Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(9), P. 1117 - 1117
Published: Sept. 4, 2024
This
review
deals
with
the
functional
characteristics
and
biological
roles
of
enzymes
participating
in
DNA
methylation
demethylation
as
key
factors
epigenetic
regulation
gene
expression.
The
set
that
carry
out
such
processes
human
cells
is
limited
to
representatives
two
families,
namely
DNMT
(DNA
methyltransferases)
TET
dioxygenases).
presents
detailed
information
known
today
about
each
functionally
important
member
these
families
describes
catalytic
activity
mammalian
body
while
also
providing
examples
dysregulation
expression
and/or
conjunction
development
some
disorders,
including
cancers,
neurodegenerative
diseases,
developmental
pathologies.
By
combining
up-to-date
on
dysfunction
various
control
"methylome"
body,
we
hope
not
only
draw
attention
importance
maintenance
a
required
level
(ensuring
normal
functioning
entire
body)
but
help
identify
new
targets
for
directed
over
implement
balance
between
demethylation.
Annual Review of Cell and Developmental Biology,
Journal Year:
2018,
Volume and Issue:
34(1), P. 495 - 521
Published: July 25, 2018
After
an
injury
in
the
adult
mammalian
central
nervous
system
(CNS),
lesioned
axons
fail
to
regenerate.
This
failure
regenerate
contrasts
with
axons'
remarkable
potential
grow
during
embryonic
development
and
after
peripheral
(PNS).
Several
intracellular
mechanisms-including
cytoskeletal
dynamics,
axonal
transport
trafficking,
signaling
transcription
of
regenerative
programs,
epigenetic
modifications-control
axon
regeneration.
In
this
review,
we
describe
how
manipulation
intrinsic
mechanisms
elicits
a
response
different
organisms
strategies
are
implemented
form
basis
future
treatment
CNS
injury.
Annual Review of Vision Science,
Journal Year:
2020,
Volume and Issue:
6(1), P. 195 - 213
Published: Sept. 15, 2020
The
damage
or
loss
of
retinal
ganglion
cells
(RGCs)
and
their
axons
accounts
for
the
visual
functional
defects
observed
after
traumatic
injury,
in
degenerative
diseases
such
as
glaucoma,
compressive
optic
neuropathies
from
glioma.
By
using
nerve
crush
injury
models,
recent
studies
have
revealed
cellular
molecular
logic
behind
regenerative
failure
injured
RGC
adult
mammals
suggested
several
strategies
with
translational
potential.
This
review
summarizes
these
findings
discusses
challenges
developing
clinically
applicable
neural
repair
strategies.
Materials Today,
Journal Year:
2021,
Volume and Issue:
51, P. 165 - 187
Published: Oct. 12, 2021
Neuronal
microenvironment
imbalance
is
associated
with
successive
and
irreversible
pathophysiological
changes
insufficient
functional
restoration
after
peripheral
nerve
injury.
Conventional
neural-supporting
scaffolds
result
in
unsatisfactory
curative
effects
due
to
lack
of
biomimetic
nanotechnology
designs
biochemical
or
physicochemical
modifications.
Consequently,
they
fail
rational
facile
remodeling
the
imbalanced
growth
microenvironment,
cannot
recover
neural
structure
function.
In
recent
years,
increasing
knowledge
neuronal
injury-associated
a
number
novel
strategies
are
applied
enhancing
natures
nanomaterial-based
for
tissue
engineering.
These
nanoscale
can
trigger
factor
secretion
aggregation
through
surface
modification,
regulate
ATP
synthesis
hydrolysis,
switch
between
oxidation
reduction
states,
activate
ion
channels
stimulate
electrical
signals
under
certain
biophysical
cues.
determine
cell
fate
by
modulating
their
viability,
development
cycles
during
regeneration
process.
this
review,
we
systematically
summarize
studies
on
scaffold
design
nanomaterials,
basic
topological,
physical
properties,
nanotechnology-based
balanced
nutritional
regarding
four
key
factors,
including
immune
response,
intraneural
vascularization,
bioenergetic
metabolism
bioelectrical
conduction
order
provide
ideas
inspiration
nanomedicine-based
therapy.
