Non-homogenous axonal bouton distribution in whole-brain single-cell neuronal networks DOI Creative Commons

Penghao Qian,

Linus Manubens-Gil, Shengdian Jiang

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(3), P. 113871 - 113871

Published: March 1, 2024

We examined the distribution of pre-synaptic contacts in axons mouse neurons and constructed whole-brain single-cell neuronal networks using an extensive dataset 1,891 fully reconstructed neurons. found that bouton locations were not homogeneous throughout axon among brain regions. As our algorithm was able to generate connectivity matrices from full morphology reconstruction datasets, we further non-homogeneous have a significant impact on network wiring, including degree distribution, triad census, community structure. By perturbing morphology, explored link between anatomical details topology. In silico exploration, dendritic axonal tree span would greatest followed by synaptic contact deletion. Our results suggest neuroanatomical must be carefully addressed studies at level.

Language: Английский

A cortico-subcortical loop for motor control via the pontine reticular formation DOI
Emília Bősz, Viktor Plattner, László Bíró

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115230 - 115230

Published: Jan. 22, 2025

Language: Английский

Citations

1
A cortico-basal ganglia-thalamo-cortical channel underlying short-term memory DOI Creative Commons
Yu Wang, Xinxin Yin, Zhouzhou Zhang

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(21), P. 3486 - 3499.e7

Published: Aug. 31, 2021

Language: Английский

Citations

48
Striatonigrostriatal circuit architecture for disinhibition of dopamine signaling DOI Creative Commons

Priscilla Ambrosi,

Talia N. Lerner

Cell Reports, Journal Year: 2022, Volume and Issue: 40(7), P. 111228 - 111228

Published: Aug. 1, 2022

The basal ganglia operate largely in closed parallel loops, including an associative circuit for goal-directed behavior originating from the dorsomedial striatum (DMS) and a somatosensory important habit formation dorsolateral (DLS). An exception to this organization has been proposed explain how information might be transferred between striatal subregions, example, DMS DLS during formation. "ascending spiral hypothesis" proposes that disinhibits dopamine signaling through tri-synaptic, open-loop striatonigrostriatal circuit. Here, we use transsynaptic intersectional genetic tools investigate both closed- circuits. We find strong evidence which would allow subregions regulate their own release. also functional synapses open loops. However, these are unable modulate tonic neuron firing, questioning prominence of role mediating crosstalk subregions.

Language: Английский

Citations

36
Functional Organisation of the Mouse Superior Colliculus DOI Creative Commons
Thomas Wheatcroft, Aman B. Saleem, Samuel G. Solomon

et al.

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 16

Published: April 29, 2022

The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that widely implicated in organisation and control behaviour. SC receives input from large number brain areas, provides outputs to areas. convergence divergence anatomical connections with different areas systems challenges for understanding how contributes Recent work mouse has provided datasets, wealth new data experiments identify manipulate cells within SC, their inputs outputs, during simple behaviours. These offer an opportunity better understand roles plays these However, some observations appear, at first sight, be contradictory. Here we review this recent hypothesise framework which can capture observations, requires only small change previous models. Specifically, functional explained by supposing three largely distinct circuits support classes behaviours–arrest, turning towards, triggering escape or capture. behaviours are hypothesised supported optic, intermediate deep layers, respectively.

Language: Английский

Citations

32
The caudal prethalamus: Inhibitory switchboard for behavioral control? DOI Creative Commons
Alex Fratzl, Sonja B. Hofer

Neuron, Journal Year: 2022, Volume and Issue: 110(17), P. 2728 - 2742

Published: Sept. 1, 2022

Language: Английский

Citations

29
Coupling between motor cortex and striatum increases during sleep over long-term skill learning DOI Creative Commons
Stefan Lemke, Dhakshin Ramanathan,

