Communication dynamics in complex brain networks

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 19(1), P. 17 - 33

Published: Dec. 14, 2017

Language: Английский

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Linking Structure and Function in Macroscale Brain Networks

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(4), P. 302 - 315

Published: Feb. 25, 2020

The emergence of network neuroscience allows researchers to quantify the link between organizational features neuronal networks and spectrum cortical functions.Current models indicate that structure function are significantly correlated, but correspondence is not perfect because reflects complex multisynaptic interactions in structural networks.Function cannot be directly estimated from structure, must inferred by higher-order interactions. Statistical, communication, biophysical have been used translate brain function.Structure–function coupling regionally heterogeneous follows molecular, cytoarchitectonic, functional hierarchies. Structure–function relationships a fundamental principle many naturally occurring systems. However, research suggests there an imperfect connectivity brain. Here, we synthesize current state knowledge linking macroscale discuss different types assess this relationship. We argue do include requisite biological detail completely predict function. Structural reconstructions enriched with local molecular cellular metadata, concert more nuanced representations functions properties, hold great potential for truly multiscale understanding structure–function relationship central concept natural sciences engineering. Consider how conformation protein determines its chemical properties and, ultimately, folding into 3D promotes among amino acids, allowing chemically interact other molecules endowing it Conversely, disruption protein's results loss Tellingly, said denatured, highlighting idea changing has fundamentally altered nervous system analogously shaped arrangement neurons populations. synaptic projections forms hierarchy (see Glossary) nested increasingly polyfunctional neural circuits support perception, cognition, action. Modern imaging technology permits high-throughput reconstruction across spatiotemporal scales species (Box 1). 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Language: Английский

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A cross-disorder connectome landscape of brain dysconnectivity

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(7), P. 435 - 446

Published: May 24, 2019

Language: Английский

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Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature

NeuroImage, Journal Year: 2017, Volume and Issue: 160, P. 15 - 31

Published: Feb. 2, 2017

Language: Английский

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A Network Model of the Emotional Brain

Trends in Cognitive Sciences, Journal Year: 2017, Volume and Issue: 21(5), P. 357 - 371

Published: March 28, 2017

Language: Английский

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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(9), P. 1157 - 1167

Published: July 6, 2020

Language: Английский

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Chemogenetic Interrogation of a Brain-wide Fear Memory Network in Mice

Neuron, Journal Year: 2017, Volume and Issue: 94(2), P. 363 - 374.e4

Published: April 1, 2017

Language: Английский

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An Open Resource for Non-human Primate Imaging

Neuron, Journal Year: 2018, Volume and Issue: 100(1), P. 61 - 74.e2

Published: Sept. 27, 2018

Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational cross-species comparative neuroscience. Unfortunately, the technological methodological advances past two decades have outpaced accrual data, which particularly challenging given relatively few centers necessary facilities capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human magnetic resonance imaging (MRI) datasets openly sharing them via International Neuroimaging Data-sharing Initiative (INDI). Here, we present rationale, design, procedures for PRIME-DE consortium, as well initial release, consisting 25 independent data collections aggregated across 22 sites (total = 217 primates). We also outline unique pitfalls challenges should be considered in analysis MRI datasets, including providing automated quality assessment contributed datasets.

Language: Английский

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The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations

Neuron, Journal Year: 2018, Volume and Issue: 97(4), P. 940 - 952.e4

Published: Feb. 1, 2018

Language: Английский

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The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research

Neuroscience Letters, Journal Year: 2017, Volume and Issue: 693, P. 58 - 67

Published: Nov. 30, 2017

Language: Английский

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