Haptic
perception
synthesizes
touch
with
proprioception,
the
sense
of
body
position.
Humans
and
mice
alike
experience
rich
active
face.
Because
most
facial
muscles
lack
proprioceptor
endings,
sensory
basis
proprioception
remains
unsolved.
Facial
may
instead
rely
on
mechanoreceptors
that
encode
both
self-motion.
In
rodents,
whisker
provide
a
signal
informs
brain
about
Whisking
involves
coordinated
orofacial
movements,
so
innervating
regions
other
than
whiskers
could
also
information
whisking.
To
define
all
sources
whisking
available
to
brain,
we
recorded
spikes
from
diverse
parts
Whisker
motion
was
encoded
best
by
mechanoreceptors,
but
those
pad
hairy
skin
supraorbital
vibrissae.
Redundant
self-motion
responses
stable
proprioceptive
despite
mechanical
perturbations
during
touch.
Cell,
Journal Year:
2023,
Volume and Issue:
186(3), P. 577 - 590.e16
Published: Jan. 23, 2023
Pleasurable
touch
is
paramount
during
social
behavior,
including
sexual
encounters.
However,
the
identity
and
precise
role
of
sensory
neurons
that
transduce
remain
unknown.
A
population
labeled
by
developmental
expression
G
protein-coupled
receptor
Mrgprb4
detects
mechanical
stimulation
in
mice.
Here,
we
study
relevance
Mrgprb4-lineage
reveal
these
are
required
for
receptivity
sufficient
to
induce
dopamine
release
brain.
Even
isolation,
optogenetic
through
back
skin
a
conditioned
place
preference
striking
dorsiflexion
resembling
lordotic
copulatory
posture.
In
absence
neurons,
female
mice
no
longer
find
male
mounts
rewarding:
supplanted
aggression
coincident
decline
nucleus
accumbens.
Together,
findings
establish
initiate
skin-to-brain
circuit
encoding
rewarding
quality
touch.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 6, 2024
Abstract
Manipulating
the
expression
of
synaptic
plasticity
neuromorphic
devices
provides
fascinating
opportunities
to
develop
hardware
platforms
for
artificial
intelligence.
However,
great
efforts
have
been
devoted
exploring
biomimetic
mechanisms
simulation
in
last
few
years.
Recent
progress
various
modulation
techniques
has
pushed
research
electronics
from
static
dynamic
modulation,
improving
accuracy
computing
and
providing
strategies
implementing
sensing
functions.
Herein,
several
through
chemical
techniques,
device
structure
design,
physical
signal
are
reviewed.
For
underlying
modification
functional
materials
were
clarified
its
effect
on
was
also
highlighted.
Based
reconfigurable
operation
well
demonstrated
achieve
programmable
Besides,
integrating
sensory
units
with
processing
circuits
paved
a
new
way
human-like
intelligent
perception
under
signals
such
as
light,
strain,
temperature.
Finally,
considering
that
relevant
technology
is
still
basic
exploration
stage,
some
prospects
or
development
suggestions
put
forward
promote
devices.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 18, 2025
Perception,
a
cognitive
construct,
emerges
through
sensorimotor
integration
(SMI).
The
genetic
mechanisms
that
shape
SMI
required
for
perception
are
unknown.
Here,
we
demonstrate
in
mice
expression
of
the
autism/intellectual
disability
gene,
Syngap1,
cortical
excitatory
neurons
is
formation
somatomotor
networks
promote
SMI-mediated
perception.
Cortical
Syngap1
was
necessary
and
sufficient
setting
tactile
sensitivity,
sustaining
object
exploration,
promoting
learning.
Mice
with
deficient
exhibited
impaired
neural
dynamics
induced
by
exploratory
touches
within
cortical-thalamic
network
promotes
attention
Disrupted
neuronal
were
associated
circuit-specific
long-range
synaptic
connectivity
abnormalities.
Our
data
support
model
where
autonomous
abilities
assembly
circuits
integrate
temporally-overlapping
sensory
motor
signals,
process
attention.
These
provide
systems-level
insights
into
robust
association
between
ability.
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
101(1), P. 353 - 415
Published: Aug. 20, 2020
The
array
of
whiskers
on
the
snout
provides
rodents
with
tactile
sensory
information
relating
to
size,
shape
and
texture
objects
in
their
immediate
environment.
Rodents
can
use
detect
stimuli,
distinguish
textures,
locate
navigate.
Important
aspects
whisker
sensation
are
thought
result
from
neuronal
computations
somatosensory
cortex
(wS1).
Each
is
individually
represented
somatotopic
map
wS1
by
an
anatomical
unit
named
a
‘barrel’
(hence
also
called
barrel
cortex).
This
allows
precise
investigation
processing
context
well-defined
map.
Here,
we
first
review
signaling
pathways
wS1,
then
discuss
current
understanding
various
types
excitatory
inhibitory
neurons
present
within
wS1.
Different
classes
cells
be
defined
according
anatomical,
electrophysiological
molecular
features.
synaptic
connectivity
local
microcircuits,
as
well
long-range
interactions
impact
neuromodulators,
beginning
understood.
Recent
technological
progress
has
allowed
cell-type-specific
related
activity
during
whisker-related
behaviors.
An
important
goal
for
future
research
obtain
causal
mechanistic
how
selected
processed
specific
synaptically
connected
networks
signaled
downstream
brain
areas,
thus
contributing
sensory-guided
decision-making.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(24)
Published: June 9, 2022
Tactile
perception
enabled
by
somatosensory
system
in
human
is
essential
for
dexterous
tool
usage,
communication,
and
interaction.
Imparting
tactile
recognition
functions
to
advanced
robots
interactive
systems
can
potentially
improve
their
cognition
intelligence.
Here,
a
flexible
artificial
sensory
nerve
that
mimics
the
sensing,
neural
coding,
synaptic
processing
developed
achieve
neuromorphic
at
device
level
without
relying
on
algorithms
or
computing
resources.
An
interfacial
self-assembly
technique,
which
produces
uniform
defect-less
thin
film
of
semiconductor
nanoparticles
arbitrary
substrates,
employed
prepare
device.
The
facilitation
memory
characteristics
proton-gating
enable
this
identify
material
hardness
during
robotic
grasping
recognize
tapping
patterns
interaction
continuous,
real-time,
high-accuracy
manner,
demonstrating
intelligence
capabilities.
This
produced
wearable
portable
form
be
readily
integrated
with
smart
human-machine
interfaces
implementing
human-like
electronics
toward
applications.
