Neuroscience & Biobehavioral Reviews,
Journal Year:
2020,
Volume and Issue:
120, P. 222 - 235
Published: Nov. 24, 2020
The
ability
to
adapt
dynamic
environments
requires
tracking
multiple
signals
with
variable
sensory
salience
and
fluctuating
behavioral
relevance.
This
complex
process
integrative
crosstalk
between
cognitive
brain
circuits.
Functional
interactions
cortical
thalamic
regions
are
now
considered
essential
for
both
perception
cognition
but
a
clear
account
of
the
functional
link
circuits
is
currently
lacking.
review
aims
document
how
nuclei
may
effectively
act
as
bridge
allowing
fuse
perceptual
events
into
meaningful
experiences.
After
highlighting
key
aspects
thalamocortical
such
classic
first-order/higher-order
dichotomy,
we
consider
role
reticular
nucleus
from
directed
attention
cognition.
We
next
summarize
research
relying
on
Pavlovian
learning
paradigms,
showing
that
first-order
higher-order
contribute
associative
learning.
Finally,
propose
modulator
inputs
reaching
all
be
critical
purposes
when
environmental
computed.
Altogether,
thalamus
appears
linking
perception,
possibly
affect.
Hippocampus,
Journal Year:
2018,
Volume and Issue:
28(10), P. 745 - 764
Published: July 10, 2018
Abstract
The
dynamic
process
of
memory
consolidation
involves
a
reorganization
brain
regions
that
support
trace
over
time,
but
exactly
how
the
network
reorganizes
as
changes
remains
unclear.
We
present
novel
converging
evidence
from
studies
animals
(rats)
and
humans
for
time‐dependent
transformation
different
types
measured
both
by
behavior
activation.
find
context‐specific
memories
in
rats,
naturalistic
episodic
humans,
lose
precision
time
activity
hippocampus
decreases.
If,
however,
retrieved
retain
contextual
or
perceptual
detail,
is
engaged
similarly
at
recent
remote
timepoints.
As
interval
between
timepoint
increases,
medial
prefrontal
cortex
increasingly
during
retrieval,
regardless
context
amount
detail.
Moreover,
these
hippocampal‐frontal
shifts
are
accompanied
corresponding
cortical
structures
mediating
perceptually‐detailed
well
less
precise,
schematic
memories.
These
findings
provide
cross‐species
crucial
interplay
neocortex
reflects
representation
underlies
systems
consolidation.
Proceedings of the National Academy of Sciences,
Journal Year:
2020,
Volume and Issue:
117(4), P. 2149 - 2159
Published: Jan. 14, 2020
Significance
Visualizing
functional
changes
in
brain
networks
that
are
produced
by
alcohol
use
and
dependence
is
a
critical
step
our
understanding
of
the
consequences
drinking
alcohol.
Because
technical
limitations,
visualizing
throughout
whole
at
single-cell
resolution
has
not
been
possible.
The
present
study
used
whole-brain
imaging
approach
mice
to
assess
whether
abstinence
alters
architecture
brain.
Compared
with
nondrinkers
casual
drinkers,
alcohol-dependent
exhibited
widespread
increases
coordinated
activity
during
decrease
modularity.
We
also
identified
target
regions
for
future
research
provide
atlas
may
be
better
understand
use,
dependence,
abstinence.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: May 24, 2019
Encoding
and
retrieval
of
contextual
memories
is
initially
mediated
by
sparsely
activated
neurons,
so-called
engram
cells,
in
the
hippocampus.
Subsequent
memory
persistence
thought
to
depend
on
network-wide
changes
involving
progressive
contribution
cortical
regions,
a
process
referred
as
systems
consolidation.
Using
viral-based
TRAP
(targeted
recombination
populations)
approach,
we
studied
whether
consolidation
fear
neurons
medial
prefrontal
cortex
(mPFC)
modulated
strength
CREB
function.
We
demonstrate
that
activity
small
subset
mPFC
sufficient
necessary
for
remote
expression,
but
their
involvement
depends
conditioning.
Furthermore,
selective
disruption
function
cells
after
mild
conditioning
impairs
expression.
Together,
our
data
requires
CREB-mediated
transcription,
with
functionality
this
network
hub
being
gated
strength.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2020,
Volume and Issue:
120, P. 222 - 235
Published: Nov. 24, 2020
The
ability
to
adapt
dynamic
environments
requires
tracking
multiple
signals
with
variable
sensory
salience
and
fluctuating
behavioral
relevance.
This
complex
process
integrative
crosstalk
between
cognitive
brain
circuits.
Functional
interactions
cortical
thalamic
regions
are
now
considered
essential
for
both
perception
cognition
but
a
clear
account
of
the
functional
link
circuits
is
currently
lacking.
review
aims
document
how
nuclei
may
effectively
act
as
bridge
allowing
fuse
perceptual
events
into
meaningful
experiences.
After
highlighting
key
aspects
thalamocortical
such
classic
first-order/higher-order
dichotomy,
we
consider
role
reticular
nucleus
from
directed
attention
cognition.
We
next
summarize
research
relying
on
Pavlovian
learning
paradigms,
showing
that
first-order
higher-order
contribute
associative
learning.
Finally,
propose
modulator
inputs
reaching
all
be
critical
purposes
when
environmental
computed.
Altogether,
thalamus
appears
linking
perception,
possibly
affect.
