components cellular apparatus. After presenting general principles by which transport proteins affect migration, we will discuss systematically role involved migration.

Language: Английский

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