Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model DOI Creative Commons
Bastijn J.G. van den Boom, Alfredo Elhazaz-Fernandez,

Peter A. Rasmussen

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 4, 2023

Deep-brain stimulation (DBS) is an effective treatment for patients suffering from otherwise therapy-resistant psychiatric disorders, including obsessive-compulsive disorder. Modulation of cortico-striatal circuits has been suggested as a mechanism action. To gain mechanistic insight, we monitored neuronal activity in regions mouse model compulsive behavior, while systematically varying clinically-relevant parameters internal-capsule DBS. DBS showed dose-dependent effects on both brain and behavior: An increasing, yet balanced, number excited inhibited neurons was recruited, scattered throughout regions, excessive grooming decreased. Such recruitment did not alter basic function such resting-state activity, only occurred awake animals, indicating dependency network activity. In addition to these widespread effects, observed specific involvement the medial orbitofrontal cortex therapeutic outcomes, which corroborated by optogenetic stimulation. Together, our findings provide insight into how exerts its behaviors.

Language: Английский

Evolution of prefrontal cortex DOI Open Access
Todd M. Preuss,

Steven P. Wise

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 3 - 19

Published: Aug. 6, 2021

Language: Английский

Citations

168
Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective DOI Creative Commons
Ileana L. Hanganu‐Opatz, Thomas Klausberger, Torfi Sigurdsson

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1020 - 1036

Published: April 1, 2023

Language: Английский

Citations

51
Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders DOI Creative Commons
Rafael Naime Ruggiero, Matheus Teixeira Rossignoli, Danilo Benette Marques

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Oct. 11, 2021

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in executive and emotional functions. Neurophysiological studies have begun to unveil the dynamics of HPC-PFC interaction both immediate demands long-term adaptations. Disruptions functional connectivity can contribute neuropsychiatric symptoms observed mental illnesses neurological conditions, such as schizophrenia, depression, anxiety disorders, Alzheimer’s disease. Given dysfunctional physiology, it is crucial understand mechanisms that modulate communication. Two main regulate interactions are synaptic plasticity modulatory neurotransmission. Synaptic be investigated inducing potentiation or while spontaneous inferred by statistical dependencies between local field potentials regions. In turn, several neurotransmitters, acetylcholine, dopamine, serotonin, noradrenaline, endocannabinoids, fine-tuning connectivity. Despite experimental evidence, effects neuromodulation on neuronal from cellular behavioral levels not fully understood. current literature lacks review focuses neurotransmitter with activity. Here we reviewed showing systems long- short-term plasticity. We also looked for neuromodulatory oscillatory coordination. Finally, implications disruption cognition disorders. comprehensive overview these impairments could help better communication generate insights into etiology physiopathology clinical conditions.

Language: Английский

Citations

62
The role of the prefrontal cortex in social interactions of animal models and the implications for autism spectrum disorder DOI Creative Commons
Alok Nath Mohapatra, Shlomo Wagner

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: June 20, 2023

Social interaction is a complex behavior which requires the individual to integrate various internal processes, such as social motivation, recognition, salience, reward, and emotional state, well external cues informing of others' behavior, state rank. This phenotype susceptible disruption in humans affected by neurodevelopmental psychiatric disorders, including autism spectrum disorder (ASD). Multiple pieces convergent evidence collected from studies rodents suggest that prefrontal cortex (PFC) plays pivotal role interactions, serving hub for affiliation, empathy, hierarchy. Indeed, PFC circuitry results deficits symptomatic ASD. Here, we review this describe ethologically relevant tasks could be employed with rodent models study interactions. We also discuss linking pathologies associated Finally, address specific questions regarding mechanisms may result atypical interactions models, future should address.

