Independent inhibitory control mechanisms for aggressive motivation and action DOI
Tomohito Minakuchi, Eartha Mae Guthman,

Preeta Acharya

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(4), P. 702 - 715

Published: Feb. 12, 2024

Language: Английский

Large-scale neural recordings call for new insights to link brain and behavior DOI
Anne E. Urai, Brent Doiron, Andrew M. Leifer

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(1), P. 11 - 19

Published: Jan. 1, 2022

Language: Английский

Citations

255
The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2545 - 2570

Published: May 27, 2022

Language: Английский

Citations

142
Gene regulation by gonadal hormone receptors underlies brain sex differences DOI Creative Commons
Bruno Gegenhuber, Melody V. Wu, Robert Bronstein

et al.

Nature, Journal Year: 2022, Volume and Issue: 606(7912), P. 153 - 159

Published: May 4, 2022

Abstract Oestradiol establishes neural sex differences in many vertebrates 1–3 and modulates mood, behaviour energy balance adulthood 4–8 . In the canonical pathway, oestradiol exerts its effects through transcription factor oestrogen receptor-α (ERα) 9 Although ERα has been extensively characterized breast cancer, neuronal targets of ERα, their involvement brain differences, remain largely unknown. Here we generate a comprehensive map genomic ERα-binding sites sexually dimorphic circuit that mediates social behaviours. We conclude orchestrates sexual differentiation mouse two mechanisms: establishing male-biased neuron types activating sustained gene expression program. Collectively, our findings reveal are defined by hormonal activation steroid receptors. The molecular identify may underlie on development, disease.

Language: Английский

Citations

141
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior DOI Creative Commons
Joseph R. Knoedler,

Sayaka Inoue,

Daniel W. Bayless

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(4), P. 654 - 671.e22

Published: Jan. 21, 2022

Language: Английский

Citations

112
Make war not love: The neural substrate underlying a state-dependent switch in female social behavior DOI Creative Commons
Mengyu Liu, Dong-Wook Kim, Hongkui Zeng

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(5), P. 841 - 856.e6

Published: Jan. 3, 2022

Female mice exhibit opposing social behaviors toward males depending on their reproductive state: virgins display sexual receptivity (lordosis behavior), while lactating mothers attack. How a change in state produces qualitative switch behavioral response to the same conspecific stimulus is unknown. Using single-cell RNA-seq, we identify two distinct subtypes of estrogen receptor-1-positive neurons ventrolateral subdivision female ventromedial hypothalamus (VMHvl) and demonstrate that they causally control aggressiveness mothers, respectively. Between- within-subject bulk-calcium recordings from each subtype reveal aggression-specific cells acquire an increased responsiveness cues during transition virginity maternity, mating-specific population appears unchanged. These results reproductive-state-dependent changes relative activity transcriptomically neural can underlie categorical switches behavior associated with physiological changes.

Language: Английский

Citations

96
A nutrient-specific gut hormone arbitrates between courtship and feeding DOI
Hui‐Hao Lin, Meihua Christina Kuang, Imran Hossain

et al.

Nature, Journal Year: 2022, Volume and Issue: 602(7898), P. 632 - 638

Published: Feb. 9, 2022

Language: Английский

Citations

80
An approximate line attractor in the hypothalamus encodes an aggressive state DOI Creative Commons
Aditya Nair, Tomomi Karigo, Bin Yang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(1), P. 178 - 193.e15

Published: Jan. 1, 2023

The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA VMHvl, respectively. Here, we perform dynamical systems modeling population activity in these nuclei during behaviors. In unsupervised analysis identified a dominant dimension neural with large time constant (>50 s), generating an approximate line attractor state space. Progression the trajectory along this was correlated escalation agonistic behavior, suggesting that it may encode scalable aggressiveness. Consistent this, individual differences magnitude integration were strongly contrast, attractors not observed mating; instead, neurons fast dynamics tuned to actions. Thus, different hypothalamic employ distinct codes represent similar

Language: Английский

Citations

76
Hypothalamic control of innate social behaviors DOI
Long Mei, Takuya Osakada, Dayu Lin

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6669), P. 399 - 404

Published: Oct. 26, 2023

Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals species survival thus supported by hardwired neural circuits. The behavior control column (RBCC), which comprises medial preoptic nucleus (MPN), ventrolateral part ventromedial hypothalamus (VMHvl), ventral premammillary (PMv), is essential for all social behaviors. RBCC integrates diverse hormonal metabolic cues adjusts an animal's physical activity, hence chance encounters. further engages mesolimbic dopamine system maintain interest reinforces actions that time-locked with We propose brainstem form a dual-control generating moment-to-moment actions. This Review summarizes recent progress regarding identities cells their pathways drive different aspects

Language: Английский

Citations

45
A neural circuit for male sexual behavior and reward DOI Creative Commons

Daniel W. Bayless,

Chung-ha O. Davis, Renzhi Yang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(18), P. 3862 - 3881.e28

Published: Aug. 1, 2023

Male sexual behavior is innate and rewarding. Despite its centrality to reproduction, a molecularly specified neural circuit governing male reward remains be characterized. We have discovered developmentally wired necessary sufficient for mating. This connects chemosensory input BNSTprTac1 neurons, which innervate POATacr1 neurons that project centers regulating motor output reward. Epistasis studies demonstrate are upstream of BNSTprTac1-released substance P following mate recognition potentiates activation through Tacr1 initiate Experimental triggers mating, even in sexually satiated males, it rewarding, eliciting dopamine release self-stimulation these cells. Together, we uncovered governs the key aspects behavior: displays, drive,

Language: Английский

Citations

43
Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy DOI
Rachida Ammari, Francesco Monaca,

Mingran Cao

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6666), P. 76 - 81

Published: Oct. 6, 2023

During pregnancy, physiological adaptations prepare the female body for challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such can occur as early during but how pregnancy hormones remodel parenting circuits to instruct preparatory changes remains unknown. We found that action estradiol and progesterone on galanin (Gal)–expressing neurons in mouse medial preoptic area (MPOA) is critical pregnancy-induced parental behavior. Whereas silences MPOA Gal paradoxically increases their excitability, permanently rewires this circuit node by promoting dendritic spine formation recruitment excitatory synaptic inputs. This -specific neural remodeling sparsens population activity vivo results persistently stronger, more selective responses pup stimuli. Pregnancy thus anticipation future need.

Language: Английский

Citations

43