Learning with reinforcement prediction errors in a model of the Drosophila mushroom body DOI Creative Commons
James Bennett, Andrew Philippides, Thomas Nowotny

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 7, 2021

Abstract Effective decision making in a changing environment demands that accurate predictions are learned about outcomes. In Drosophila , such learning is orchestrated part by the mushroom body, where dopamine neurons signal reinforcing stimuli to modulate plasticity presynaptic body output neurons. Building on previous models, which absolute reinforcement, we propose instead reinforcement prediction errors utilising feedback from We formulate rules minimise errors, verify learn simulations, and postulate connectivity explains more physiological observations than an experimentally constrained model. The augmented models reproduce broad range of conditioning blocking experiments, demonstrate absence does not imply error dependent learning. Our results provide five can be tested using established experimental methods.

Language: Английский

Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace DOI Creative Commons
Jacob A. Berry, Anna Phan, Ronald L. Davis

et al.

Cell Reports, Journal Year: 2018, Volume and Issue: 25(3), P. 651 - 662.e5

Published: Oct. 1, 2018

It remains unclear how memory engrams are altered by experience, such as new learning, to cause forgetting. Here, we report that short-term aversive in Drosophila is encoded and retrieved from the mushroom body output neuron MBOn-γ2α′1. Pairing an odor with electric shock creates a robust depression calcium response of MBOn-γ2α′1 increases avoidance paired odor. Electric after which activates cognate dopamine DAn-γ2α′1, restores properties causes behavioral Conditioning second responses previously learned while depressing newly odor, showing learning forgetting can occur simultaneously. Moreover, optogenetic activation DAn-γ2α′1 sufficient for bidirectional modulation properties. Thus, single DAn drive both bidirectionally modulating cellular trace.

Language: Английский

Citations

139
Hydrogels as dynamic memory with forgetting ability DOI Open Access
Chengtao Yu, Honglei Guo, Kunpeng Cui

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(32), P. 18962 - 18968

Published: July 27, 2020

Significance Life provides the best demonstration of complex and adaptive nonequilibrium system, which executes biological functions through structure transformation. Creating lifelike materials to achieve part or full is a grand challenge. Traditional memories from hard dry are static, with no ability forgetting; here we propose use soft wet hydrogels dynamic spontaneous but learning-strength-dependent forgetting by using transformation, in analogy human brain. We believe concept memorizing–forgetting behavior proposed inspires further research on developing based process matter.

Language: Английский

Citations

94
Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila DOI Creative Commons

Sophie Himmelreich,

Ikuo Masuho, Jacob A. Berry

et al.

Cell Reports, Journal Year: 2017, Volume and Issue: 21(8), P. 2074 - 2081

Published: Nov. 1, 2017

Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed mushroom body neurons. Active forgetting mediated another Damb, the same Surprisingly, prior both receptors stimulate cyclic AMP (cAMP) accumulation, presenting an enigma of how neurons distinguish between acquisition and signals. Here, we surveyed spectrum G protein coupling dDA1 confirmed can couple to Gs cAMP synthesis. However, Damb receptor uniquely activates Gq mobilize Ca2+ signaling with greater efficiency sensitivity. The knockdown Gαq RNAi in bodies inhibits but has no effect acquisition. Our findings identify Damb/Gq-signaling pathway stimulates resolves opposing effects forgetting.

Language: Английский

Citations

93
RNA-binding proteins balance brain function in health and disease DOI Creative Commons
Rico Schieweck, Jovica Ninkovic, Michael Kiebler

et al.

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(3), P. 1309 - 1370

Published: Oct. 1, 2020

Posttranscriptional gene expression including splicing, RNA transport, translation, and decay provides an important regulatory layer in many if not all molecular pathways. Research the last decades has positioned RNA-binding proteins (RBPs) right center of posttranscriptional regulation. Here, we propose interdependent networks RBPs to regulate complex pathways within central nervous system (CNS). These are involved multiple aspects neuronal development functioning, higher cognition. Therefore, it is sufficient unravel individual contribution a single RBP its consequences but rather study understand tight interplay between different RBPs. In this review, summarize recent findings field biology discuss Second, emphasize underlying dynamics network how might key processes such as neurogenesis, synaptic transmission, plasticity. Importantly, envision that dysfunction specific could lead perturbation network. This would have direct indirect (compensatory) effects mRNA binding translational control leading global changes cellular programs general plasticity particular. focus on cause neuropsychiatric neurodegenerative disorders. Based findings, alterations entire account for phenotypic dysfunctions observed diseases neurodegeneration, epilepsy, autism spectrum

Language: Английский

Citations

78
Dopamine-based mechanism for transient forgetting DOI

John Martin Sabandal,

Jacob A. Berry, Ronald L. Davis

et al.

