Molecular Psychiatry,
Journal Year:
2022,
Volume and Issue:
28(1), P. 284 - 297
Published: Oct. 6, 2022
Abstract
Major
depressive
disorder
(MDD)
is
a
psychiatric
disease
of
still
poorly
understood
molecular
etiology.
Extensive
studies
at
different
levels
point
to
high
complexity
numerous
interrelated
pathways
as
the
underpinnings
depression.
systems
under
consideration
include
monoamines,
stress,
neurotrophins
and
neurogenesis,
excitatory
inhibitory
neurotransmission,
mitochondrial
dysfunction,
(epi)genetics,
inflammation,
opioid
system,
myelination,
gut-brain
axis,
among
others.
This
review
aims
illustrating
how
these
multiple
signaling
may
interact
provide
more
comprehensive
view
MDD’s
neurobiology.
In
particular,
considering
pattern
synaptic
activity
closest
physical
representation
mood,
emotion,
conscience
we
can
conceptualize,
each
pathway
or
system
will
be
scrutinized
for
links
neurotransmission.
Models
neurobiology
MDD
discussed
well
future
actions
improve
understanding
treatment
options.
Physiological Reviews,
Journal Year:
2017,
Volume and Issue:
97(4), P. 1619 - 1747
Published: Sept. 28, 2017
In
the
hippocampus
GABAergic
local
circuit
inhibitory
interneurons
represent
only
~10–15%
of
total
neuronal
population;
however,
their
remarkable
anatomical
and
physiological
diversity
allows
them
to
regulate
virtually
all
aspects
cellular
function.
Here
we
provide
an
overview
current
state
field
interneuron
research,
focusing
largely
on
hippocampus.
We
discuss
recent
advances
related
various
cell
types,
including
development
maturation,
expression
subtype-specific
voltage-
ligand-gated
channels,
roles
in
network
oscillations.
also
technological
approaches
that
have
permitted
high-resolution,
examination
numerous
neural
disorders
emerging
therapeutic
strategies
ameliorate
such
pathophysiological
conditions.
The
ultimate
goal
this
review
is
not
a
touchstone
for
field,
but
help
pave
way
future
research
by
highlighting
where
gaps
our
knowledge
exist
how
complete
appreciation
will
aid
strategies.
Neuron,
Journal Year:
2014,
Volume and Issue:
81(3), P. 484 - 503
Published: Feb. 1, 2014
Major
depression
is
the
commonest
psychiatric
disorder
and
in
U.S.
has
greatest
impact
of
all
biomedical
diseases
on
disability.
Here
we
review
evidence
genetic
contribution
to
disease
susceptibility
current
state
molecular
approaches.
Genome-wide
association
linkage
results
provide
constraints
allele
frequencies
effect
sizes
loci,
which
use
interpret
voluminous
candidate
gene
literature.
We
consider
for
heterogeneity
likelihood
that
subtypes
exist
represent
more
genetically
homogenous
conditions
than
have
hitherto
been
analyzed.
