Single-trial neural dynamics are dominated by richly varied movements

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(10), P. 1677 - 1686

Published: Sept. 24, 2019

Language: Английский

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Deep posteromedial cortical rhythm in dissociation

Nature, Journal Year: 2020, Volume and Issue: 586(7827), P. 87 - 94

Published: Sept. 16, 2020

Language: Английский

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Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions

Neuron, Journal Year: 2019, Volume and Issue: 104(4), P. 810 - 824.e9

Published: Sept. 26, 2019

Language: Английский

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High-density multi-fiber photometry for studying large-scale brain circuit dynamics

Nature Methods, Journal Year: 2019, Volume and Issue: 16(6), P. 553 - 560

Published: May 13, 2019

Language: Английский

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The what, where and how of delay activity

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(8), P. 466 - 481

Published: May 13, 2019

Language: Английский

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Value-guided remapping of sensory cortex by lateral orbitofrontal cortex

Nature, Journal Year: 2020, Volume and Issue: 585(7824), P. 245 - 250

Published: Sept. 3, 2020

Language: Английский

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The mouse prefrontal cortex: Unity in diversity

Neuron, Journal Year: 2021, Volume and Issue: 109(12), P. 1925 - 1944

Published: April 23, 2021

Language: Английский

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Why is everyone talking about brain state?

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(7), P. 508 - 524

Published: May 8, 2023

The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.

Language: Английский

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Neuronal Circuits in Barrel Cortex for Whisker Sensory Perception

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(1), P. 353 - 415

Published: Aug. 20, 2020

The array of whiskers on the snout provides rodents with tactile sensory information relating to size, shape and texture objects in their immediate environment. Rodents can use detect stimuli, distinguish textures, locate navigate. Important aspects whisker sensation are thought result from neuronal computations somatosensory cortex (wS1). Each is individually represented somatotopic map wS1 by an anatomical unit named a ‘barrel’ (hence also called barrel cortex). This allows precise investigation processing context well-defined map. Here, we first review signaling pathways wS1, then discuss current understanding various types excitatory inhibitory neurons present within wS1. Different classes cells be defined according anatomical, electrophysiological molecular features. synaptic connectivity local microcircuits, as well long-range interactions impact neuromodulators, beginning understood. Recent technological progress has allowed cell-type-specific related activity during whisker-related behaviors. An important goal for future research obtain causal mechanistic how selected processed specific synaptically connected networks signaled downstream brain areas, thus contributing sensory-guided decision-making.

Language: Английский

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Separation of hemodynamic signals from GCaMP fluorescence measured with wide-field imaging

Journal of Neurophysiology, Journal Year: 2019, Volume and Issue: 123(1), P. 356 - 366

Published: Nov. 20, 2019

Wide-field calcium imaging is often used to measure brain dynamics in behaving mice. With a large field of view and high sampling rate, wide-field can monitor activity from several distant cortical areas simultaneously, revealing interactions. Interpretation images complicated, however, by the absorption light hemoglobin, which substantially affect measured fluorescence. One approach separating hemodynamics signals use multiwavelength backscatter recordings hemoglobin. Following this approach, we develop spatially detailed regression-based method estimate hemodynamics. This Spatial Model based on linear form Beer–Lambert relationship but fit at every pixel image does not rely estimation physical parameters. In awake mice three transgenic lines, offers improved separation changes GCaMP The improvement pronounced near blood vessels and, contrast with equations, remove vascular artifacts along sagittal midline general permits more accurate fluorescence-based determination neuronal across cortex. NEW & NOTEWORTHY paper addresses well-known strong source contamination calcium-imaging data: To guide researchers toward best separate hemodynamics, compare performance methods commonly mouse lines present novel regression model that outperforms other techniques consider.

Language: Английский

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