Nature Metabolism,
Journal Year:
2024,
Volume and Issue:
6(11), P. 2082 - 2099
Published: Nov. 4, 2024
Vascular
pathology
is
associated
with
cognitive
impairment
in
diseases
such
as
type
1
diabetes;
however,
how
capillary
flow
affected
and
the
underlying
mechanisms
remain
elusive.
Here
we
show
that
capillaries
diabetic
mouse
brain
both
sexes
are
prone
to
stalling,
blocks
consisting
primarily
of
erythrocytes
branches
off
ascending
venules.
Screening
for
circulating
inflammatory
cytokines
revealed
persistently
high
levels
interleukin-10
(IL-10)
mice.
Contrary
expectation,
stimulating
IL-10
signalling
increased
obstruction,
whereas
inhibiting
receptors
neutralizing
antibodies
or
endothelial
specific
knockdown
mice
reversed
these
impairments.
Chronic
treatment
receptor
improved
cerebral
blood
flow,
flux
diameter,
downregulated
haemostasis
cell
adhesion-related
gene
expression,
deficits.
These
data
suggest
has
an
unexpected
pathogenic
role
microcirculatory
defects
diabetes.
Interleukin-10
promotes
formation
a
model
Cell Metabolism,
Journal Year:
2022,
Volume and Issue:
34(11), P. 1620 - 1653
Published: Nov. 1, 2022
The
analogy
of
mitochondria
as
powerhouses
has
expired.
Mitochondria
are
living,
dynamic,
maternally
inherited,
energy-transforming,
biosynthetic,
and
signaling
organelles
that
actively
transduce
biological
information.
We
argue
the
processor
cell,
together
with
nucleus
other
they
constitute
mitochondrial
information
processing
system
(MIPS).
In
a
three-step
process,
(1)
sense
respond
to
both
endogenous
environmental
inputs
through
morphological
functional
remodeling;
(2)
integrate
network-based
physical
interactions
diffusion
mechanisms;
(3)
produce
output
signals
tune
functions
systemically
regulate
physiology.
This
input-to-output
transformation
allows
metabolic,
biochemical,
neuroendocrine,
local
or
systemic
enhance
organismal
adaptation.
An
explicit
focus
on
signal
transduction
emphasizes
role
communication
in
biology.
framework
also
opens
new
avenues
understand
how
mediate
inter-organ
processes
underlying
human
health.
Annual Review of Physiology,
Journal Year:
2021,
Volume and Issue:
84(1), P. 331 - 354
Published: Oct. 21, 2021
The
vast
majority
of
the
brain's
vascular
length
is
composed
capillaries,
where
our
understanding
blood
flow
control
remains
incomplete.
This
review
synthesizes
current
knowledge
on
across
microvascular
zones
by
addressing
issues
with
nomenclature
and
drawing
new
developments
from
in
vivo
optical
imaging
single-cell
transcriptomics.
Recent
studies
have
highlighted
important
distinctions
mural
cell
morphology,
gene
expression,
contractile
dynamics,
which
can
explain
observed
differences
response
to
vasoactive
mediators
between
arteriole,
transitional,
capillary
zones.
Smooth
muscle
cells
arterioles
ensheathing
pericytes
arteriole-capillary
transitional
zone
large-scale,
rapid
changes
flow.
In
contrast,
downstream
act
slower
smaller
scales
are
involved
establishing
resting
tone
heterogeneity.
Many
unresolved
remain,
including
that
activate
different
pericyte
types
vivo,
role
pericyte-endothelial
communication
conducting
signals
capillaries
arterioles,
how
neurological
disease
affects
these
mechanisms.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
39(1), P. 110599 - 110599
Published: April 1, 2022
Astrocytes
establish
extensive
networks
via
gap
junctions
that
allow
each
astrocyte
to
connect
indirectly
the
vasculature.
However,
proportion
of
astrocytes
directly
associated
with
blood
vessels
is
unknown.
Here,
we
quantify
structural
contacts
cortical
vasculature
in
vivo.
We
show
all
are
connected
at
least
one
vessel.
Moreover,
contact
more
deeper
layers
where
vessel
density
known
be
higher.
Further
examination
different
brain
regions
reveals
only
hippocampus,
which
has
lowest
investigated
regions,
harbors
single
no
apparent
vascular
connection.
In
summary,
almost
gray
matter
have
direct
addition
glial
network,
a
access
may
represent
complementary
pathway
for
metabolite
uptake
and
distribution.
Stroke,
Journal Year:
2023,
Volume and Issue:
54(3), P. 673 - 685
Published: Feb. 27, 2023
The
incidence
of
age-related
dementia
is
increasing
as
the
world
population
ages
and
due
to
lack
effective
treatments
for
dementia.
