Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala

Cell Reports, Journal Year: 2018, Volume and Issue: 22(4), P. 905 - 918

Published: Jan. 1, 2018

The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including to nucleus accumbens (NAc), medial aspect of central (CeM), ventral hippocampus (vHPC). Although there is consensus regarding existence distinct subsets neurons encoding positive or negative valence, controversy remains anatomical arrangement these populations. First, we map location more than 1,000 distributed across recorded during a Pavlovian discrimination task. Next, determine projection-defined labeled with retrograde tracers use CLARITY reveal axonal path in 3-dimensional space. Finally, examine local influence each populations within BLA. Understanding functional topographical organization circuits underlying valence assignment could fundamental principles about emotional processing.

Language: Английский

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Inhibition in the amygdala anxiety circuitry

Experimental & Molecular Medicine, Journal Year: 2018, Volume and Issue: 50(4), P. 1 - 16

Published: April 1, 2018

Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the anxiolytic effect of benzodiazepine class γ-aminobutyric acid (GABA) receptor agonists and recent discovery anxiety-associated variants molecular components inhibitory synapses. Accordingly, substantial interest has focused on understanding how neurons synapses contribute to circuitry underlying adaptive pathological behaviors. A element is amygdala, which integrates information from cortical thalamic sensory inputs generate fear anxiety-related behavioral outputs. Information processing within amygdala heavily dependent control, although specific mechanisms GABAergic regulate behaviors are only beginning be uncovered. Here, we summarize current state knowledge highlight open questions regarding inhibition circuitry. We discuss neuron subtypes that basolateral central well determinants, such GABA receptors synapse organizer proteins, shape synaptic transmission Finally, conclude with an overview future approaches for converting this into successful treatment strategies disorders. Understanding developing more effective therapeutics against anxiety. Anxiety disorders most prevalent group psychiatric diseases, yet they often under-treated due limited efficacy tolerability approaches. Dilja Krueger-Burg colleagues at Max Planck Institute Experimental Medicine Göttingen, Germany, review neuronal circuits brain region emotions. It established alterations excessive excitatory underlie Using latest technologies identify populations implicated regulation should help develop new targeted treatments fewer side-effects.

Language: Английский

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A neuronal circuit for activating descending modulation of neuropathic pain

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(10), P. 1659 - 1668

Published: Sept. 9, 2019

Language: Английский

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From Structure to Behavior in Basolateral Amygdala-Hippocampus Circuits

Frontiers in Neural Circuits, Journal Year: 2017, Volume and Issue: 11

Published: Oct. 31, 2017

Emotion influences various cognitive processes, including learning and memory. The amygdala is specialized for input processing of emotion, while the hippocampus essential declarative or episodic During emotional reactions, these two brain regions interact to translate emotion into particular outcomes. Here, we briefly introduce anatomy functions hippocampus, then present behavioral, electrophysiological, optogenetic biochemical evidence from recent studies illustrate how work synergistically form long-term With technological advances, causal investigations specific neural circuit between will help us understand mechanisms emotion-regulated memories improve clinical treatment emotion-associated memory disorders in patients.

Language: Английский

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Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning

Cell, Journal Year: 2018, Volume and Issue: 173(6), P. 1329 - 1342.e18

Published: May 1, 2018

Language: Английский

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Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

Neuron, Journal Year: 2017, Volume and Issue: 94(4), P. 731 - 743

Published: May 1, 2017

Language: Английский

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Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning

Biological Psychiatry, Journal Year: 2017, Volume and Issue: 83(10), P. 800 - 809

Published: Oct. 14, 2017

Associative memory formation is essential for an animal's survival by ensuring adaptive behavioral responses in ever-changing environment. This particularly important under conditions of immediate threats such as fear learning. One the key brain regions involved associative learning amygdala. The basolateral amygdala main entry site sensory information to complex, and local plasticity excitatory principal neurons considered be crucial conditioned responses. However, activity circuits are tightly controlled inhibitory interneurons a spatially temporally defined manner. In this review, we provide updated view on how distinct interneuron subtypes contribute acquisition extinction memories.

Language: Английский

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Neural Circuit Motifs in Valence Processing

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 436 - 452

Published: Oct. 1, 2018

Language: Английский

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Integration of Parallel Opposing Memories Underlies Memory Extinction

Cell, Journal Year: 2018, Volume and Issue: 175(3), P. 709 - 722.e15

Published: Sept. 20, 2018

Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show extinction of aversive memories in Drosophila specific dopaminergic neurons, which indicate omission punishment is remembered as positive Functional imaging revealed co-existence intracellular calcium traces different places the mushroom body output neuron network for both original new appetitive memory. Light ultrastructural anatomy are consistent with parallel competing being combined within neurons direct avoidance. Indeed, extinction-evoked plasticity pair these neutralizes potentiated odor response imposed learning. Therefore, flies track accuracy expectations accumulating integrating events.

Language: Английский

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Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction

Translational Psychiatry, Journal Year: 2017, Volume and Issue: 7(8), P. e1194 - e1194

Published: Aug. 8, 2017

The amygdala integrates and processes incoming information pertinent to reward emotions such as fear anxiety that promote survival by warning of potential danger. Basolateral (BLA) communicates bi-directionally with brain regions affecting cognition, motivation stress responses including prefrontal cortex, hippocampus, nucleus accumbens hindbrain trigger norepinephrine-mediated responses. Disruption intrinsic BLA regulatory neurocircuits is often caused dysfunctional neuroplasticity frequently due molecular alterations in local GABAergic circuits principal glutamatergic output neurons. Changes regulation excitability underlie behavioral disturbances characteristic disorders post-traumatic syndrome (PTSD), autism, attention-deficit hyperactivity disorder (ADHD) stress-induced relapse drug use. In this Review, we discuss mechanisms neural regulate physiological dysfunction BLA/amygdala its We consider effects on motivated behaviors depend BLA; these include taking seeking, emphasis nicotine-dependent behaviors. Throughout, take a translational approach integrating decades addiction research animal models human trials. show changes function identified illuminate imaging studies more precisely delineating mechanisms. summary, required responding for natural respond second-order drug-conditioned cues; reinstate cue-dependent seeking; express stress-enhanced reacquisition nicotine intake; drive fear. Converging evidence indicates chronic causes neurons become hyperexcitable.

Language: Английский

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