Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning DOI Creative Commons
James Peak, Billy Chieng, Genevra Hart

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 20, 2020

The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action; however, the role of direct (dSPN) and indirect (iSPN) spiny projection neurons in pDMS such actions remains unclear. In this series experiments, we examined SPNs action rats found that whereas dSPNs were critical learning energizing learned response, iSPNs involved updating to support response flexibility. Instrumental training elevated expression plasticity marker Zif268 only, chemogenetic suppression dSPN activity during prevented learning. Unilateral optogenetic inhibition induced an ipsilateral bias performance. contrast, although initial was unaffected by iSPN manipulations, iSPNs, but not dSPNs, impaired attenuated flexibility after changes action-outcome contingency.

Language: Английский

The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids DOI Creative Commons
Isaac Oluwatobi Akefe,

Saber H. Saber,

Benjamin J. Matthews

et al.

The EMBO Journal, Journal Year: 2024, Volume and Issue: 43(4), P. 533 - 567

Published: Feb. 5, 2024

Abstract The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning memory, but the mechanisms through which activity affects brain’s lipid landscape remain largely unexplored. levels saturated FFAs, particularly myristic (C14:0), strongly increase during stimulation memory acquisition, suggesting involvement phospholipase A1 (PLA1) synaptic plasticity. Here, we show that genetic ablation PLA1 isoform DDHD2 mice dramatically reduces FFA responses to acquisition across brain. Furthermore, loss also decreases performance reward-based spatial models prior development neuromuscular deficits mirror human spastic paraplegia. Via pulldown-mass spectrometry analyses, find binds key protein STXBP1. Using STXBP1/2 knockout neurosecretory cells haploinsufficient STXBP1 +/− mouse model early infantile encephalopathy associated with intellectual disability motor dysfunction, controls targeting plasma membrane generation FFAs These findings suggest roles for metabolism processes plasticity, learning, memory.

Language: Английский

Citations

10
A dual-pathway architecture for stress to disrupt agency and promote habit DOI
Jacqueline Giovanniello,

Natalie Paredes,

Anna Wiener

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

1
Making habits measurable beyond what they are not: A focus on associative dual-process models DOI
Poppy Watson, Claire O’Callaghan, Iain Perkes

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104869 - 104869

Published: Sept. 13, 2022

Language: Английский

Citations

38
Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice DOI Creative Commons
Tadaaki Nishioka,

Suthinee Attachaipanich,

Kosuke Hamaguchi

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 21, 2023

Abstract Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also inhibit, order to achieve specific goal. The encoding of such cue-outcome associations, as well performance cue-guided choice behavior, is thought involve dopamine D1 D2 receptor-expressing medium spiny neurons (D1-/D2-MSNs) nucleus accumbens (NAc). Here, using visual discrimination task male mice, assessed NAc D1-/D2-MSNs inhibition inappropriate responding. Cell-type neuronal silencing in-vivo imaging revealed D2-MSNs contribute inhibiting responses, with activation following response errors playing an important optimizing future behavior. Our findings indicate that error-signaling by contributes ability use inhibit

Language: Английский

Citations

20
Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning DOI Creative Commons
James Peak, Billy Chieng, Genevra Hart

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 20, 2020

The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action; however, the role of direct (dSPN) and indirect (iSPN) spiny projection neurons in pDMS such actions remains unclear. In this series experiments, we examined SPNs action rats found that whereas dSPNs were critical learning energizing learned response, iSPNs involved updating to support response flexibility. Instrumental training elevated expression plasticity marker Zif268 only, chemogenetic suppression dSPN activity during prevented learning. Unilateral optogenetic inhibition induced an ipsilateral bias performance. contrast, although initial was unaffected by iSPN manipulations, iSPNs, but not dSPNs, impaired attenuated flexibility after changes action-outcome contingency.

Language: Английский

Citations

45