An Ultrasensitive, Visco‐Poroelastic Artificial Mechanotransducer Skin Inspired by Piezo2 Protein in Mammalian Merkel Cells DOI
Ming Jin,

Sangsik Park,

Young‐Hoon Lee

et al.

Advanced Materials, Journal Year: 2017, Volume and Issue: 29(13)

Published: Feb. 10, 2017

An artificial ionic mechanotransducer skin with an unprecedented sensitivity over a wide spectrum of pressure by fabricating visco-poroelastic nanochannels and microstructured features, directly mimicking the physiological tactile sensing mechanism Piezo2 protein is demonstrated. This capability enables voice identification, health monitoring, daily measurements, even measurements heavy weight beyond capabilities human skin. As service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher responsible content functionality any Any queries content) directed corresponding author article.

Language: Английский

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation DOI
Felipe A. Pinho‐Ribeiro, Waldiceu A. Verri, Isaac M. Chiu

et al.

Trends in Immunology, Journal Year: 2016, Volume and Issue: 38(1), P. 5 - 19

Published: Oct. 25, 2016

Language: Английский

Citations

816
Structure of the mechanically activated ion channel Piezo1 DOI
Kei Saotome, Swetha E. Murthy, Jennifer M. Kefauver

et al.

Nature, Journal Year: 2017, Volume and Issue: 554(7693), P. 481 - 486

Published: Dec. 20, 2017

Language: Английский

Citations

507
Structure and mechanogating mechanism of the Piezo1 channel DOI
Qiancheng Zhao, Heng Zhou, Shaopeng Chi

et al.

Nature, Journal Year: 2018, Volume and Issue: 554(7693), P. 487 - 492

Published: Jan. 22, 2018

Language: Английский

Citations

482
Piezos thrive under pressure: mechanically activated ion channels in health and disease DOI
Swetha E. Murthy, Adrienne E. Dubin, Ardem Patapoutian

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 771 - 783

Published: Oct. 4, 2017

Language: Английский

Citations

478
Discoveries in structure and physiology of mechanically activated ion channels DOI
Jennifer M. Kefauver, Andrew B. Ward, Ardem Patapoutian

et al.

Nature, Journal Year: 2020, Volume and Issue: 587(7835), P. 567 - 576

Published: Nov. 25, 2020

Language: Английский

Citations

451
Piezo1 Channels Are Inherently Mechanosensitive DOI Creative Commons
Ruhma Syeda,

Maria Florendo,

Charles D. Cox

et al.

Cell Reports, Journal Year: 2016, Volume and Issue: 17(7), P. 1739 - 1746

Published: Nov. 1, 2016

Language: Английский

Citations

449
Enantiomer-dependent immunological response to chiral nanoparticles DOI
Liguang Xu, Xiuxiu Wang, Weiwei Wang

et al.

Nature, Journal Year: 2022, Volume and Issue: 601(7893), P. 366 - 373

Published: Jan. 19, 2022

Language: Английский

Citations

434
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction DOI
Sirio Dupont

Experimental Cell Research, Journal Year: 2015, Volume and Issue: 343(1), P. 42 - 53

Published: Nov. 4, 2015

Language: Английский

Citations

409
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea DOI

Keiko Nonomura,

Seung-Hyun Woo,

Rui B. Chang

et al.

Nature, Journal Year: 2016, Volume and Issue: 541(7636), P. 176 - 181

Published: Dec. 20, 2016

Language: Английский

Citations

370
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies? DOI Creative Commons
Natalia Prevarskaya, Roman Skryma, Yaroslav Shuba

et al.

Physiological Reviews, Journal Year: 2018, Volume and Issue: 98(2), P. 559 - 621

Published: Feb. 7, 2018

Genomic instability is a primary cause and fundamental feature of human cancer. However, all cancer cell genotypes generally translate into several common pathophysiological features, often referred to as hallmarks. Although nowadays the catalog hallmarks quite broad, most obvious them are 1) uncontrolled proliferation, 2) resistance programmed death (apoptosis), 3) tissue invasion metastasis, 4) sustained angiogenesis. Among genes affected by cancer, those encoding ion channels present. Membrane proteins responsible for signaling within among cells, coupling extracellular events with intracellular responses, maintaining ionic homeostasis contribute various extents features each hallmark. Moreover, tight association these channel dysfunction gives good reason classify special type channelopathies, namely oncochannelopathies. relation differs from classical definition disease states causally linked inherited mutations that alter channel's biophysical properties, in broader context state, which pathogenesis essentially contribute, such classification seems absolutely appropriate. In this review authors provide arguments substantiate point view.

Language: Английский

Citations

369