Interplay of Hippocampus and Prefrontal Cortex in Memory

Current Biology, Journal Year: 2013, Volume and Issue: 23(17), P. R764 - R773

Published: Sept. 1, 2013

Language: Английский

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Memory engrams: Recalling the past and imagining the future

Science, Journal Year: 2020, Volume and Issue: 367(6473)

Published: Jan. 3, 2020

In 1904, Richard Semon introduced the term "engram" to describe neural substrate for storing memories. An experience, proposed, activates a subset of cells that undergo off-line, persistent chemical and/or physical changes become an engram. Subsequent reactivation this engram induces memory retrieval. Although Semon's contributions were largely ignored in his lifetime, new technologies allow researchers image and manipulate brain at level individual neurons has reinvigorated research. We review recent progress studying engrams, including evaluation evidence existence importance intrinsic excitability synaptic plasticity lifetime Together, these findings are beginning define as basic unit memory.

Language: Английский

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How schema and novelty augment memory formation

Trends in Neurosciences, Journal Year: 2012, Volume and Issue: 35(4), P. 211 - 219

Published: March 6, 2012

Language: Английский

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The Restless Engram: Consolidations Never End

Annual Review of Neuroscience, Journal Year: 2012, Volume and Issue: 35(1), P. 227 - 247

Published: May 20, 2012

Memory consolidation is the hypothetical process in which an item memory transformed into a long-term form. It commonly addressed at two complementary levels of description and analysis: cellular/synaptic level (synaptic consolidation) brain systems (systems consolidation). This article focuses on selected recent advances research, including reconsolidation items, mechanisms transformation content cue-dependency items over time, as well role rest sleep consolidating shaping memories. Taken together, picture that emerges dynamic engrams are formed, modified, remodified time by using synaptic subroutines. implies that, contrary to interpretations have dominated neuroscience for while, but similar long-standing cognitive concepts, least some may never really come end.

Language: Английский

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Questions and controversies in the study of time-varying functional connectivity in resting fMRI

Network Neuroscience, Journal Year: 2019, Volume and Issue: 4(1), P. 30 - 69

Published: Dec. 16, 2019

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge the spatiotemporal organization these interactions critical for establishing solid understanding brain's functional architecture and relationship between neural dynamics cognition in health disease. possibility studying through careful analysis neuroimaging data has catalyzed substantial interest methods that estimate time-resolved fluctuations connectivity (often referred to as "dynamic" or time-varying connectivity; TVFC). At same time, debates have emerged regarding application TVFC analyses resting fMRI data, about statistical validity, physiological origins, cognitive behavioral relevance TVFC. These other unresolved issues complicate interpretation findings limit insights can be gained from this promising new research area. This article brings together scientists with variety perspectives on review current literature light issues. We introduce core concepts, define key terms, summarize controversies open questions, present forward-looking perspective how rigorously productively applied investigate wide range questions systems neuroscience.

Language: Английский

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High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research

Progress in Neurobiology, Journal Year: 2012, Volume and Issue: 98(3), P. 279 - 301

Published: June 27, 2012

Language: Английский

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Fear Memory

Physiological Reviews, Journal Year: 2016, Volume and Issue: 96(2), P. 695 - 750

Published: March 17, 2016

Fear memory is the best-studied form of memory. It was thoroughly investigated in past 60 years mostly using two classical conditioning procedures (contextual fear and to a tone) one instrumental procedure (one-trial inhibitory avoidance). formed hippocampus avoidance), basolateral amygdala (inhibitory lateral (conditioning tone). The circuitry involves, addition, pre- infralimbic ventromedial prefrontal cortex, central subnuclei, dentate gyrus. learning models, notably avoidance, have also been very useful for analysis biochemical mechanisms consolidation as whole. These studies capitalized on vitro observations long-term potentiation other kinds plasticity. effect large number drugs has intensively studied, often prelude investigation effects anxiety. extinction involves an extent reversal flow information mentioned structures used therapy posttraumatic stress disorder memories general.

Language: Английский

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Memory integration: neural mechanisms and implications for behavior

Current Opinion in Behavioral Sciences, Journal Year: 2014, Volume and Issue: 1, P. 1 - 8

Published: Aug. 20, 2014

Language: Английский

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Hippocampal Representation of Related and Opposing Memories Develop within Distinct, Hierarchically Organized Neural Schemas

Neuron, Journal Year: 2014, Volume and Issue: 83(1), P. 202 - 215

Published: June 5, 2014

Language: Английский

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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

Cell, Journal Year: 2014, Volume and Issue: 156(1-2), P. 261 - 276

Published: Jan. 1, 2014

Language: Английский

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