Neural circuit mechanisms for steering control in walkingDrosophila DOI Creative Commons

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: April 5, 2020

Abstract Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning DOI
Jianzhi Zeng, Xuelin Li, Renzimo Zhang

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1118 - 1135.e5

Published: Jan. 26, 2023

Language: Английский

Citations

44
Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila DOI Creative Commons
Daichi Yamada, Daniel Bushey, Feng Li

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 24, 2023

Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify feedforward circuit formed between dopamine show that essential for second-order conditioning, an ethologically important form of higher-order associative The Drosophila mushroom body comprises series dopaminergic compartments, each which exhibits dynamics. We find slow stable compartment can serve as effective ‘teacher’ by instructing other faster transient compartments via single key interneuron, connectome analysis neurotransmitter prediction. This excitatory interneuron acquires enhanced response to reward-predicting odor after first-order conditioning and, upon activation, evokes release the ‘student’ compartments. These hierarchical connections explain first- long known behavioral psychologists.

Language: Английский

Citations

43
Inhibitory engrams in perception and memory DOI Open Access
Helen C. Barron, Tim P. Vogels, Timothy E.J. Behrens

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(26), P. 6666 - 6674

Published: June 13, 2017

Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected or "engrams" are thought memories of past experience. Multiple lines recent evidence indicate that brain create inhibitory replicas representations for important cognitive functions. Such matched "inhibitory engrams" can form through homeostatic potentiation inhibition onto postsynaptic cells show increased levels excitation. Inhibitory engrams reduce behavioral responses familiar stimuli, thereby resulting in habituation. In addition, by preventing inappropriate activation memory engrams, make quiescent, stored a latent is available context-relevant activation. neural networks with balanced the release innate recall associative occur focused disinhibition. Understanding mechanisms regulate formation expression vivo may help not only explain key features cognition but also provide insight into transdiagnostic traits associated psychiatric conditions such as autism, schizophrenia, posttraumatic stress disorder.

Language: Английский

Citations

148
Re-evaluation of learned information in Drosophila DOI
Johannes Felsenberg, Oliver Barnstedt, Paola Cognigni

et al.

Nature, Journal Year: 2017, Volume and Issue: 544(7649), P. 240 - 244

Published: April 1, 2017

Language: Английский

Citations

146
Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace DOI Creative Commons
Jacob A. Berry, Anna Phan, Ronald L. Davis

et al.

Cell Reports, Journal Year: 2018, Volume and Issue: 25(3), P. 651 - 662.e5

Published: Oct. 1, 2018

It remains unclear how memory engrams are altered by experience, such as new learning, to cause forgetting. Here, we report that short-term aversive in Drosophila is encoded and retrieved from the mushroom body output neuron MBOn-γ2α′1. Pairing an odor with electric shock creates a robust depression calcium response of MBOn-γ2α′1 increases avoidance paired odor. Electric after which activates cognate dopamine DAn-γ2α′1, restores properties causes behavioral Conditioning second responses previously learned while depressing newly odor, showing learning forgetting can occur simultaneously. Moreover, optogenetic activation DAn-γ2α′1 sufficient for bidirectional modulation properties. Thus, single DAn drive both bidirectionally modulating cellular trace.

Language: Английский

Citations

139
Representations of Novelty and Familiarity in a Mushroom Body Compartment DOI Creative Commons
Daisuke Hattori, Yoshinori Aso, Kurtis J. Swartz

et al.

Cell, Journal Year: 2017, Volume and Issue: 169(5), P. 956 - 969.e17

Published: May 1, 2017

Language: Английский

Citations

135
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila DOI Creative Commons
Sercan Sayın, Jean‐François De Backer,

K.P. Siju

et al.

Neuron, Journal Year: 2019, Volume and Issue: 104(3), P. 544 - 558.e6

Published: Aug. 27, 2019

In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion fear. How need motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that flies persistently track food odor increase their effort over repeated trials in absence reward suggesting dominates negative experience. We further tracking regulated by two mushroom body output neurons (MBONs) connecting MB lateral horn. These MBONs, together with dopaminergic Dop1R2 signaling, behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one acts as brake on feeding olfaction. Together, our data suggest function for internal state-dependent expression can be suppressed external inputs conveying competing drive.

Language: Английский

Citations

126
Neural basis of hunger-driven behaviour in Drosophila DOI Creative Commons
Suewei Lin,

Bhagyashree Senapati,

Chang-Hui Tsao

et al.

Open Biology, Journal Year: 2019, Volume and Issue: 9(3)

Published: March 1, 2019

Hunger is a motivational state that drives eating and food-seeking behaviour. In psychological sense, hunger sets the goal guides an animal in pursuit of food. The biological basis underlying this purposive, goal-directed nature has been under intense investigation. With its rich behavioural repertoire genetically tractable nervous system, fruit fly Drosophila melanogaster emerged as excellent model system for studying neural hunger-driven Here, we review our current understanding how sensed, encoded translated into foraging feeding behaviours fly.

Language: Английский

Citations

117
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila DOI Creative Commons
Pedro F. Jacob, Scott Waddell

Neuron, Journal Year: 2020, Volume and Issue: 106(6), P. 977 - 991.e4

Published: April 13, 2020

Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory training frequently compared to that the same number without Here we show that, flies acquire additional information and form an for shock-paired a slowly emerging more persistent "safety-memory" explicitly unpaired odor. Safety-memory acquisition repetition, order, spacing relies on triggering specific rewarding dopaminergic neurons. Co-existence safety memories evident as depression odor-specific responses at different combinations junctions mushroom body output network; combining two outputs appears signal relative safety. Having complementary augments performance by making preference certain.

Language: Английский

Citations

99
Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning DOI Creative Commons
Isaac Cervantes-Sandoval, Anna Phan,

Molee Chakraborty

et al.

eLife, Journal Year: 2017, Volume and Issue: 6

Published: May 10, 2017

Current thought envisions dopamine neurons conveying the reinforcing effect of unconditioned stimulus during associative learning to axons Drosophila mushroom body Kenyon cells for normal olfactory learning. Here, we show using functional GFP reconstitution experiments that and from axoaxonic reciprocal synapses. The receive cholinergic input via nicotinic acetylcholine receptors cells; knocking down these impairs revealing importance at synapse. Blocking synaptic output conditioning reduces presynaptic calcium transients in neurons, a finding consistent with communication. Moreover, silencing decreases chronic activity neurons. Our results reveal new critical role positive feedback onto through connections

Language: Английский

Citations

95