Role of Extracellular Matrix in Development and Cancer Progression

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(10), P. 3028 - 3028

Published: Oct. 4, 2018

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. ECM is highly dynamic as it constantly deposited, remodelled, degraded during development until maturity to maintain tissue homeostasis. ECM’s composition organization are spatiotemporally regulated control behaviour differentiation, but dysregulation dynamics leads the diseases such cancer. chemical cues presented by have been appreciated key drivers for both cancer progression. However, mechanical forces present due largely ignored recently recognized play critical roles in disease progression malignant behaviour. Here, we review ways which microenvironment regulation phenotype stages human

Language: Английский

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E-cadherin in contact inhibition and cancer

Oncogene, Journal Year: 2018, Volume and Issue: 37(35), P. 4769 - 4780

Published: May 17, 2018

Language: Английский

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Cell Adhesion by Integrins

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1655 - 1699

Published: July 17, 2019

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and extracellular matrix. In addition to anchorage of matrix, these have critical functions in intracellular signaling, but also taking center stage many physiological pathological conditions. this review, we provide some historical, structural, notes so that diverse can be appreciated put into context emerging field mechanobiology. We propose exciting journey exploration will continue for at least another new generation researchers.

Language: Английский

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Crosstalk between mechanotransduction and metabolism

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 22 - 38

Published: Nov. 13, 2020

Language: Английский

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YAP/TAZ functions and their regulation at a glance

Journal of Cell Science, Journal Year: 2020, Volume and Issue: 133(2)

Published: Jan. 15, 2020

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm nucleus in response to multiple inputs, including Hippo pathway. In nucleus, they pair with DNA-binding factors of TEAD family regulate gene expression. Nuclear YAP/TAZ promote cell proliferation, organ overgrowth, survival stress dedifferentiation post-mitotic cells into their respective tissue progenitors. required for growth embryonic tissues, wound healing regeneration, where activated cell-intrinsic extrinsic cues. Surprisingly, this activity is dispensable many adult self-renewing constantly kept check. lay at center a complex regulatory network cell-autonomous but also cell- tissue-level structural features such as mechanical properties microenvironment, establishment cell–cell junctions basolateral polarity. Enhanced levels observed cancers, sustain tumor growth, drug resistance malignancy. Cell Science Glance article accompanying poster, we review biological functions mechanisms, highlight position signaling network.

Language: Английский

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YAP-mediated mechanotransduction tunes the macrophage inflammatory response

Science Advances, Journal Year: 2020, Volume and Issue: 6(49)

Published: Dec. 4, 2020

Macrophages sense biophysical cues in the microenvironment via YAP to tune their inflammatory response.

Language: Английский

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Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate

ACS Nano, Journal Year: 2021, Volume and Issue: 15(1), P. 175 - 209

Published: Jan. 6, 2021

Most tissues of the human body are characterized by highly anisotropic physical properties and biological organization. Hydrogels have been proposed as scaffolding materials to construct artificial due their water-rich composition, biocompatibility, tunable properties. However, unmodified hydrogels typically composed randomly oriented polymer networks, resulting in homogeneous structures with isotropic different from those observed systems. Magnetic potential agents provide anisotropy required for use on tissue engineering. Moreover, intrinsic magnetic nanoparticles enable magnetomechanic remote actuators control behavior cells encapsulated within under application external fields. In this review, we combine a detailed summary main strategies prepare showing controlled an analysis approaches available incorporation into hydrogels. The magnetically responsive nanocomposite engineering is also reviewed.

Language: Английский

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Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

Nature Cell Biology, Journal Year: 2019, Volume and Issue: 21(3), P. 338 - 347

Published: Feb. 4, 2019

Language: Английский

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Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

Genes & Development, Journal Year: 2017, Volume and Issue: 31(23-24), P. 2361 - 2375

Published: Dec. 1, 2017

Both the MRTF-SRF and YAP-TEAD transcriptional regulatory networks respond to extracellular signals mechanical stimuli. We show that pathway is activated in cancer-associated fibroblasts (CAFs). The MRTFs are required addition YAP for CAF contractile proinvasive properties. compared target gene sets identified genes directly regulated by one pathway, other, or both. Nevertheless, two pathways exhibit mutual dependence. In CAFs, expression of direct genomic targets also dependent on activity, and, conversely, signaling. normal fibroblasts, MRTF derivatives activates YAP, while activate MRTF. Cross-talk between requires recruitment DNA via their respective DNA-binding partners (SRF TEAD) therefore indirect, arising as a consequence activation genes. both CAFs we found activity sensitive MRTF-SRF-induced contractility, signaling responds YAP-TEAD-dependent TGFβ Thus, MRF-SRF interact indirectly through ability control cytoskeletal dynamics.

Language: Английский

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Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis

International Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 16(12), P. 2014 - 2028

Published: Jan. 1, 2020

Metastasis is a complicated, multistep process that responsible for over 90% of cancer-related death.Metastatic disease or the movement cancer cells from one site to another requires dramatic remodeling cytoskeleton.The regulation cell migration determined not only by biochemical factors in microenvironment but also biomechanical contextual information provided extracellular matrix (ECM).The responses cytoskeleton chemical signals are well characterized and understood.However, mechanisms response mechanical form externally applied force forces generated ECM still poorly understood.Furthermore, understanding way cellular mechanosensors interact with physical properties transmit activate cytoskeletal movements may help identify an effective strategy treatment cancer.Here, we will discuss role tumor during metastasis how remodel through mechanosensing transduction.

Language: Английский

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