Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex DOI Creative Commons
Alyse M. Thomas, Weiguo Yang, Catherine Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 24, 2023

Action selection occurs through competition between potential choice options. Neural correlates of are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate remains unresolved. Here we report that cell types within SC can bidirectionally modulate drive activity in cortex. In the mouse, topographically matched formed a descending motor pathway for directional licking re-entrant loop via thalamus. During distinct neuronal populations both encoded opposing lick directions exhibited push-pull dynamics. GABAergic neurons ipsilateral glutamatergic contralateral choice, activating or suppressing could These results thus identify as major locus broader action network.

Language: Английский

Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns DOI

Humingzhu Li,

Tao Jiang, Sile An

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(7), P. 1081 - 1099.e7

Published: Jan. 29, 2024

Language: Английский

Citations

18
Mapping visual functions onto molecular cell types in the mouse superior colliculus DOI Creative Commons
Yuanming Liu, Élise Savier,

Victor J. DePiero

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(12), P. 1876 - 1886.e5

Published: April 21, 2023

The superficial superior colliculus (sSC) carries out diverse roles in visual processing and behaviors, but how these functions are delegated among collicular neurons remains unclear. Here, using single-cell transcriptomics, we identified 28 neuron subtypes subtype-enriched marker genes from tens of thousands adult mouse sSC neurons. We then asked whether the sSC's molecular tuned to different stimuli. Specifically, imaged calcium dynamics single vivo during stimulation mapped gene transcripts onto same ex vivo. Our results identify a subtype inhibitory accounting for ∼50% direction-selective cells, suggesting genetic logic functional organization sSC. In addition, our studies provide comprehensive atlas multimodal mapping method that will facilitate investigation their respective functions, connectivity, development.

Language: Английский

Citations

36
Kinetic features dictate sensorimotor alignment in the superior colliculus DOI Creative Commons
Ana González-Rueda, Kristopher T. Jensen, Mohammadreza Noormandipour

et al.

Nature, Journal Year: 2024, Volume and Issue: 631(8020), P. 378 - 385

Published: July 3, 2024

Abstract The execution of goal-oriented behaviours requires a spatially coherent alignment between sensory and motor maps. current model for sensorimotor transformation in the superior colliculus relies on topographic mapping static spatial receptive fields onto movement endpoints 1–6 . Here, to experimentally assess validity this canonical alignment, we dissected visuo-motor network performed vivo intracellular extracellular recordings across layers, restrained unrestrained conditions, both visual tuning individual premotor neurons. We found that collicular units have poorly defined respond instead kinetic features, revealing existence direct vectorial space vectors, rather than as canonically hypothesized. show neural built according these principles is ideally placed sustain ethological such rapid interception moving targets. These findings reveal novel dimension process. By extending from domain work provides conceptual framework understanding nature convergence its relevance guiding goal-directed behaviours.

Language: Английский

Citations

11
Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines DOI Creative Commons
Chen Chen, Yuanming Liu, Jianhua Cang

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112194 - 112194

Published: March 11, 2025

Recent studies have revealed diverse neuron types in the superior colliculus (SC), a midbrain structure critical for sensorimotor transformation. Here, as an important step toward studying function of these subtypes, we characterize 10 transgenic mouse lines based on recently published molecular atlas superficial SC. We show that Cre or fluorescence expression some corresponds specifically to certain transcriptomic types. These include two GENSAT been used target morphological cell SC and three knockin lines. In contrast, such correspondence is not seen other tested mice. Importantly, pattern marker genes all highly consistent with atlas. Together, our support correlation between types, identify useful targeting genetically, demonstrate validity single-cell transcriptomics data.

Language: Английский

Citations

1
Functional cell types in the mouse superior colliculus DOI Creative Commons
Ya-tang Li, Markus Meister

eLife, Journal Year: 2023, Volume and Issue: 12

Published: April 19, 2023

The superior colliculus (SC) represents a major visual processing station in the mammalian brain that receives input from many types of retinal ganglion cells (RGCs). How parallel channels exist SC, and what information does each encode? Here, we recorded mouse superficial SC neurons under battery stimuli including those used for classification RGCs. An unsupervised clustering algorithm identified 24 functional based on their responses. They fall into two groups: one responds similarly to RGCs another with more diverse specialized stimulus selectivity. second group is dominant at greater depths, consistent vertical progression signal SC. Cells same type tend cluster near other anatomical space. Compared retina, representation has lower dimensionality, sifting process along pathway.

Language: Английский

Citations

21
Retinal origin of orientation but not direction selective maps in the superior colliculus DOI Creative Commons
Daniel de Malmazet, Norma K. Kühn, Chen Li

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(6), P. 1222 - 1233.e7

Published: Feb. 27, 2024

Language: Английский

Citations

6
Genetically defined neuron types underlying visuomotor transformation in the superior colliculus DOI
Jianhua Cang, Chen Chen,

Chuiwen Li

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

Citations

6
Superior colliculus bidirectionally modulates choice activity in frontal cortex DOI Creative Commons
Alyse M. Thomas, Weiguo Yang, Catherine Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 14, 2023

Abstract Action selection occurs through competition between potential choice options. Neural correlates of are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate remains unresolved. Here we report that SC can bidirectionally modulate drive activity in cortex. In the mouse, topographically matched formed a descending motor pathway for directional licking re-entrant loop via thalamus. During distinct neuronal populations both encoded opposing lick directions exhibited competitive interactions. GABAergic neurons ipsilateral locally inhibited glutamatergic contralateral choice. Activating or suppressing cell types could These results thus identify as major locus within broader action network.

Language: Английский

Citations

13
Neural Circuit Mechanisms Involved in Animals’ Detection of and Response to Visual Threats DOI
Qiwen Wu, Yifeng Zhang

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 39(6), P. 994 - 1008

Published: Jan. 25, 2023

Language: Английский

Citations

11
Neurocircuitry of Predatory Hunting DOI Creative Commons
Zhengdong Zhao, Li Zhang, Xinkuan Xiang

et al.

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 39(5), P. 817 - 831

Published: Jan. 27, 2023

Abstract Predatory hunting is an important type of innate behavior evolutionarily conserved across the animal kingdom. It typically composed a set sequential actions, including prey search, pursuit, attack, and consumption. This subject to control by nervous system. Early studies used toads as model probe neuroethology hunting, which led proposal sensory-triggered release mechanism for actions. More recent have genetically-trackable zebrafish rodents made breakthrough discoveries in neurocircuits underlying this behavior. Here, we review sophisticated neurocircuitry involved summarize detailed circuitry encode various aspects neuroethology, sensory processing, sensorimotor transformation, motivation, encoding We also discuss overlapping brain circuits feeding point out limitations current studies. propose that ideal behavioral paradigm study motivated behaviors, may shed new light on epidemic disorders, binge-eating, obesity, obsessive-compulsive disorders.

Language: Английский

Citations

11