Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment DOI Open Access
Kathlyn J. Gan, Thomas C. Südhof

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(25), P. 12524 - 12533

Published: June 3, 2019

Significance Cognitive function decreases during aging, but the mechanisms involved remain unclear. Revolutionary recent studies revealed that introduction of blood from young mice into old increased cognitive abilities and synaptic connectivity, suggesting contains specific factors supporting function. Here, we asked whether is enriched in act directly on neurons to promote synapse formation. We show serum not indeed boosts formation cultured neurons, identify two factors, thrombospondin-4 SPARCL1, are mediate these effects. Thus, our experiments multiple connectivity between neurons.

Language: Английский

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair DOI
Brett J. Hilton, Jarred M. Griffin, James W. Fawcett

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(10), P. 649 - 667

Published: Aug. 20, 2024

Language: Английский

Citations

18
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus DOI Creative Commons

Mary O’Keeffe,

Sam A. Booker, Darren Walsh

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: 28(2), P. 268 - 279

Published: Jan. 6, 2025

Language: Английский

Citations

6
Local translation in neuronal processes DOI
Anne Biever, Paul G. Donlin‐Asp, Erin M. Schuman

et al.

Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 57, P. 141 - 148

Published: March 9, 2019

Language: Английский

Citations

114
Fluid Biomarkers for Synaptic Dysfunction and Loss DOI Creative Commons
Elena Camporesi, Johanna Nilsson, Ann Brinkmalm

et al.

Biomarker Insights, Journal Year: 2020, Volume and Issue: 15, P. 117727192095031 - 117727192095031

Published: Jan. 1, 2020

Synapses are the site for brain communication where information is transmitted between neurons and stored memory formation. Synaptic degeneration a global early pathogenic event in neurodegenerative disorders with reduced levels of pre- postsynaptic proteins being recognized as core feature Alzheimer’s disease (AD) pathophysiology. Together AD, other neurodevelopmental show altered synaptic homeostasis an important event, due to that, they commonly referred synaptopathies. The exact mechanisms synapse dysfunction different diseases not well understood their study would help understanding role degeneration, differences commonalities among them highlight candidate biomarkers specific disorders. assessment cerebrospinal fluid (CSF), which can reflect patients cognitive disorders, keen area interest. Substantial research efforts now directed toward investigation CSF pathology improve diagnosis at stage monitor clinical progression. In this review, we will first summarize pathological events that lead loss then discuss available data on established (eg, neurogranin, SNAP-25, synaptotagmin-1, GAP-43, α-syn) emerging vesicle glycoprotein 2A neuronal pentraxins) dysfunction, while highlighting possible utilities, specificity, technical challenges detection.

Language: Английский

Citations

109
Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment DOI Open Access
Kathlyn J. Gan, Thomas C. Südhof

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(25), P. 12524 - 12533

Published: June 3, 2019

Significance Cognitive function decreases during aging, but the mechanisms involved remain unclear. Revolutionary recent studies revealed that introduction of blood from young mice into old increased cognitive abilities and synaptic connectivity, suggesting contains specific factors supporting function. Here, we asked whether is enriched in act directly on neurons to promote synapse formation. We show serum not indeed boosts formation cultured neurons, identify two factors, thrombospondin-4 SPARCL1, are mediate these effects. Thus, our experiments multiple connectivity between neurons.

Language: Английский

Citations

103