Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: Nov. 8, 2016

Abstract Rapid variations in cortical state during wakefulness have a strong influence on neural and behavioural responses are tightly coupled to changes pupil size across species. However, the physiological processes linking largely unknown. Here we demonstrate that these rapid variations, both quiet waking locomotion, highly correlated with fluctuations activity of corticopetal noradrenergic cholinergic projections. dilations associated phasic axons, whereas longer-lasting pupil, such as accompanied by sustained axons. Thus, can be used sensitively track multiple neuromodulatory transmitter systems they control brain.

Language: Английский

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Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Neuron, Journal Year: 2016, Volume and Issue: 91(6), P. 1199 - 1218

Published: Sept. 1, 2016

Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning provides compelling evidence that the loss of signaling cognitive decline are inextricably linked. This Review focuses on last few years studies mechanisms by which contributes circuit activity related cognition. We attempt identify areas controversy, as well consensus, what is not yet known about how in CNS processes. In addition, we delineate findings from recent extent dysfunction associated with neurodegenerative disorders.

Language: Английский

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Pupil Size as a Window on Neural Substrates of Cognition

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(6), P. 466 - 480

Published: April 21, 2020

Language: Английский

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Layer-specific modulation of neocortical dendritic inhibition during active wakefulness

Science, Journal Year: 2017, Volume and Issue: 355(6328), P. 954 - 959

Published: March 2, 2017

γ-Aminobutyric acid (GABA)ergic inputs are strategically positioned to gate synaptic integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal dynamics during behavior poorly understood. Using an optical-tagging electrophysiological approach record and label somatostatin-expressing (Sst) interneurons (GABAergic neurons specialized for inhibition), we discovered a layer-specific modulation activity in behaving mice. Sst interneuron subtypes, residing different cortical layers innervating complementary laminar domains, exhibited opposite changes transitions active wakefulness. The relative weight vasoactive intestinal peptide-expressing (Vip) interneuron-mediated inhibition distinct cholinergic determined vivo activity. These results reveal state-dependent influence inhibition, with implications compartmentalized regulation signaling mammalian neocortex.

Language: Английский

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Secondary Motor Cortex: Where ‘Sensory’ Meets ‘Motor’ in the Rodent Frontal Cortex

Trends in Neurosciences, Journal Year: 2016, Volume and Issue: 40(3), P. 181 - 193

Published: Dec. 22, 2016

Language: Английский

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A cortical filter that learns to suppress the acoustic consequences of movement

Nature, Journal Year: 2018, Volume and Issue: 561(7723), P. 391 - 395

Published: Sept. 1, 2018

Language: Английский

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Neuromodulation of Brain State and Behavior

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 391 - 415

Published: April 6, 2020

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans animals reveal that these variations not random their nature, but may fact be due large part to rapid shifts neural, cognitive, behavioral states. Here we review recent advances the understanding waking state, how generated, they modulate neural mice humans. We propose brain has an identifiable set states through which it wanders continuously a nonrandom fashion, owing ascending modulatory fast-acting corticocortical subcortical-cortical pathways. These state provide backdrop upon operates, them is critical making progress revealing mechanisms underlying cognition behavior.

Language: Английский

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Organization of long-range inputs and outputs of frontal cortex for top-down control

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(12), P. 1733 - 1742

Published: Oct. 17, 2016

Language: Английский

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Neuromodulatory Correlates of Pupil Dilation

Frontiers in Neural Circuits, Journal Year: 2018, Volume and Issue: 12

Published: March 8, 2018

Pupillometry has long been used as a measure of brain state. Changes in pupil diameter are thought to coincide with the activity neuromodulators, including noradrenaline and acetylcholine, producing alterations state corresponding changes behavior. Here we review mechanisms underlying control how these correlated cortical recruitment neuromodulatory circuits.

Language: Английский

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The Input-Output Relationship of the Cholinergic Basal Forebrain

Cell Reports, Journal Year: 2017, Volume and Issue: 18(7), P. 1817 - 1830

Published: Feb. 1, 2017

Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and attention. They collectively innervate the entire cerebral cortex, differentially controlling acetylcholine efflux across different areas timescales. Such control might be achieved by differential inputs driving separable outputs, although no input-output relationship on a brain-wide level has ever been demonstrated. Here, we identify input to cells projecting specific regions infecting axon terminals with monosynaptically restricted viral tracer. This approach revealed several circuit motifs, such as central amygdala synapsing onto basolateral amygdala-projecting or strong somatosensory motor cortex-projecting neurons. The presence of in parasympathetic midbrain nuclei contacting frontally suggest that network regulating inner eye muscles are additionally state via efflux. dataset enables future circuit-level experiments drivers known functions.

Language: Английский

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