How Can Hearing Loss Cause Dementia?

Neuron, Journal Year: 2020, Volume and Issue: 108(3), P. 401 - 412

Published: Aug. 31, 2020

Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account 9% of cases. We evaluate candidate brain bases this relationship. These include a common pathology affecting the ascending auditory pathway and multimodal cortex, depletion cognitive reserve due impoverished listening environment, occupation resources when in difficult conditions. also put forward alternate mechanism, drawing on new insights into role medial temporal lobe cognition. In particular, we consider how aberrant activity service pattern analysis, working memory, object processing may interact with dementia people loss. highlight effect interventions depends specific mechanism suggest avenues work at molecular, neuronal, systems levels pin down.

Language: Английский

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Alternating sources of perisomatic inhibition during behavior

Neuron, Journal Year: 2021, Volume and Issue: 109(6), P. 997 - 1012.e9

Published: Feb. 1, 2021

Language: Английский

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Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences

Neuron, Journal Year: 2022, Volume and Issue: 110(12), P. 1978 - 1992.e6

Published: April 20, 2022

Language: Английский

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Local feedback inhibition tightly controls rapid formation of hippocampal place fields

Neuron, Journal Year: 2022, Volume and Issue: 110(5), P. 783 - 794.e6

Published: Jan. 5, 2022

Language: Английский

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Neural dynamics underlying associative learning in the dorsal and ventral hippocampus

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(5), P. 798 - 809

Published: April 3, 2023

Language: Английский

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Decision-making dynamics are predicted by arousal and uninstructed movements

Cell Reports, Journal Year: 2024, Volume and Issue: 43(2), P. 113709 - 113709

Published: Jan. 26, 2024

During sensory-guided behavior, an animal's decision-making dynamics unfold through sequences of distinct performance states, even while stimulus-reward contingencies remain static. Little is known about the factors that underlie these changes in task performance. We hypothesize can be predicted by externally observable measures, such as uninstructed movements and arousal. Here, using computational modeling visual auditory data from mice, we uncovered lawful relationships between transitions strategic states arousal movements. Using hidden Markov models applied to behavioral choices during sensory discrimination tasks, find animals fluctuate minutes-long optimal, sub-optimal, disengaged states. Optimal state epochs are intermediate levels, reduced variability, pupil diameter movement. Our results demonstrate behaviors predict optimal suggest mice regulate their

Language: Английский

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The hearing hippocampus

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 218, P. 102326 - 102326

Published: July 20, 2022

The hippocampus has a well-established role in spatial and episodic memory but broader function been proposed including aspects of perception relational processing. Neural bases sound analysis have described the pathway to auditory cortex, wider networks supporting cognition are still being established. We review what is known about processing information, how itself shaped by sound. In examining imaging, recording, lesion studies species from rodents humans, we uncover hierarchy hippocampal responses during passive exposure, active listening, learning associations between sounds other stimuli. describe hippocampus' connectivity computational architecture allow it track manipulate information – whether form speech, music, or environmental, emotional, phantom sounds. Functional structural correlates experience also identified. extent auditory-hippocampal interactions consistent with view that makes broad contributions cognition, beyond memory. More deeply understanding these may unlock applications entraining rhythms support intervening links hearing loss dementia.

Language: Английский

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CA1 Engram Cell Dynamics Before and After Learning

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 20, 2024

Summary A fundamental question in neuroscience is how memory formation shapes brain activity at the level of populations neurons. Recent studies hippocampal ‘engram’ cells, identified by immediate-early genes (IEGs) induced learning, propose that these act as a neuronal substrate for storage. The current framework engram proposes cells join ensembles based on increased intrinsic excitability, and after initial they co-activate to support retrieval. However, direct evidence population dynamics evolve across learning limited. Here we combined activity-dependent genetic tagging two-photon calcium imaging characterize CA1 before learning. We observed spontaneous two days predicted tagging, consistent with model which fluctuations bias into forming assemblies. Surprisingly, were unable detect rates or pairwise correlations amongst tagged neurons These results computational network models incorporate strong specific inhibitory connections, supporting idea excitatory/inhibitory balance may play key role dynamics. Together highlight potential slow time scale excitability driving suggest excitatory-inhibitory regulate cell co-activation. Highlights Tracked Fos Spontaneous predicts TetTagging. No changes TetTagged Modeling suggests E/I regulates

Language: Английский

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Adaptive stimulus selection for consolidation in the hippocampus

Nature, Journal Year: 2021, Volume and Issue: 601(7892), P. 240 - 244

Published: Dec. 8, 2021

Language: Английский

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Associations of sensory impairment and cognitive function in middle-aged and older Chinese population: The China Health and Retirement Longitudinal Study

Journal of Global Health, Journal Year: 2021, Volume and Issue: 11

Published: Dec. 18, 2021

Little is known about the associations between vision impairment, hearing and cognitive function. The aim of this study was to examine whether impairment were associated with a high risk for in middle-aged older Chinese adults.A total 13 914 adults from China Health Retirement Longitudinal Study (CHARLS) baseline selected analysis. Sensory assessed single self-report question, we categorized sensory into four groups: no dual impairment. Cognitive assessment covered memory, mental state, cognition, data obtained through questionnaire.Memory negatively (β = -0.043, 95% confidence interval (CI) -0.076, -0.043) -0.033, CI -0.049, -0.017); status -0.034, -0.018), -0.070, -0.086, -0.055), -0.054, -0.039); cognition -0.028, -0.044, -0.013), -0.074, -0.090, -0.059), -0.052, -0.067, -0.036), even after adjusting demographics, social economic factors, lifestyle behavior.Vision are status, elderly adults. There stronger negative cognitive-related indicators compared middle-aged.

Language: Английский

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