Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(8), P. 1172 - 1179

Published: June 26, 2017

Language: Английский

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Single-trial neural dynamics are dominated by richly varied movements

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(10), P. 1677 - 1686

Published: Sept. 24, 2019

Language: Английский

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Distributed coding of choice, action and engagement across the mouse brain

Nature, Journal Year: 2019, Volume and Issue: 576(7786), P. 266 - 273

Published: Nov. 27, 2019

Language: Английский

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Genetic Dissection of Neural Circuits: A Decade of Progress

Neuron, Journal Year: 2018, Volume and Issue: 98(2), P. 256 - 281

Published: April 1, 2018

Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have carried out in a multitude invertebrate vertebrate organisms, linking neurons to behavioral functions. New methods allow systematic classification cell types provide access diverse neuronal for connectivity coding during behavior. Here we evaluate key advances over the past decade discuss future directions.

Language: Английский

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Thirst regulates motivated behavior through modulation of brainwide neural population dynamics

Science, Journal Year: 2019, Volume and Issue: 364(6437)

Published: April 19, 2019

Neuron activity across the brain How is it that groups of neurons dispersed through interact to generate complex behaviors? Three papers in this issue present brain-scale studies neuronal and dynamics (see Perspective by Huk Hart). Allen et al. found thirsty mice, there widespread neural related stimuli elicit licking drinking. Individual encoded task-specific responses, but every area contained with different types response. Optogenetic stimulation thirst-sensing one reinstated drinking previously signaled thirst. Gründemann investigated mouse basal amygdala relation behavior during tasks. Two ensembles showed orthogonal exploratory nonexploratory behaviors, possibly reflecting levels anxiety experienced these areas. Stringer analyzed spontaneous firing, finding primary visual cortex both information motor facial movements. The variability responses mainly arousal reflects encoding latent behavioral states. Science , p. eaav3932 eaav8736 eaav7893 ; see also 236

Language: Английский

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Neural mechanisms of movement planning: motor cortex and beyond

Current Opinion in Neurobiology, Journal Year: 2017, Volume and Issue: 49, P. 33 - 41

Published: Nov. 21, 2017

Language: Английский

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Systemic AAV vectors for widespread and targeted gene delivery in rodents

Nature Protocols, Journal Year: 2019, Volume and Issue: 14(2), P. 379 - 414

Published: Jan. 8, 2019

Language: Английский

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Neuromodulation by the immune system: a focus on cytokines

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(8), P. 526 - 541

Published: March 1, 2021

Language: Английский

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Gene therapy for neurological disorders: progress and prospects

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 17(9), P. 641 - 659

Published: Aug. 10, 2018

Language: Английский

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AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 25(1), P. 106 - 115

Published: Dec. 9, 2021

Language: Английский

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