Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

Molecular Psychiatry, Journal Year: 2019, Volume and Issue: 25(12), P. 3241 - 3255

Published: Aug. 28, 2019

Deficits in decoding rewarding (and aversive) signals are present several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying underlying neural circuits detail. One key regions reward circuit is nucleus accumbens (NAc). The classical view on field postulates that NAc dopamine receptor D1-expressing medium spiny neurons (D1-MSNs) convey signals, while D2-expressing MSNs (D2-MSNs) encode aversion. Here, we show both MSN subpopulations can drive aversion, depending their neuronal stimulation pattern. Brief D1- or D2-MSN optogenetic elicited positive reinforcement enhanced cocaine conditioning. Conversely, prolonged activation induced case D2-MSNs, decreased was associated with increased ventral tegmenta area (VTA) dopaminergic tone either directly (for D1-MSNs) indirectly via pallidum (VP) D2-MSNs). Importantly, subpopulation remarkably distinct electrophysiological effects these target regions. We further blocking κ-opioid receptors VTA (but not VP) abolishes behavioral by D1-MSN stimulation. In turn, δ-opioid VP VTA) blocks Our findings demonstrate D2-MSNs bidirectionally control explaining existence controversial studies field, highlights proposed striatal functional opposition needs to be reconsidered.

Language: Английский

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Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression

Biological Psychiatry, Journal Year: 2016, Volume and Issue: 81(8), P. 645 - 653

Published: Sept. 16, 2016

Language: Английский

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Homeostasis Meets Motivation in the Battle to Control Food Intake

Journal of Neuroscience, Journal Year: 2016, Volume and Issue: 36(45), P. 11469 - 11481

Published: Nov. 9, 2016

Signals of energy homeostasis interact closely with neural circuits motivation to control food intake. An emerging hypothesis is that the transition maladaptive feeding behavior seen in eating disorders or obesity may arise from dysregulation these interactions. Focusing on key brain regions involved intake (ventral tegmental area, striatum, hypothalamus, and thalamus), we describe how activity specific cell types embedded within can influence distinct components motivated behavior. We review signals behavioral output present evidence experience-dependent adaptations represent cellular correlates impaired control. Future research into mechanisms restore balance between inspire new treatment options for obesity.

Language: Английский

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Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System

Neuron, Journal Year: 2019, Volume and Issue: 102(3), P. 564 - 573.e6

Published: March 13, 2019

Language: Английский

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Affective valence in the brain: modules or modes?

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(4), P. 225 - 234

Published: Feb. 4, 2019

Language: Английский

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Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry

Science Advances, Journal Year: 2019, Volume and Issue: 5(3)

Published: March 1, 2019

Wireless, battery-free optoelectronic systems enable localized tissue oximetry in tether-free, awake animal models.

Language: Английский

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Brain circuits for pain and its treatment

Science Translational Medicine, Journal Year: 2021, Volume and Issue: 13(619)

Published: Nov. 10, 2021

Understanding the organization of brain’s pain circuits is critical for developing effective treatments patients suffering from chronic pain.

Language: Английский

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Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(12), P. 1757 - 1771

Published: Oct. 18, 2021

Language: Английский

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Neural circuits of social behaviors: Innate yet flexible

Neuron, Journal Year: 2021, Volume and Issue: 109(10), P. 1600 - 1620

Published: March 11, 2021

Language: Английский

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The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network

Frontiers in Behavioral Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Feb. 24, 2021

The brain anxiety network is composed of a number interconnected cortical regions that detect threats and execute appropriate defensive responses via projections to the shell nucleus accumbens (NAcSh), dorsolateral region bed stria terminalis (BSTDL) lateral central amygdala (CeL). paraventricular thalamus (PVT) anatomically positioned integrate threat- arousal-related signals from cortex hypothalamus then relay these neural circuits in NAcSh, BSTDL, CeL mediate responses. This review describes anatomical connections PVT support view may be critical node network. Experimental findings are reviewed showing arousal peptides orexins (hypocretins) act at promote avoidance potential especially following exposure rats single episode footshocks. Recent experimental discussed which show neurons provide divergent subcortical behaviors projection NAcSh for enhanced social displayed exposed A theoretical model proposed how integrates hypothalamic modulate behavioral associated with other challenging situations.

Language: Английский

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