A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation DOI Creative Commons
Hannah Twarkowski,

Victor Steininger,

Min Jae Kim

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Feb. 22, 2022

Memories encoded in the dentate gyrus (DG) ‒ CA3 circuit of hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although parvalbumin inhibitory neurons (PV INs) orchestrate hippocampal-cortical communication, we know less about PV INs or DG principal neuron IN mechanisms that contribute evolution ensembles during memory Using viral genetics selectively mimic and boost an endogenous learning-dependent mechanism, cell recruitment feed-forward inhibition (FFI) CA3, combination with longitudinal vivo calcium imaging, demonstrate FFI facilitates formation maintenance context-associated neuronal CA1. Increasing promoted context specificity ACC over time enhanced long-term contextual fear memory. In LFP recordings mice increased identified sharp-wave ripple spindle coupling as a potential network mechanism facilitating Our findings illuminate how dictates ensemble properties consolidation suggest teacher-like function hippocampal stabilization re-organization cortical representations.

Language: Английский

If deep learning is the answer, what is the question? DOI
Andrew Saxe, Stephanie Nelli, Christopher Summerfield

et al.

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 22(1), P. 55 - 67

Published: Nov. 16, 2020

Language: Английский

Citations

343
Prediction and memory: A predictive coding account DOI Creative Commons
Helen C. Barron, Ryszard Auksztulewicz, Karl Friston

et al.

Progress in Neurobiology, Journal Year: 2020, Volume and Issue: 192, P. 101821 - 101821

Published: May 21, 2020

The hippocampus is crucial for episodic memory, but it also involved in online prediction. Evidence suggests that a unitary hippocampal code underlies both memory and predictive processing, yet within coding framework the hippocampal-neocortical interactions accompany these two phenomena are distinct opposing. Namely, during recall, thought to exert an excitatory influence on neocortex, reinstate activity patterns across cortical circuits. This contrasts with empirical theoretical work where descending predictions suppress prediction errors 'explain away' ascending inputs via inhibition. In this hypothesis piece, we attempt dissolve previously overlooked dialectic. We consider how may facilitate respectively, by inhibiting neocortical or increasing their gain. propose processing modes depend upon neuromodulatory gain (or precision) ascribed error units. Within framework, recall cast as arising from fictive furnish training signals optimise generative models of world, absence sensory data.

Language: Английский

Citations

180
Mechanisms of memory under stress DOI Creative Commons
Lars Schwabe, Erno J. Hermans, Marian Joëls

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(9), P. 1450 - 1467

Published: March 21, 2022

Language: Английский

Citations

120
The Neuropsychology of Anxiety DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Language: Английский

Citations

73
Lack of context modulation in human single neuron responses in the medial temporal lobe DOI Creative Commons
Hernán G. Rey, Theofanis I. Panagiotaropoulos,

Lorenzo Gutierrez

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115218 - 115218

Published: Jan. 1, 2025

Language: Английский

Citations

2
Integration and differentiation of hippocampal memory traces DOI
Iva K. Brunec, Jessica Robin, Rosanna K. Olsen

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 118, P. 196 - 208

Published: July 23, 2020

Language: Английский

Citations

102
Ventral Hippocampal-Prefrontal Interaction Affects Social Behavior via Parvalbumin Positive Neurons in the Medial Prefrontal Cortex DOI Creative Commons
Qingtao Sun, Xiangning Li, Anan Li

et al.

iScience, Journal Year: 2020, Volume and Issue: 23(3), P. 100894 - 100894

Published: Feb. 11, 2020

Ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC) are both critical regions for social behaviors. However, how their interactions affect behavior is not well understood. By viral tracing, optogenetics, chemogenetics, fiber photometry, we demonstrated that inhibition of vHIP or direct projections from to mPFC impaired memory expression. Via rabies retrograde found all three major GABAergic neurons in received inputs vHIP. Activation parvalbumin positive (PV+) but somatostatin (SST+) can rescue the impairment caused by inhibition. Furthermore, photometry results behaviors preferentially recruited PV+ hippocampal disrupted activity during interactions. These revealed a new mechanism regulate complementarity with existing neural circuitry mechanism.

Language: Английский

Citations

87
Regulation of circuit organization and function through inhibitory synaptic plasticity DOI
Yue Kris Wu, Christoph Miehl, Julijana Gjorgjieva

et al.

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(12), P. 884 - 898

Published: Oct. 28, 2022

Language: Английский

Citations

59
A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement DOI Open Access
Hamed Ekhtiari, Peyman Ghobadi‐Azbari, Axel Thielscher

et al.

Nature Protocols, Journal Year: 2022, Volume and Issue: 17(3), P. 596 - 617

Published: Feb. 4, 2022

Language: Английский

Citations

39
Extra-hippocampal contributions to pattern separation DOI Creative Commons
Tarek Amer, Lila Davachi

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 27, 2023

Pattern separation, or the process by which highly similar stimuli experiences in memory are represented non-overlapping neural ensembles, has typically been ascribed to processes supported hippocampus. Converging evidence from a wide range of studies, however, suggests that pattern separation is multistage network brain regions. Based on this evidence, considered together with related findings interference resolution literature, we propose 'cortico-hippocampal separation' (CHiPS) framework, asserts regions involved cognitive control play significant role separation. Particularly, these may contribute (1) resolving sensory project hippocampus, thus regulating its cortical input, (2) directly modulating hippocampal accordance task demands. Considering recent interest how operations modulated goal states likely and regulated extra-hippocampal regions, argue similarly neocortical-hippocampal interactions.

Language: Английский

Citations

38