Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells DOI
Ming Li, Xueke Yang,

Jian Yang

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(18), P. 3192 - 3210.e6

Published: July 19, 2024

Language: Английский

A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction DOI
Ozge Gunduz‐Cinar,

Laura I. Castillo,

Maya Xia

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(19), P. 3053 - 3067.e10

Published: July 21, 2023

Language: Английский

Citations

29
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice DOI
Sylvie L. Lesuis,

Sungmo Park,

Aijm Van Der Hoorn

et al.

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

12
The role of glial cells in mental illness: a systematic review on astroglia and microglia as potential players in schizophrenia and its cognitive and emotional aspects DOI Creative Commons
Daniela Laricchiuta,

Martina Papi,

Davide Decandia

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 14, 2024

Schizophrenia is a complex and severe mental disorder that affects approximately 1% of the global population. It characterized by wide range symptoms, including delusions, hallucinations, disorganized speech behavior, cognitive impairment. Recent research has suggested immune system dysregulation may play significant role in pathogenesis schizophrenia, glial cells, such as astroglia microglia known to be involved neuroinflammation regulation, have emerged potential players this process. The aim systematic review summarize hallmarks choosing cellular candidate microglia, focusing also on disease-associated psychological (cognitive emotional) changes. We conducted following Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines. searched PubMed, Scopus, Web Science articles investigated differences patients with published last 5 years. present indicates changes density, morphology, functioning development schizophrenia. alterations contribute schizophrenia dysregulating neurotransmission responses, worsening capabilities. interplay astroglial microglial activation, genetic/epigenetic variations, assessments underscores intricate relationship between biological mechanisms, symptomatology,

Language: Английский

Citations

11
Neuronal theta oscillation of hippocampal ensemble and memory function DOI
Lin Sun,

Lihua Bao

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: 481, P. 115429 - 115429

Published: Jan. 10, 2025

Language: Английский

Citations

1
Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus DOI
Mayumi Watanabe, Akira Uematsu, Joshua P. Johansen

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

1
Neural substrates of appetitive and aversive prediction error DOI
Mihaela D Iordanova, Joanna Oi-Yue Yau, Michael A. McDannald

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 123, P. 337 - 351

Published: Jan. 14, 2021

Language: Английский

Citations

51
Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways DOI Creative Commons
Qi Wang,

Jia‐Jie Zhu,

Lizhao Wang

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 21, 2022

Abstract Threat and extinction memories are crucial for organisms’ survival in changing environments. These believed to be encoded by separate ensembles of neurons the brain, but their whereabouts remain elusive. Using an auditory fear-conditioning paradigm male mice, here we discovered that two distinct projection neuron subpopulations physical proximity within insular cortex (IC), targeting central amygdala (CeA) nucleus accumbens (NAc), respectively, encode fear memories. Reciprocal intracortical inhibition these IC gates emergence either or memory. rabies-virus-assisted tracing, found IC-NAc preferentially innervated intercortical inputs from orbitofrontal (OFC), specifically enhancing override results demonstrate serves as operation node harboring decipher memory under top-down executive control OFC.

Language: Английский

Citations

38
Single‐Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury DOI Creative Commons
Yingwu Shi, Xun Wu, Jinpeng Zhou

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(7)

Published: Jan. 17, 2022

Abstract Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear defining characteristic of PTSD, and the amygdala considered main region to process fear. The mechanism by which involved in conditioning after TBI still unclear. Using single‐nucleus RNA sequencing (snRNA‐seq), transcriptional changes cells are investigated. In total, 72 328 nuclei obtained from sham groups. 7 cell types, analysis differentially expressed genes (DEGs) reveals widespread each type identified. vivo experiments, it demonstrated that Decorin (Dcn) expression excitatory neurons significantly increased TBI, Dcn knockout mitigates TBI‐associated conditioning. Of note, this effect caused Dcn‐mediated decrease perineuronal nets (PNNs), affect glutamate‐ γ ‐aminobutyric acid balance amygdala. Finally, results suggest functions interacting with collagen VI α 3 (Col6a3). Consequently, findings reveal different types provide direct evidence relieves regulating PNNs.

Language: Английский

Citations

31
Differential coding of absolute and relative aversive value in the Drosophila brain DOI Creative Commons
María Eugenia Villar,

Miguel Pavão-Delgado,

Marie Amigo

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(21), P. 4576 - 4592.e5

Published: Sept. 13, 2022

Animals use prior experience to assign absolute (good or bad) and relative (better worse) value new experience. These learned values guide appropriate later decision making. Even though our understanding of how the valuation system computes is relatively advanced, mechanistic underpinnings are unclear. Here, we uncover mechanisms aversive in Drosophila. Three types punishment-sensitive dopaminergic neurons (DANs) respond differently electric shock intensity. During learning, these DANs drive intensity-scaled plasticity at their respective mushroom body output neuron (MBON) connections code value. In contrast, by comparing current previous experiences, MBON-DAN network can using specific recruiting a subtype reward-coding DANs. Behavioral physiological experiments revealed that DAN assigns "better than" lesser two experiences. This study therefore highlights appetitive-aversive interactions within MB compare sequential experiences learn

Language: Английский

Citations

29
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala DOI Creative Commons
Robin Nguyen,

Konstantinos Koukoutselos,

Thomas Forro

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(22)

Published: May 31, 2023

Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it poorly understood whether representations are imbued with emotional values support selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during formation of cued fear extinction memory. During when CS acquire safety properties, found CS-related activity vH reactivated sleep consolidation was strengthened upon retrieval. Moreover, facilitated context exhibited precise coding its affective zones. Last, these patterns along were dependent on glutamatergic transmission BLA learning. Thus, relies stimulus instructed BLA.

Language: Английский

Citations

22