Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(19), P. 7120 - 7125

Published: April 22, 2014

Significance We have discovered a critical role for ten-eleven translocation 3-mediated hydroxylation of 5-methycytosine in the adult prefrontal cortex mediating rapid behavioral adaptation. 5-hydroxymethylcytosine (5-hmC) is highly dynamic response to fear extinction training, and rather than simply reflecting functional intermediary active DNA demethylation, learning-induced intergenic accumulation 5-hmC creates an epigenetic state that promotes experience-dependent gene expression

Language: Английский

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Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(4), P. 536 - 544

Published: March 16, 2015

Language: Английский

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Epigenetic Alterations in Alzheimer’s Disease

Frontiers in Behavioral Neuroscience, Journal Year: 2015, Volume and Issue: 9

Published: Dec. 17, 2015

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses asymptomatically during decades before being belatedly diagnosed when therapeutic strategies have become unviable. Although several genetic alterations been associated with AD, vast majority AD cases do not show strong underpinnings and are thus considered a consequence non-genetic factors. Epigenetic mechanisms allow for integration long-lasting inputs on specific backgrounds, recently, growing number epigenetic described. For instance, an accumulation dysregulated aging, predominant risk factor might facilitate onset disease. Likewise, mutations enzymes machinery neurodegenerative processes that altered such as impaired learning memory formation. Genome-wide locus-specific also reported, epigenetically genes validated by independent groups. From these studies, picture emerges DNA hypermethylation histone deacetylation, suggesting general repressed chromatin state reduced plasticity AD. Here we review recent findings discuss technical methodological considerations imperative their correct interpretation. We pay particular focus potential implementations theoretical frameworks expect will help to better direct future studies aimed unravel participation

Language: Английский

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An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

Neuron, Journal Year: 2017, Volume and Issue: 94(2), P. 337 - 346.e6

Published: April 1, 2017

Language: Английский

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The landscape of DNA methylation amid a perfect storm of autism aetiologies

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(7), P. 411 - 423

Published: May 6, 2016

Language: Английский

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