Functional boundaries in the human cerebellum revealed by a multi-domain task battery

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(8), P. 1371 - 1378

Published: July 8, 2019

Language: Английский

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The Theory and Neuroscience of Cerebellar Cognition

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 42(1), P. 337 - 364

Published: April 2, 2019

Cerebellar neuroscience has undergone a paradigm shift. The theories of the universal cerebellar transform and dysmetria thought principles organization cerebral cortical connections, together with neuroanatomical, brain imaging, clinical observations, have recontextualized cerebellum as critical node in distributed neural circuits subserving behavior. framework for cognition stems from identification three cognitive representations posterior lobe, which are interconnected association areas distinct primary secondary sensorimotor linked spinal cord motor areas. Lesions anterior lobe produce movement, syndrome. cognitive-emotional emotion, affective/Schmahmann notion that modulates emotion same way it control advances understanding mechanisms opens new therapeutic opportunities behavioral neurology neuropsychiatry.

Language: Английский

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A somato-cognitive action network alternates with effector regions in motor cortex

Nature, Journal Year: 2023, Volume and Issue: 617(7960), P. 351 - 359

Published: April 19, 2023

Abstract Motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down the precentral gyrus from foot face representations 1,2 , despite evidence for concentric functional zones 3 and maps of complex actions 4 . Here, using precision magnetic resonance imaging (fMRI) methods, we find that classic is interrupted by regions with distinct connectivity, structure function, alternating effector-specific (foot, hand mouth) areas. These inter-effector exhibit decreased cortical thickness strong connectivity each other, as well cingulo-opercular network (CON), critical action 5 physiological control 6 arousal 7 errors 8 pain 9 This interdigitation control-linked motor effector was verified in three largest fMRI datasets. Macaque pediatric (newborn, infant child) suggested cross-species homologues developmental precursors system. A battery tasks documented somatotopies, separated CON-linked regions. The inter-effectors lacked movement specificity co-activated during planning (coordination hands feet) axial body (such abdomen or eyebrows). results, together previous studies demonstrating stimulation-evoked internal organs 10 such adrenal medulla, suggest M1 punctuated system whole-body planning, somato-cognitive (SCAN). In M1, two parallel systems intertwine, forming an integrate–isolate pattern: isolating fine SCAN integrating goals, physiology movement.

Language: Английский

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Emerging connections between cerebellar development, behaviour and complex brain disorders

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(5), P. 298 - 313

Published: March 28, 2019

Language: Английский

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Universal Transform or Multiple Functionality? Understanding the Contribution of the Human Cerebellum across Task Domains

Neuron, Journal Year: 2019, Volume and Issue: 102(5), P. 918 - 928

Published: June 1, 2019

Language: Английский

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Individual Variation in Functional Topography of Association Networks in Youth

Neuron, Journal Year: 2020, Volume and Issue: 106(2), P. 340 - 353.e8

Published: Feb. 19, 2020

Language: Английский

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Trait-like variants in human functional brain networks

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(45), P. 22851 - 22861

Published: Oct. 14, 2019

Resting-state functional magnetic resonance imaging (fMRI) has provided converging descriptions of group-level brain organization. Recent work revealed that networks identified in individuals contain local features differ from the description. We define these as network variants. Building on studies, we ask whether distributions variants reflect stable, trait-like differences Across several datasets highly-sampled show 1) are highly stable within individuals, 2) found characteristic locations and associate with across large groups, 3) task-evoked signals demonstrate a link to variation, 4) cluster into subgroups basis variant characteristics related behavior. These results suggest may trait-like, functionally relevant individual

Language: Английский

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A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum

NeuroImage, Journal Year: 2019, Volume and Issue: 206, P. 116290 - 116290

Published: Oct. 18, 2019

An important aspect of network-based analysis is robust node definition. This issue critical for functional brain network analyses, as poor choice can lead to spurious findings and misleading inferences about organization. Two sets nodes from our group are well represented in the literature: (1) 264 volumetric regions interest (ROIs) reported Power et al., 2011, (2) 333 cortical surface parcels Gordon 2016. However, subcortical cerebellar structures either incompletely captured or missing these ROI sets. Therefore, properties organization involving subcortex cerebellum may be underappreciated thus far. Here, we apply a winner-take-all partitioning method resting-state fMRI data generate novel functionally-constrained ROIs thalamus, basal ganglia, amygdala, hippocampus, cerebellum. We validate three datasets using several criteria, including agreement with existing literature anatomical atlases. Further, demonstrate that combining established recapitulates extends previously described new set made publicly available general use, full list MNI coordinates labels.

Language: Английский

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Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

Neuron, Journal Year: 2019, Volume and Issue: 105(4), P. 742 - 758.e6

Published: Dec. 10, 2019

Language: Английский

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Plasticity and Spontaneous Activity Pulses in Disused Human Brain Circuits

Neuron, Journal Year: 2020, Volume and Issue: 107(3), P. 580 - 589.e6

Published: June 16, 2020

Language: Английский

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