Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states DOI Creative Commons
Yoav Livneh, Mark L. Andermann

Neuron, Journal Year: 2021, Volume and Issue: 109(22), P. 3576 - 3593

Published: Sept. 27, 2021

Language: Английский

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments DOI Creative Commons
Ronald S. Duman, Gerard Sanacora, John H. Krystal

et al.

Neuron, Journal Year: 2019, Volume and Issue: 102(1), P. 75 - 90

Published: April 1, 2019

Language: Английский

Citations

785
Embracing diversity in the 5-HT neuronal system DOI
Benjamin W. Okaty, Kathryn G. Commons, Susan M. Dymecki

et al.

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(7), P. 397 - 424

Published: April 4, 2019

Language: Английский

Citations

258
Neural mechanisms of social homeostasis DOI Creative Commons

Gillian A. Matthews,

Kay M. Tye

Annals of the New York Academy of Sciences, Journal Year: 2019, Volume and Issue: 1457(1), P. 5 - 25

Published: March 15, 2019

Social connections are vital to survival throughout the animal kingdom and dynamic across life span. There debilitating consequences of social isolation loneliness, support is increasingly a primary consideration in health care, disease prevention, recovery. Considering connection as an "innate need," it hypothesized that evolutionarily conserved neural systems underlie maintenance connections: alerting individual their absence coordinating effector mechanisms restore contact. This reminiscent homeostatic system designed maintain connection. Here, we explore identity regulating "social homeostasis." We review findings from rodent studies evaluating rapid response deficit (in form acute isolation) propose parallel, overlapping circuits engaged adapt vulnerabilities By considering other needs, such energy fluid balance, discuss potential attributes circuitry. reason uncovering these circuits/mechanisms will facilitate our understanding how loneliness perpetuates long-term states, which speculate may result sustained recruitment circuits.

Language: Английский

Citations

214
Viewpoints: Approaches to defining and investigating fear DOI
Dean Mobbs, Ralph Adolphs, Michael S. Fanselow

et al.

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(8), P. 1205 - 1216

Published: July 22, 2019

Language: Английский

Citations

180
The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2545 - 2570

Published: May 27, 2022

Language: Английский

Citations

142
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior DOI
Guangwei Zhang, Li Shen, Can Tao

et al.

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(4), P. 516 - 528

Published: Feb. 1, 2021

Language: Английский

Citations

120
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation DOI Creative Commons
Christopher R. Lee, Alon Chen, Kay M. Tye

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1500 - 1516

Published: March 1, 2021

Social homeostasis is the ability of individuals to detect quantity and quality social contact, compare it an established set-point in a command center, adjust effort expended seek optimal contact expressed via effector system. becomes positive or negative valence stimulus when deficient excess, respectively. Chronic deficits lead adaptations such that reintroduction previous optimum experienced as surplus. Here, we build upon models for include lasting changes environmental conditions, with chronic isolation.

Language: Английский

Citations

106
Common and stimulus-type-specific brain representations of negative affect DOI
Marta Čeko, Philip A. Kragel, Choong‐Wan Woo

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(6), P. 760 - 770

Published: May 30, 2022

Language: Английский

Citations

84
Neural Circuits for Emotion DOI Creative Commons
Meryl Malézieux, Alexandra S. Klein, Nadine Gogolla

et al.

Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 211 - 231

Published: March 14, 2023

Emotions are fundamental to our experience and behavior, affecting motivating all aspects of lives. Scientists various disciplines have been fascinated by emotions for centuries, yet even today vigorous debates abound about how define best study their neural underpinnings. Defining from an evolutionary perspective acknowledging important functional roles in supporting survival allows the emotion states diverse species. This approach enables taking advantage modern tools behavioral, systems, circuit neurosciences, allowing precise dissection mechanisms behavior underlying processes model organisms. Here we review findings processing across species try identify points convergence as well next steps pursuit understanding emerge activity.

Language: Английский

Citations

64
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition DOI
Mala Ananth, Prithviraj Rajebhosale, Ronald Kim

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(4), P. 233 - 251

Published: Feb. 23, 2023

Language: Английский

Citations

62