Nature, Journal Year: 2021, Volume and Issue: 591(7850), P. 426 - 430

Published: Jan. 20, 2021

Language: Английский

Citations

60
Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research DOI Creative Commons
Ronald L. Davis

Genetics, Journal Year: 2023, Volume and Issue: 224(4)

Published: May 22, 2023

Abstract In the last decade, researchers using Drosophila melanogaster have made extraordinary progress in uncovering mysteries underlying learning and memory. This has been propelled by amazing toolkit available that affords combined behavioral, molecular, electrophysiological, systems neuroscience approaches. The arduous reconstruction of electron microscopic images resulted a first-generation connectome adult larval brain, revealing complex structural interconnections between memory-related neurons. serves as substrate for future investigations on these connections building complete circuits from sensory cue detection to changes motor behavior. Mushroom body output neurons (MBOn) were discovered, which individually forward information discrete non-overlapping compartments axons mushroom (MBn). These mirror previously discovered tiling inputs dopamine led model ascribes valence event, either appetitive or aversive, activity different populations balance MBOn promoting avoidance approach Studies calyx, houses MBn dendrites, revealed beautiful microglomeruluar organization synapses occur with long-term memory (LTM) formation. Larval advanced, positioning it possibly lead producing new conceptual insights due its markedly simpler structure over brain. Advances how cAMP response element-binding protein interacts kinases other transcription factors promote formation LTM. New Orb2, prion-like forms oligomers enhance synaptic synthesis required LTM Finally, research pioneered our understanding mechanisms mediate permanent transient active forgetting, an important function brain along acquisition, consolidation, retrieval. was catalyzed partly identification suppressor genes—genes whose normal is limit

Language: Английский

Citations

38
Incorporating neuro-inspired adaptability for continual learning in artificial intelligence DOI
Liyuan Wang,

Xingxing Zhang,

Qian Li

et al.

Nature Machine Intelligence, Journal Year: 2023, Volume and Issue: 5(12), P. 1356 - 1368

Published: Nov. 16, 2023

Language: Английский

Citations

32
Social Isolation Induces Rac1-Dependent Forgetting of Social Memory DOI Creative Commons
Yunlong Liu, Li Lv,

Lianzhang Wang

et al.

Cell Reports, Journal Year: 2018, Volume and Issue: 25(2), P. 288 - 295.e3

Published: Oct. 1, 2018

Social isolation (SI) has detrimental effects on human and animal cognitive functions. In particular, acute in adult mice impairs social recognition memory (SRM). Previous accounts of this impairment have focused primarily consolidation. However, the current study suggests that impaired SRM results from enhanced forgetting. SI accelerates decay without affecting formation. The is caused by elevated Rac1 activity hippocampus. Using adeno-associated-virus-based genetic manipulation, we found inhibition blocked forgetting isolated mice, whereas activation accelerated group-housed mice. Moreover, resocialization reversed following correlation with suppression activity. addition, long-term potentiation (LTP) brain slices was rescued Taken together, findings lead us to conclude deficits are mediated Rac1-dependent

Language: Английский

Citations

60
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila DOI
Hoger Amin, Andrew C. Lin

Current Opinion in Insect Science, Journal Year: 2019, Volume and Issue: 36, P. 9 - 17

Published: June 8, 2019

Language: Английский

Citations

60
The many faces of forgetting: Toward a constructive view of forgetting in everyday life. DOI
Jonathan M. Fawcett, Justin C. Hulbert

Journal of Applied Research in Memory and Cognition, Journal Year: 2020, Volume and Issue: 9(1), P. 1 - 18

Published: Jan. 21, 2020

Language: Английский

Citations

58