Neural mechanisms of aggression across species

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(11), P. 1317 - 1328

Published: Oct. 12, 2020

Language: Английский

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Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice

Nature, Journal Year: 2020, Volume and Issue: 589(7841), P. 258 - 263

Published: Dec. 2, 2020

Language: Английский

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Breathing Rhythm and Pattern and Their Influence on Emotion

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 223 - 247

Published: March 9, 2022

Breathing is a vital rhythmic motor behavior with surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies complex neural control system, central pattern generator (bCPG), that exhibits diverse operational modes to regulate gas exchange coordinate an array behaviors. In this review, we focus selected advances in our understanding bCPG. At core bCPG preBötzinger (preBötC), which drives inspiratory rhythm via unexpectedly sophisticated emergent mechanism. Synchronization dynamics underlying preBötC rhythmogenesis imbue system robustness lability. These are modulated by inputs from throughout generate rhythmic, patterned activity widely distributed. connectivity emerging literature support link between breathing, emotion, cognition becoming experimentally tractable. bring great potential for elucidating function dysfunction other mammalian circuits.

Language: Английский

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Neural Circuits for Emotion

Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 211 - 231

Published: March 14, 2023

Emotions are fundamental to our experience and behavior, affecting motivating all aspects of lives. Scientists various disciplines have been fascinated by emotions for centuries, yet even today vigorous debates abound about how define best study their neural underpinnings. Defining from an evolutionary perspective acknowledging important functional roles in supporting survival allows the emotion states diverse species. This approach enables taking advantage modern tools behavioral, systems, circuit neurosciences, allowing precise dissection mechanisms behavior underlying processes model organisms. Here we review findings processing across species try identify points convergence as well next steps pursuit understanding emerge activity.

Language: Английский

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Mouse and rat ultrasonic vocalizations in neuroscience and neuropharmacology: State of the art and future applications

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 57(12), P. 2062 - 2096

Published: March 9, 2023

Mice and rats emit ultrasonic vocalizations (USVs), which may express their arousal emotional states, to communicate with each other. There is continued scientific effort better understand the functions of USVs as a central element rodent behavioral repertoire. However, studying not only important because ethological relevance, but also they are widely applied readout in various fields biomedical research. In mice rats, large number experimental models brain disorders exist emission these can provide valuable information about health status animals effectiveness possible interventions, both environmental pharmacological. This review (i) provides an updated overview contexts calling behaviour has particularly high translational value, (ii) gives some examples novel approaches tools used for analysis combining qualitative quantitative methods. The relevance age sex differences well importance longitudinal evaluations non-calling discussed. Finally, assessing communicative impact receiver, that is, through playback studies, highlighted.

Language: Английский

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Brainstem control of vocalization and its coordination with respiration

Science, Journal Year: 2024, Volume and Issue: 383(6687)

Published: March 7, 2024

Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific premotor neurons located retroambiguus nucleus (RAm VOC ) adult mice as being both necessary and sufficient for driving vocal cord closure eliciting mouse ultrasonic vocalizations (USVs). The duration RAm activation can determine lengths USV syllables concurrent expiration periods, impact depending respiration phases. receive inhibition from preBötzinger complex, inspiration needs override -mediated closure. Ablating inhibitory synapses compromised this gating adduction, resulting discoordination vocalization Our study reveals circuits production vocal-respiratory coordination.

Language: Английский

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A humanized NOVA1 splicing factor alters mouse vocal communications

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 18, 2025

Abstract NOVA1, a neuronal RNA-binding protein expressed in the central nervous system, is essential for survival mice and normal development humans. A single amino acid change (I197V) NOVA1’s second RNA binding domain unique to modern To study its physiological effects, we generated carrying human-specific I197V variant ( Nova1 hu/hu ) analyzed molecular behavioral consequences. While substitution had minimal impact on capacity, it led specific effects alternative splicing, CLIP revealed multiple peaks mouse brain transcripts involved vocalization. These findings were associated with differences vocalization patterns as pups adults. Our suggest that this NOVA1 may have been part of an ancient evolutionary selective sweep common ancestral population Homo sapiens , possibly contributing spoken language through differential regulation during development.

Language: Английский

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The neurobiology of innate, volitional and learned vocalizations in mammals and birds

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2019, Volume and Issue: 375(1789), P. 20190054 - 20190054

Published: Nov. 18, 2019

Vocalization is an ancient vertebrate trait essential to many forms of communication, ranging from courtship calls free verse. Vocalizations may be entirely innate and evoked by sexual cues or emotional state, as with types made in primates, rodents birds; volitional, that, following extensive training, can arbitrary sensory non-human primates corvid songbirds; learned, acoustically flexible complex, human speech the songs oscine songbirds. This review compares contrasts neural mechanisms underlying innate, volitional learned vocalizations, emphasis on functional studies comparison reveals both highly conserved convergent vocal production these different groups, despite their often vast phylogenetic separation. similarity central for presents experimentalists useful avenues gaining detailed mechanistic insight into how vocalizations are employed social signalling, they modified through experience yield new repertoires customized individual's group. article part theme issue ‘What animal communication teach us about language?’

Language: Английский

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Ultrasonic signals associated with different types of social behavior of mice

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(3), P. 411 - 422

Published: Feb. 17, 2020

Language: Английский

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Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit

Neuron, Journal Year: 2020, Volume and Issue: 106(4), P. 637 - 648.e6

Published: March 11, 2020

Language: Английский

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