Proceedings of the National Academy of Sciences,
Journal Year:
2023,
Volume and Issue:
120(2)
Published: Jan. 5, 2023
One
of
the
essential
functions
biological
neural
networks
is
processing
information.
This
includes
everything
from
sensory
information
to
perceive
environment,
up
motor
interact
with
environment.
Due
methodological
limitations,
it
has
been
historically
unclear
how
changes
during
different
cognitive
or
behavioral
states
and
what
extent
processed
within
between
network
neurons
in
brain
areas.
In
this
study,
we
leverage
recent
advances
calculation
dynamics
explore
neural-level
frontoparietal
areas
AIP,
F5,
M1
a
delayed
grasping
task
performed
by
three
macaque
monkeys.
While
was
high
all
task,
interareal
varied
widely:
During
visuomotor
transformation,
AIP
F5
formed
reciprocally
connected
unit,
while
no
present
memory
period.
Movement
execution
globally
across
predominance
feedback
direction.
Furthermore,
fine-scale
structure
reconfigured
at
neuron
level
response
conditions,
despite
differences
overall
amount
present.
These
results
suggest
that
dynamically
form
higher-order
units
according
demand
information-processing
hierarchically
organized
level,
coarse
determining
state
finer
reflecting
conditions.
Science,
Journal Year:
2021,
Volume and Issue:
372(6539)
Published: April 15, 2021
Measuring
the
dynamics
of
neural
processing
across
time
scales
requires
following
spiking
thousands
individual
neurons
over
milliseconds
and
months.
To
address
this
need,
we
introduce
Neuropixels
2.0
probe
together
with
newly
designed
analysis
algorithms.
The
has
more
than
5000
sites
is
miniaturized
to
facilitate
chronic
implants
in
small
mammals
recording
during
unrestrained
behavior.
High-quality
recordings
long
were
reliably
obtained
mice
rats
six
laboratories.
Improved
site
density
arrangement
combined
created
data
methods
enable
automatic
post
hoc
correction
for
brain
movements,
allowing
from
same
2
These
probes
algorithms
stable
free
behavior,
even
animals
such
as
mice.
Annual Review of Neuroscience,
Journal Year:
2020,
Volume and Issue:
43(1), P. 391 - 415
Published: April 6, 2020
Neural
activity
and
behavior
are
both
notoriously
variable,
with
responses
differing
widely
between
repeated
presentation
of
identical
stimuli
or
trials.
Recent
results
in
humans
animals
reveal
that
these
variations
not
random
their
nature,
but
may
fact
be
due
large
part
to
rapid
shifts
neural,
cognitive,
behavioral
states.
Here
we
review
recent
advances
the
understanding
waking
state,
how
generated,
they
modulate
neural
mice
humans.
We
propose
brain
has
an
identifiable
set
states
through
which
it
wanders
continuously
a
nonrandom
fashion,
owing
ascending
modulatory
fast-acting
corticocortical
subcortical-cortical
pathways.
These
state
provide
backdrop
upon
operates,
them
is
critical
making
progress
revealing
mechanisms
underlying
cognition
behavior.
