The perceived control model of falling: developing a unified framework to understand and assess maladaptive fear of falling DOI Creative Commons
Toby J. Ellmers, Mark Wilson, Elmar Kal

et al.

Age and Ageing, Journal Year: 2023, Volume and Issue: 52(7)

Published: May 26, 2023

fear of falling is common in older adults and can have a profound influence on variety behaviours that increase fall risk. However, also potentially positive outcomes for certain individuals. Without progressing our understanding mechanisms underlying these contrasting outcomes, it difficult to clinically manage falling.this paper first summarises recent findings the topic falling, balance risk-including work highlighting protective effects fear. Specific focus placed describing how influences perceptual, cognitive motor process ways might either or reduce Finally, reports development validation new clinical tool be used assess maladaptive components falling.we present conceptual framework-the Perceived Control Model Falling-that describes specific through which The key advance identification perceived control over situations threaten one's as crucial factor mediating relationship between increased 4-item scale we develop-the Updated Falling Scale (UP-COF)-is valid reliable control.this conceptualisation (UP-COF) allows clinicians identify individuals whom likely risk, target processes such low control.

Language: Английский

Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits DOI
Kerry J. Ressler, Sabina Berretta, Vadim Y. Bolshakov

et al.

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(5), P. 273 - 288

Published: March 29, 2022

Language: Английский

Citations

265
The prefrontal cortex, pathological anxiety, and anxiety disorders DOI Open Access
Margaux M. Kenwood, Ned H. Kalin, Helen Barbas

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 260 - 275

Published: Aug. 16, 2021

Language: Английский

Citations

192
Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety DOI Creative Commons
T.A. Lovick, Hélio Zangrossi

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 31, 2021

Anxiety disorders are more prevalent in women than men. In the menstrual cycle introduces another variable; indeed, some conditions e.g., premenstrual syndrome, specific. Animal models of fear and anxiety, which form basis for research into drug treatments, have been developed almost exclusively, using males. There remains a paucity work females available literature presents confusing picture. One confound is estrous females, authors consider, but many do not. Importantly, there no accepted standardized criteria defining phase, important given rapidly changing hormonal profile during 4-day rodents. Moreover, since behavioral tests that involve learning component or consider extinction previously acquired association require several days to complete; outcome may depend on phase training as well test days. this article we responsiveness compared males number commonly used anxiety were male We conclude perform qualitatively similar manner most although be sex strain differences sensitivity. Tests based unconditioned threatening stimuli significantly influenced by with animals displaying increased late diestrus (similar women). utilize conditioned paradigms, appear less impacted cycle-related responding can still detected. Ethologically-relevant translational value females. However, even when behavior not detected, same outward response mediated different brain mechanisms. order progress basic field female psychiatry psychopharmacology, pressing need validate standardize experimental protocols animal anxiety-related states.

Language: Английский

Citations

155
Multidimensional processing in the amygdala DOI
Katalin M. Gothard

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(10), P. 565 - 575

Published: Aug. 24, 2020

Language: Английский

Citations

148
The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2545 - 2570

Published: May 27, 2022

Language: Английский

Citations

148
Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala DOI Creative Commons
Edmund T. Rolls

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 228(5), P. 1201 - 1257

Published: May 13, 2023

The orbitofrontal cortex and amygdala are involved in emotion motivation, but the relationship between these functions performed by brain structures is not clear. To address this, a unified theory of motivation described which motivational states instrumental goal-directed actions to obtain rewards or avoid punishers, emotional that elicited when reward punisher received. This greatly simplifies our understanding for same set genes associated systems can define primary unlearned punishers such as sweet taste pain. Recent evidence on connectivity human indicates value experienced with outputs cortical regions including those language, key region depression changes motivation. has weak effective back humans, implicated brainstem-mediated responses stimuli freezing autonomic activity, rather than declarative emotion. anterior cingulate learning rewards, ventromedial prefrontal providing goals navigation reward-related effects memory consolidation mediated partly via cholinergic system.

Language: Английский

Citations

134
A distributed fMRI-based signature for the subjective experience of fear DOI Creative Commons
Feng Zhou, Weihua Zhao, Ziyu Qi

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 17, 2021

The specific neural systems underlying the subjective feeling of fear are debated in affective neuroscience. Here, we combine functional MRI with machine learning to identify and evaluate a sensitive generalizable signature predictive momentary self-reported experience across discovery (n = 67), validation 20) generalization 31) cohorts. We systematically demonstrate that accurate prediction crucially requires distributed brain systems, important contributions from cortical (e.g., prefrontal, midcingulate insular cortices) subcortical thalamus, periaqueductal gray, basal forebrain amygdala) regions. further representation is distinguishable conditioned threat general negative affect. Overall, our findings suggest fear, which exhibits distinct some other aversive states, encoded rather than isolated 'fear centers'.

Language: Английский

Citations

117
Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation DOI Creative Commons
Sophie Bagur, Julie M. Lefort, Marie Lacroix

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 10, 2021

Brain-body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of respiratory-related oscillation, via bulbectomy or optogenetic perturbation OB, reduces freezing. Behavioural modelling shows is due a specific reduction maintenance without impacting its initiation, thus dissociating these two phenomena. dmPFC LFP and firing patterns support region's function maintenance. particular, population analysis reveals network activity tracks power dynamics reaches stable state at peak lasts until termination. These results provide potential mechanism functional role for bodily feedback therefore shed light on historical James-Cannon debate.

Language: Английский

Citations

113
A new science of emotion: implications for functional neurological disorder DOI Creative Commons
Johannes Jungilligens, Sara Paredes-Echeverri, Stoyan Popkirov

et al.

Brain, Journal Year: 2022, Volume and Issue: 145(8), P. 2648 - 2663

Published: June 2, 2022

Abstract Functional neurological disorder reflects impairments in brain networks leading to distressing motor, sensory and/or cognitive symptoms that demonstrate positive clinical signs on examination incongruent with other conditions. A central issue historical and contemporary formulations of functional has been the mechanistic aetiological role emotions. However, debate mostly omitted fundamental questions about nature emotions first place. In this perspective article, we outline a set relevant working principles (e.g. allostasis, predictive processing, interoception affect), followed by focused review theory constructed emotion introduce new understanding what are. Building theoretical framework, formulate how altered category construction can be an integral component pathophysiology related somatic symptoms. doing so, address several themes for field including: (i) energy regulation process relate symptom generation, including revisiting alexithymia, ‘panic attack without panic’, dissociation, insecure attachment influential life experiences; (ii) re-interpret select neurobiological research findings cohorts through lens illustrate its potential relevance; (iii) discuss therapeutic implications. While continue support is mechanistically aetiologically heterogenous, consideration relates generation maintenance offers integrated viewpoint cuts across neurology, psychiatry, psychology cognitive-affective neuroscience.

Language: Английский

Citations

105
Emotional contagion and prosocial behavior in rodents DOI Creative Commons
Christian Keysers, Ewelina Knapska, Marta A. Moita

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(8), P. 688 - 706

Published: June 3, 2022

Empathy is critical to adjusting our behavior the state of others. The past decade dramatically deepened understanding biological origin this capacity. We now understand that rodents robustly show emotional contagion for distress others via neural structures homologous those involved in human empathy. Their propensity approach strengthens effect. Although can also learn favor behaviors benefit overlapping with contagion, they do so less reliably and more selectively. Together, suggests evolution selected mechanisms prepare animals dangers by using as sentinels. Such shared emotions additionally can, under certain circumstances, promote prosocial behavior.

Language: Английский

Citations

90