A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Neuron, Journal Year: 2018, Volume and Issue: 101(1), P. 133 - 151.e7

Published: Nov. 29, 2018

Language: Английский

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Endogenous and Exogenous Opioids in Pain

Annual Review of Neuroscience, Journal Year: 2018, Volume and Issue: 41(1), P. 453 - 473

Published: May 31, 2018

Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse overdose. These compounds act on endogenous opioid system, which comprises four G protein-coupled receptors (mu, delta, kappa, nociceptin) major peptide families (β-endorphin, enkephalins, dynorphins, nociceptin/orphanin FQ). In this review, we first describe functional organization pharmacology system. We then summarize current knowledge signaling mechanisms by opioids regulate neuronal function neurotransmission. Finally, discuss loci action along peripheral central pain pathways, emphasizing pain-relieving properties against affective dimension experience.

Language: Английский

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Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

Neuron, Journal Year: 2017, Volume and Issue: 93(3), P. 509 - 521.e3

Published: Jan. 26, 2017

Language: Английский

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Opioid receptors: drivers to addiction?

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(8), P. 499 - 514

Published: June 22, 2018

Language: Английский

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Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(2), P. 611 - 681

Published: Sept. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Language: Английский

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Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

eLife, Journal Year: 2017, Volume and Issue: 6

Published: July 14, 2017

Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-like and aversive behavior. While some information is known about the afferent circuitry that endogenously drives this neural behavior, downstream receptors anatomical projections mediate these acute risk behavioral states via LC-NE system remain unresolved. Here we use a combination retrograde tracing, fast-scan cyclic voltammetry, electrophysiology, in vivo optogenetics with localized pharmacology to identify substrates increased mice. We demonstrate photostimulation fibers BLA evokes norepinephrine release basolateral amygdala (BLA), alters neuronal activity, conditions aversion, increases Additionally, report β-adrenergic phenotype NE BLA. These studies begin illustrate how complex efferent selectively mediates behavior through distinct receptor projection-selective mechanisms.

Language: Английский

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Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

Pharmacological Reviews, Journal Year: 2016, Volume and Issue: 68(2), P. 419 - 457

Published: March 8, 2016

The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently discovered member of family and, together with its endogenous ligand, N/OFQ, make up fourth members and family. Because more recent discovery, an understanding cellular behavioral actions induced by activation are less well developed than for other All these factors important because has a clear modulatory role on mu receptor-mediated thereby affects analgesia, tolerance development, reward. In addition to actions, effects motor function physiologic processes. This review discusses how pharmacology intersects, contrasts, interacts in terms tertiary structure mechanism activation; location receptors central nervous system; mechanisms desensitization downregulation; actions; intracellular signal transduction pathways; respect tolerance, dependence, followed discussion agonists antagonists that have contributed our current knowledge. highly expressed brain spinal cord sometimes synergizes opposes them, context interactions will be crucial development novel therapeutics engage receptor.

Language: Английский

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A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell

Neuron, Journal Year: 2019, Volume and Issue: 102(3), P. 529 - 552

Published: May 1, 2019

Language: Английский

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Reward and Aversion

Annual Review of Neuroscience, Journal Year: 2016, Volume and Issue: 39(1), P. 297 - 324

Published: May 5, 2016

To benefit from opportunities and cope with challenges in the environment, animals must adapt their behavior to acquire rewards avoid punishments. Maladaptive changes neuromodulatory systems neural circuits for reward aversion can lead manifestation of several prominent psychiatric disorders including addiction depression. Recent progress is pushing boundaries knowledge on two major fronts research aversion: First, new layers complexity have been reported functions dopamine (DA) serotonin (5-HT) aversion. Second, specific circuit components pathways that encode begun be identified. This review aims outline historic perspectives insights into DA 5-HT coding distinct rewards. It also highlights recent advances studies enabled by technologies, such as cell-type-specific electrophysiology tracing, optogenetics-based behavioral manipulation. may provide guidance developing novel treatment strategies neuropsychiatric diseases related malfunction system.

Language: Английский

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Neural Circuit Motifs in Valence Processing

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 436 - 452

Published: Oct. 1, 2018

Language: Английский

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