Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI

Neural Plasticity, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 14

Published: Aug. 19, 2021

Acupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation. Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic resonance imaging (MRI), noninvasive, high anatomical resolution technique, has been employed to investigate neuroplasticity on acupuncture patients from system level. However, there no review the mechanism of based MRI. Therefore, we aim summarize current evidence about aspect and provide useful information future research. After searching PubMed, Web Science, Embase databases, 24 human five animal studies were identified. This focuses possible mechanisms underlying therapy treating by regulating brain plasticity. We found that reorganizes not only motor-related network, including primary motor cortex (M1), premotor cortex, supplementary (SMA), frontoparietal network (LFPN RFPN), sensorimotor (SMN), well default mode (aDMN pDMN), but also language-related areas inferior frontal gyrus frontal, temporal, parietal, occipital lobes, cognition-related regions. In addition, can modulate function structural plasticity post-stroke, which may be linked effect acupuncture.

Language: Английский

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Type-B monoamine oxidase inhibitors in neurological diseases

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(1), P. 16 - 21

Published: May 25, 2023

Type-B monoamine oxidase inhibitors, encompassing selegiline, rasagiline, and safinamide, are available to treat Parkinson's disease. These drugs ameliorate motor symptoms improve fluctuation in the advanced stages of There is also evidence supporting benefit type-B inhibitors on non-motor disease, such as mood deflection, cognitive impairment, sleep disturbances, fatigue. Preclinical studies indicate that hold a strong neuroprotective potential disease other neurodegenerative diseases for reducing oxidative stress stimulating production release neurotrophic factors, particularly glial cell line-derived factor, which support dopaminergic neurons. Besides, safinamide may interfere with mechanisms, counteracting excessive glutamate overdrive basal ganglia circuit death from excitotoxicity. Due dual mechanism action, new generation including gaining interest neurological pathologies, many preclinical now available. The fields application concern epilepsy, Duchenne muscular dystrophy, multiple sclerosis, above all, ischemic brain injury. purpose this review investigate clinical pharmacology beyond, focusing possible future therapeutic applications.

Language: Английский

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Evidence of rTMS for Motor or Cognitive Stroke Recovery: Hype or Hope?

Stroke, Journal Year: 2023, Volume and Issue: 54(10), P. 2500 - 2511

Published: Sept. 25, 2023

Evidence of efficacy repetitive transcranial magnetic stimulation (rTMS) for stroke recovery is hampered by an unexplained variability reported effect sizes and insufficient understanding mechanisms action. We aimed to (1) briefly summarize evidence efficacy, (2) identify critical factors explain the variation in effects, (3) provide mechanism-based recommendations future trials.We performed a systematic review literature according Cochrane PRISMA Protocols. included trials with ≥10 patients per treatment group. classified outcome measures International Classification Functioning, Disability, Health. Meta-analysis was done when at least 3 were on same construct. In case significant summary heterogeneity, we used sensitivity analyses test correlations differences between found individual possible modifiers such as patient-, stimulation-, trial characteristics.We 57 articles (N=2595). Funnel plots showed no publication bias. level body function (upper limb synergies, muscle strength, language functioning, global cognitive visual/spatial inattention) within or beyond months after stroke. also activities. subgroup any tested modifier.Repetitive holds potential benefit range motor outcomes stroke, but challenged heterogeneity across many small sampled trials. propose large collection patient data baseline severity brain network integrity sufficiently powered analyses, well protocolized time-locked training target behavior. Additional neurophysiological biomechanical may help identifying biomarkers efficacy.URL: https://www.gov; Unique identifier: CRD42022300330.

Language: Английский

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PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke

Neuron, Journal Year: 2023, Volume and Issue: 111(19), P. 2995 - 3010.e9

Published: July 24, 2023

Language: Английский

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Social neuroscience: undoing the schism between neurology and psychiatry

Social Neuroscience, Journal Year: 2016, Volume and Issue: 13(1), P. 1 - 39

Published: Oct. 6, 2016

Multiple disorders once jointly conceived as "nervous diseases" became segregated by the distinct institutional traditions forged in neurology and psychiatry. As a result, each field specialized study treatment of subset such conditions. Here we propose new avenues for interdisciplinary interaction through triangulation both fields with social neuroscience. To this end, review evidence from five relevant domains (facial emotion recognition, empathy, theory mind, moral cognition, context assessment), highlighting their common disturbances across neurological psychiatric conditions discussing multiple pathophysiological mechanisms. Our proposal is anchored multidimensional evidence, including behavioral, neurocognitive, genetic findings. From clinical perspective, work paves way dimensional transdiagnostic approaches, pharmacological treatments, educational innovations rooted combined neuropsychiatric training. Research-wise, it fosters models brain novel platform to explore interplay cognitive functions. Finally, identify challenges synergistic framework.

Language: Английский

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