Vascular
contributions
cognitive
impairment
are
prevalence
pathologies
associated
with
cerebrovascular
disease
rise,
including
chronic
hypertension,
diabetes,
ischemic
stroke.
hippocampus
a
bilateral
deep
brain
structure
that
central
learning,
memory,
function
highly
susceptible
hypoxic/ischemic
injury.
Compared
cortical
regions
such
somatosensory
cortex,
less
known
about
hippocampal
vasculature
critical
in
maintaining
neurocognitive
health.
This
review
focuses
on
vascular
supply,
presenting
what
hemodynamics
blood-brain
barrier
during
health
disease,
discusses
evidence
supports
its
contribution
Understanding
vascular-mediated
injury
contributes
memory
dysfunction
healthy
aging
essential
develop
slow
decline.
may
represent
one
therapeutic
target
mitigate
epidemic.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 30, 2024
Abstract
Aging
is
frequently
associated
with
compromised
cerebrovasculature
and
pericytes.
However,
we
do
not
know
how
normal
aging
differentially
impacts
vascular
structure
function
in
different
brain
areas.
Here
utilize
mesoscale
microscopy
methods
vivo
imaging
to
determine
detailed
changes
aged
murine
cerebrovascular
networks.
Whole-brain
tracing
shows
an
overall
~10%
decrease
length
branching
density
~7%
increase
radii
brains.
Light
sheet
3D
immunolabeling
reveals
increased
arteriole
tortuosity
of
Notably,
vasculature
pericyte
densities
show
selective
significant
reductions
the
deep
cortical
layers,
hippocampal
network,
basal
forebrain
We
find
blood
extravasation,
implying
blood-brain
barrier
Moreover,
awake
mice
demonstrates
reduced
baseline
on-demand
oxygenation
despite
relatively
intact
neurovascular
coupling.
Collectively,
uncover
regional
vulnerabilities
network
physiological
that
can
mediate
cognitive
decline
aging.
Neuropsychopharmacology,
Journal Year:
2021,
Volume and Issue:
47(1), P. 20 - 40
Published: Sept. 28, 2021
Abstract
The
fundamental
importance
of
prefrontal
cortical
connectivity
to
information
processing
and,
therefore,
disorders
cognition,
emotion,
and
behavior
has
been
recognized
for
decades.
Anatomic
tracing
studies
in
animals
have
formed
the
basis
delineating
direct
monosynaptic
connectivity,
from
cells
origin,
through
axon
trajectories,
synaptic
terminals.
Advances
neuroimaging
combined
with
network
science
taken
lead
developing
complex
wiring
diagrams
or
connectomes
human
brain.
A
key
question
is
how
well
these
magnetic
resonance
imaging
(MRI)-derived
networks
hubs
reflect
anatomic
“hard
wiring”
first
proposed
underlie
distribution
large-scale
interactions.
In
this
review,
we
address
challenge
by
focusing
on
what
known
about
connections
non-human
primates
compares
MRI-derived
measurements
organization
humans.
First,
outline
pathways
each
cortex
(PFC)
region.
We
then
review
available
MRI-based
techniques
indirectly
measuring
structural
functional
introduce
graph
theoretical
methods
analysis
hubs,
modules,
topologically
integrative
features
connectome.
Finally,
bring
two
approaches
together,
using
specific
examples,
demonstrate
connections,
demonstrated
tract-tracing
studies,
can
directly
inform
understanding
composition
PFC
nodes
edges
that
connect
subcortical
areas.
Cell Reports Methods,
Journal Year:
2022,
Volume and Issue:
2(4), P. 100189 - 100189
Published: March 23, 2022
Vascular
networks
are
fundamental
components
of
biological
systems.
Quantitative
analysis
and
observation
the
features
these
can
improve
our
understanding
their
roles
in
health
disease.
Recent
advancements
imaging
technologies
have
enabled
generation
large-scale
vasculature
datasets,
but
barriers
to
analyzing
datasets
remain.
Modern
options
mainly
limited
paid
applications
or
open-source
terminal-based
software
that
requires
programming
knowledge
with
high
learning
curves.
Here,
we
describe
VesselVio,
an
application
developed
analyze
visualize
pre-binarized
pre-constructed
vascular
graphs.
Vasculature
graphs
be
loaded
annotations
processed
custom
parameters.
program
is
tested
on
ground-truth
compared
current
pipelines.
The
utility
VesselVio
demonstrated
by
multiple
formats
2D
3D
acquired
several
modalities,
including
annotated
mouse
whole-brain
volumes.