Language: Английский

Citations

30
Single-neuron analysis of dendrites and axons reveals the network organization in mouse prefrontal cortex DOI
Le Gao, Sang Liu, Yanzhi Wang

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(6), P. 1111 - 1126

Published: May 22, 2023

Language: Английский

Citations

28
Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus DOI Creative Commons
Kyoko Tossell, Xiao Yu, Panagiotis Giannos

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1805 - 1819

Published: Sept. 21, 2023

The prefrontal cortex (PFC) enables mammals to respond situations, including internal states, with appropriate actions. One such state could be 'tiredness'. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFC

Language: Английский

Citations

27
Esr1+ hypothalamic-habenula neurons shape aversive states DOI Creative Commons
Daniela Calvigioni, János Fuzik, Pierre Le Merre

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(7), P. 1245 - 1255

Published: June 22, 2023

Excitatory projections from the lateral hypothalamic area (LHA) to habenula (LHb) drive aversive responses. We used patch-sequencing (Patch-seq) guided multimodal classification define structural and functional heterogeneity of LHA-LHb pathway. Our identified six glutamatergic neuron types with unique electrophysiological properties, molecular profiles projection patterns. found that genetically defined neurons signal distinct aspects emotional or naturalistic behaviors, such as estrogen receptor 1-expressing (Esr1+) induce aversion, whereas neuropeptide Y-expressing (Npy+) control rearing behavior. Repeated optogenetic Esr1+ induces a behaviorally persistent state, large-scale recordings showed region-specific neural representation signals in prelimbic region prefrontal cortex. further exposure unpredictable mild shocks induced sex-specific sensitivity develop stress state female mice, which was associated specific shift intrinsic properties bursting-type neurons. In summary, we describe diversity provide evidence for role aversion sexually dimorphic sensitivity.

Language: Английский

Citations

25
Aging disrupts the link between network centrality and functional properties of prefrontal neurons during memory-guided behavior DOI Creative Commons
Yadollah Ranjbar‐Slamloo,

Huee Ru Chong,

Tsukasa Kamigaki

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 16, 2025

The prefrontal cortex (PFC) is vital for higher cognitive functions and displays neuronal heterogeneity, with activity varying significantly across individual neurons. Using calcium imaging in the medial PFC (mPFC) of mice, we investigate whether differences degree centrality-a measure connectivity strength within local circuits-could explain this diversity its functional implications. In young adults, neurons high centrality, inferred from resting-state activity, exhibit reliable stable action-plan selectivity during memory-guided tasks, suggesting that closely linked to heterogeneity. This relationship, however, deteriorates middle-aged older mice. A computational model simulating age-related declines synaptic plasticity reproduces these results. centrality also predicts cross-modal selectivity, but predictive power diminishes age. Furthermore, are spatially clustered, a pattern fades aging. These findings reveal significant aging impact on network properties parallel spatial organization mPFC.

Language: Английский

Citations

1
Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation DOI Creative Commons

Lucie Dixsaut,

Johannes Gräff

eLife, Journal Year: 2022, Volume and Issue: 11

Published: July 15, 2022

Memory formation and storage rely on multiple interconnected brain areas, the contribution of which varies during memory consolidation. The medial prefrontal cortex, in particular prelimbic cortex (PL), was traditionally found to be involved remote storage, but recent evidence points toward its implication early consolidation as well. Nevertheless, inputs PL governing these dynamics remain unknown. Here, we first performed a brain-wide, rabies-based retrograde tracing screen engram cells activated contextual fear male mice identify relevant input regions. Next, assessed specific activity pattern across different phases consolidation, from encoding recall. Using projection-specific chemogenetic inhibition, then tested their functional role revealed hitherto unknown claustrum at encoding, insular Both further impacted how were reactivated recall, testifying relevance for establishing trace PL. Collectively, data spatiotemporal shift important thereby help refine working model formation.

Language: Английский

Citations

36
Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders DOI Creative Commons
Sanne M. Casello, Rodolfo J. Flores, Héctor E. Yarur

et al.

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 16

Published: June 21, 2022

Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, glial cell architecture function. To date, most what is known about neuropeptide action limited to subcortical brain structures tissue outside central system. Thus, there knowledge gap our understanding function within cortical circuits. In this review, we provide comprehensive overview families neuropeptides their cognate receptors that are expressed prefrontal cortex (PFC). Specifically, highlight dynorphin, enkephalin, corticotropin-releasing factor, cholecystokinin, somatostatin, Y, vasoactive intestinal peptide. Further, review implication circuit use as potential therapeutic targets. Together, summarizes established highlights unknowns modulation neural underlying while offering insights for future research. An increased emphasis area study necessary elucidate basic principles used circuits beyond fast excitatory inhibitory transmitters well consider components PFC target neurological disorders. Therefore, not only sheds light on importance studies, but also provides serve roadmap studies field.

Language: Английский

Citations

35