David Darevksy

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Sept. 10, 2021

The strength of cortical connectivity to the striatum influences balance between behavioral variability and stability. Learning consistently produce a skilled action requires plasticity in corticostriatal associated with repeated training action. However, it remains unknown whether such occurs during itself or 'offline' time away from training, as sleep. Here, we monitor network throughout long-term skill learning rats find that non-rapid-eye-movement (NREM) sleep is relevant period for plasticity. We first show offline activation striatal NMDA receptors required learning. then functional increases offline, coupled emerging consistent movements, cross-area neural dynamics. identify NREM spindles uniquely poised mediate plasticity, through interactions slow oscillations. Our results provide evidence shapes coupling

Language: Английский

Citations

35
The Mesencephalic Locomotor Region: Beyond Locomotor Control DOI Creative Commons
Brian R. Noga, Patrick J. Whelan

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 16

Published: May 9, 2022

The mesencephalic locomotor region (MLR) was discovered several decades ago in the cat. It functionally defined based on ability of low threshold electrical stimuli within a comprising cuneiform and pedunculopontine nucleus to evoke locomotion. Since then, similar regions have been found diverse vertebrate species, including lamprey, skate, rodent, pig, monkey, human. MLR, while often viewed under lens locomotion, is involved processes involving autonomic nervous system, respiratory state-dependent activation motor systems. This review will discuss that comprises MLR examine their respective connectomes from both an anatomical functional angle. From perspective, primes cardiovascular systems before activity occurs. Inputs variety higher structures, direct outputs monoaminergic nuclei, allow be able respond appropriately These effects are roughly divided into escape exploratory behavior, also can reinforce selection these behaviors through projections adjacent structures such as periaqueductal gray or limbic cortical regions. Findings rat, mouse, cat discussed highlight similarities differences among species.

Language: Английский

Citations

28
Dynamical mechanism of parkinsonian beta oscillation in a heterogenous subthalamopallidal network DOI
Xiaomin Wang, Ying Yu, Fang Han

et al.

Nonlinear Dynamics, Journal Year: 2023, Volume and Issue: 111(11), P. 10505 - 10527

Published: April 11, 2023

Language: Английский

Citations

15
Targeting parvalbumin-expressing neurons in the substantia nigra pars reticulata restores motor function in parkinsonian mice DOI Creative Commons
Lorena Delgado-Zabalza, Nicolas Mallet, Christelle Glangetas

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(10), P. 113287 - 113287

Published: Oct. 1, 2023

The activity of substantia nigra pars reticulata (SNr) neurons, the main output structure basal ganglia, is altered in Parkinson's disease (PD). However, neither underlying mechanisms nor type neurons responsible for PD-related motor dysfunctions have been elucidated yet. Here, we show that parvalbumin-expressing SNr (SNr-PV+) occupy dorsolateral parts and possess specific electrophysiological properties compared with other cells. We also report only SNr-PV+ neurons' intrinsic excitability reduced by downregulation sodium leak channels a PD mouse model. Interestingly, anesthetized parkinsonian mice vivo, display bursty pattern dependent on glutamatergic tone. Finally, demonstrate chemogenetic inhibition sufficient to alleviate impairments mice. Overall, our findings establish cell-type-specific dysfunction experimental parkinsonism provide potential cellular therapeutic target symptoms PD.

Language: Английский

Citations

15
Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease DOI Creative Commons
Shenyu Zhai, Qiaoling Cui, DeNard V. Simmons

et al.

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 83, P. 102798 - 102798

Published: Oct. 30, 2023

The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia is responsible for cardinal motor symptoms Parkinson's disease (PD). It has been thought loss signaling in one region - striatum was solely network pathophysiology causing PD symptoms. While our understanding dopamine (DA)'s role modulating striatal circuitry deepened recent years, it also become clear acts other regions to influence movement. Underscoring this point, examination a new progressive mouse model shows DA depletion alone not sufficient induce parkinsonism and restoration extra-striatal attenuates parkinsonian deficits once they appear. This review summarizes advances effort understand circuitry, its modulation by DA, how dysfunction drives

Language: Английский

Citations

15