Acta Neuropathologica Communications,
Journal Year:
2019,
Volume and Issue:
7(1)
Published: July 5, 2019
Tauopathies
are
a
heterogenous
class
of
diseases
characterized
by
cellular
accumulation
aggregated
tau
and
include
such
as
Alzheimer's
disease
(AD),
progressive
supranuclear
palsy
chronic
traumatic
encephalopathy.
Tau
pathology
is
strongly
linked
to
neurodegeneration
clinical
symptoms
in
tauopathy
patients.
Furthermore,
synapse
loss
an
early
pathological
event
tauopathies
the
strongest
correlate
cognitive
decline.
additionally
associated
with
neuroinflammatory
processes,
reactive
microglia,
astrocytes,
increased
levels
pro-inflammatory
molecules
(e.g.
complement
proteins,
cytokines).
Recent
studies
show
that
principal
immune
cells
brain,
microglia
play
particularly
important
role
initiation
progression
neurodegeneration.
AD
risk
genes
Triggering
receptor
expressed
on
myeloid
2
(TREM2)
Apolipoprotein
E
(APOE)
enriched
innate
system
modulate
response
pathology.
Microglia
can
active
synaptic
dysfunction
abnormally
phagocytosing
compartments
neurons
involved
spreading
-
process
which
thought
underlie
nature
propagation
through
brain.
Spreading
also
predominant
target
for
tau-based
immunotherapy.
Active
vaccines,
therapeutic
antibodies
other
approaches
targeting
actively
explored
treatment
options
tauopathies.
This
review
describes
pathobiology
mechanism
action
potential
therapeutics
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: Nov. 30, 2018
Microglia
are
yolk
sac-derived
macrophages
residing
in
the
parenchyma
of
brain
and
spinal
cord,
where
they
interact
with
neurons
other
glial.
After
different
conditioning
paradigms
bone
marrow
(BM)
or
hematopoietic
stem
cell
(HSC)
transplantation,
graft-derived
cells
seed
persistently
contribute
to
parenchymal
macrophage
compartment.
Here
we
establish
that
acquire,
over
time,
microglia
characteristics,
including
ramified
morphology,
longevity,
radio-resistance
clonal
expansion.
However,
even
after
prolonged
CNS
residence,
transcriptomes
chromatin
accessibility
landscapes
engrafted,
BM-derived
remain
distinct
from
host
microglia.
Furthermore,
engrafted
display
discrete
responses
peripheral
endotoxin
challenge,
as
compared
In
human
HSC
transplant
recipients,
also
microglia,
extending
our
finding
clinical
settings.
Collectively,
data
emphasize
molecular
functional
heterogeneity
highlight
potential
implications
for
gene
therapies
aimed
ameliorate
lysosomal
storage
disorders,
microgliopathies
general
monogenic
immuno-deficiencies.
Science,
Journal Year:
2019,
Volume and Issue:
367(6477), P. 528 - 537
Published: Dec. 13, 2019
Microglia
are
the
main
immune
cells
in
brain
and
have
roles
homeostasis
neurological
diseases.
Mechanisms
underlying
microglia-neuron
communication
remain
elusive.
Here,
we
identified
an
interaction
site
between
neuronal
cell
bodies
microglial
processes
mouse
human
brain.
Somatic
junctions
a
specialized
nanoarchitecture
optimized
for
purinergic
signaling.
Activity
of
mitochondria
was
linked
with
junction
formation,
which
induced
rapidly
response
to
activation
blocked
by
inhibition
P2Y12
receptors.
Brain
injury-induced
changes
at
somatic
triggered
receptor-dependent
neuroprotection,
regulating
calcium
load
functional
connectivity.
Thus,
these
could
potentially
monitor
protect
functions.
Science,
Journal Year:
2020,
Volume and Issue:
367(6478), P. 688 - 694
Published: Feb. 7, 2020
Microglia
modulate
memories
Synaptic
reorganization
and
circuit
rewiring
leads
to
loss
or
weakening
of
connections
between
neurons
may
result
in
the
erasure
previously
formed
memories.
eliminate
excessive
synapses
developing
brain
regulate
dynamics
synaptic
throughout
life.
However,
it
is
still
unclear
whether
forgetting
related
microglia
activity
how
memory
adult
brain.
Wang
et
al.
discovered
that
eliminated
components
hippocampus
depleting
inhibiting
phagocytosis
prevented
forgetting.
Synapse
elimination
by
thus
lead
degradation
engrams
learned
contextual
fear
memory.
Science
,
this
issue
p.
688
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: July 16, 2020
Based
on
discoveries
enabled
by
new
technologies
and
analyzed
using
novel
computational
tools,
neuroscience
can
be
re-conceived
in
terms
of
information
exchange
dense
networks
intercellular
connections
rather
than
the
context
individual
populations,
such
as
glia
or
neurons..
Cross-talk
between
neurons
microglia
astrocytes
are
has
been
addressed,
however,
manner
which
non-neuronal
cells
communicate
interact
remains
less
well
understood.
We
review
this
intriguing
crosstalk
among
CNS
cells,
focusing
how
it
contributes
to
brain
development
two
neurodegenerative
diseases:
Alzheimer
disease
GRN-FTLD
most
prevalent
tumor,
astrocytoma.
The
goal
studying
these
communications
is
promote
our
ability
combat
incurable
neurological
disorders.
